SARS-CoV-IN-4
SARS-CoV-IN-4 (compound 13) is a potent and specific inhibitor of SARS-CoV nsp14 N7-methyltransferase, with an IC50 of 0.6 μM (SARS-CoV nsp14).
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- No. CAS: 2445585-37-3
- Fòrmula: C28H31ClN12O11S
- Peso molecular:779.14
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
IC50: 0.6 ± 0.1 μM (SARS-CoV nsp14), 247.5 ± 14.9 μM (hRNMT)[1]
SARS-CoV-IN-4 (compound 13) shows inhibitory activity on N7-MTases, with inhibition at 50 μM of 97.2 ± 2.7% (SARS-CoV nsp14), and 33.9 ± 3.3% (hRNMT), respectively[1].
SARS-CoV-IN-4 stabilizes SARS-CoV nsp14 against thermal denaturation with a ΔTm +10.8 °C and exhibits notable binding affinity (apparent KD 1.3 ± 0.87 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2445585-37-3
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Peso molecular 779.14
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Fòrmula C28H31ClN12O11S
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SMILES
O[C@H]([C@@H]1O)[C@@](N2C3=NC=NC(N)=C3N=C2)([H])O[C@@H]1CN(S(=O)(C4=CC([N+]([O-])=O)=C(C=C4)Cl)=O)CCO[C@H]5[C@](O[C@@H]([C@H]5O)CO)([H])N6C7=NC=NC(N)=C7N=C6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-IN-4 Related Classifications
HY-143467 Related Classifications
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