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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
α2δ-1
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "α2δ-1" in MCE Product Catalog:
6
6 Publications Verification
Synonyms: DS5565
Target:
Research Areas:
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
6
6 Publications Verification
Synonyms: DS 5565 besylate
Target:
Research Areas:
Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.
Cat. No.: HY-12650S1
Synonyms: DS5565-d4
Cat. No.: HY-148866
CAS No.: 2143584-82-9
Target:
Research Areas:
Cavα2δ1&NET-IN-3 (example 216) is an inhibitor of the subunit α2δ of voltage-gated calcium channels (VGCC) and noradrenaline transporter (NET). Cavα2δ1&NET-IN-3 has Kis of 100-500 nM for human α2δ-1 subunit of Cav2.2 calcium channel and NET, respectively .
Cat. No.: HY-P3431
CAS No.: 2279952-25-7
Target:
Research Areas:
Cat. No.: HY-148863
CAS No.: 2143586-17-6
Target:
Research Areas:
Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain .
Cat. No.: HY-12650S
Synonyms: DS5565-13C2,d1 (Mixture of Diastereomers)
Cat. No.: HY-P3431A
Target:
Research Areas:
Cat. No.: HY-148862
CAS No.: 2314361-39-0
Target:
Research Areas:
Cavα2δ1&NET-IN-1 (Compound 59S) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-1 inhibits Cavα2δ-1 with a Ki of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a Ki of 383 nM and IC50 of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain .
Cat. No.: HY-12650R
CAS No.: 1138245-13-2
Synonyms: DS5565 (Standard)
Target:
Research Areas:
Mirogabalin (Standard) is the analytical standard of Mirogabalin. This product is intended for research and analytical applications. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
Cat. No.: HY-12650A
CAS No.: 1138244-97-9
Synonyms: (rel)-DS5565
Target:
Research Areas:
(rel)-Mirogabalin ((rel)-DS5565) is a voltage-dependent calcium channel inhibitor that acts on the α2δ-1 subunit .
Cat. No.: HY-U00388
CAS No.: 313653-15-5
Target:
Research Areas:
α2δ ligand 1 is a ligand to the α2δ-1 subunit of voltage-sensitive calcium channel, extracted from patent US20040186177.
Cat. No.: HY-132932
CAS No.: 2416957-09-8
Target:
Research Areas:
Cavα2δ-IN-1 shows high selectivity for voltage-gated calcium channels Cavα2δ-1 (Ki 6 nM) versus Cavα2δ-2 (Ki ＞ 10000 nM).
Cat. No.: HY-108006R
CAS No.: 1138245-21-2
Synonyms: DS 5565 besylate (Standard)
Target:
Research Areas:
Mirogabalin besylate (Standard) is the analytical standard of Mirogabalin besylate (HY-108006). This product is intended for research and analytical applications. Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.
Cat. No.: HY-P72109
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CACNA2D1; Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1; Prev. CACNL2A; CCHL2A; Prev. LINC01112; Dihydropyridine-Sensitive L-Type, Calcium Channel Alpha-2/Delta Subunit; Prev. CACNA2; Calcium Channel, L Type, Alpha 2 Polypeptide; Prev. MHS3; L
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
