1. Anti-infection
  2. SARS-CoV
  3. SARS-CoV-IN-4

SARS-CoV-IN-4 

Cat. No.: HY-143467
Handling Instructions

SARS-CoV-IN-4 (compound 13) is a potent and specific inhibitor of SARS-CoV nsp14 N7-methyltransferase, with an IC50 of 0.6 μM (SARS-CoV nsp14).

For research use only. We do not sell to patients.

SARS-CoV-IN-4 Chemical Structure

SARS-CoV-IN-4 Chemical Structure

CAS No. : 2445585-37-3

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Description

SARS-CoV-IN-4 (compound 13) is a potent and specific inhibitor of SARS-CoV nsp14 N7-methyltransferase, with an IC50 of 0.6 μM (SARS-CoV nsp14)[1].

IC50 & Target

IC50: 0.6 ± 0.1 μM (SARS-CoV nsp14), 247.5 ± 14.9 μM (hRNMT)[1]

In Vitro

SARS-CoV-IN-4 (compound 13) shows inhibitory activity on N7-MTases, with inhibition at 50 μM of 97.2 ± 2.7% (SARS-CoV nsp14), and 33.9 ± 3.3% (hRNMT), respectively[1].
SARS-CoV-IN-4 stabilizes SARS-CoV nsp14 against thermal denaturation with a ΔTm +10.8 °C and exhibits notable binding affinity (apparent KD 1.3 ± 0.87 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

779.14

Formula

C28H31ClN12O11S

CAS No.
SMILES

O[[email protected]]([[email protected]@H]1O)[[email protected]@](N2C3=NC=NC(N)=C3N=C2)([H])O[[email protected]@H]1CN(S(=O)(C4=CC([N+]([O-])=O)=C(C=C4)Cl)=O)CCO[[email protected]]5[[email protected]](O[[email protected]@H]([[email protected]]5O)CO)([H])N6C7=NC=NC(N)=C7N=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Cat. No.:
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