2925324-58-7
Chemical Structure
MAT2A-IN-23
- CAS No.: 2925324-58-7
- Formula:C19H14D3F2N3O
- Molecular Weight:344.37
InChIKey: PFTZYFOUUADGIB-KQRZERNSSA-N
SMILES: O=C1[C@]2(C3=CC(C(F)(C)F)=CC=C3C(NC([2H])([2H])[2H])=N1)C4=CC=CN=C4CC2
Biological Activity: MAT2A-IN-23 (compound 39) is a MAT2A inhibitor, with an IC50 of 4 nM. MAT2A-IN-23 inhibits SAM in the HCT-116 (MTAP−/−) and in the HCT-116 WT cell line with IC50s of 3 and 2 nM, respectively. MAT2A-IN-23 inhibits SDMA in the HCT-116 (MTAP−/−) and in the HCT-116 WT cell line with IC50s of 2 and >3000 nM, respectively. MAT2A-IN-23 inhibits HCT-116 (MTAP−/−) cell proliferation with with an IC50 of 47 nM[1].
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MAT2A-IN-23 | MAT2A-IN-23 (compound 39) is a MAT2A inhibitor, with an IC50 of 4 nM. MAT2A-IN-23 inhibits SAM in the HCT-116 (MTAP−/−) and in the HCT-116 WT cell line with IC50s of 3 and 2 nM, respectively. MAT2A-IN-23 inhibits SDMA in the HCT-116 (MTAP−/−) and in the HCT-116 WT cell line with IC50s of 2 and >3000 nM, respectively. MAT2A-IN-23 inhibits HCT-116 (MTAP−/−) cell proliferation with with an IC50 of 47 nM. | |||||||||||||||||||||
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Keywords
