Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
15-PGDH
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "15-PGDH" in MCE Product Catalog:
8
8 Cited Publications
Cat. No.: HY-16968
CAS No.: 459147-39-8
SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration .
Cat. No.: HY-174990
CAS No.: 2927452-83-1
Target:
Research Areas:
HW201877 is a potent and orally active 15-prostaglandin dehydrogenase (15-PGDH) inhibitor with an IC50 of 3.6 nM. HW201877 demonstrates robust cellular efficacy in elevating PGE2 levels in A549 cells and exhibits remarkable efficacy in animal models of tissue injury and fibrosis. HW201877 can be used for the study of inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF) and Crohn’s disease (CD) .
Cat. No.: HY-176803
CAS No.: 2673403-86-4
Target:
Research Areas:
MF-DH-300 is a 15-PGDH inhibitor that can be applicable to the research of muscle disorders such as spinal muscular atrophy (SMA).
Target:
Research Areas:
15-PGDH-IN-1 is a potent and orally active 15-PGDH inhibitior. 15-PGDH-IN-1 has inhibition activity against recombinant human 15-PGDH with an IC50 value of 3 nM. 15-PGDH-IN-1 can be used for the research of tissue repair and regeneration .
Target:
Research Areas:
ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways .
Cat. No.: HY-117723
CAS No.: 452077-89-3
MF-PGDH-008 serves as an inhibitor of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) .
Cat. No.: HY-178113
CAS No.: 1537192-10-1
Target:
Research Areas:
15-PGDH-IN-4 (Compound 40) is a 15-PGDH inhibitor with an IC50 of 1.2 nM against h15-PGDH. 15-PGDH-IN-4 functionally inhibits the activity of 15-PGDH. 15-PGDH-IN-4 can be used in the research of colitis .
Cat. No.: HY-124230
CAS No.: 355827-05-3
Target:
Research Areas:
15-PGDH-IN-3 (Compound 61) is a selective competitive inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) .
Cat. No.: HY-119973
CAS No.: 78028-01-0
Target:
Research Areas:
CAY10397 is a selective and orally active 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor. CAY10397 can inhibit 15-PGDH-dependent endogenous metabolite production. CAY10397 blocks the selenium-dependent protective in inflammation. CAY10397 can be used for the research of colitis .
Cat. No.: HY-116198
CAS No.: 1221413-57-5
Target:
Research Areas:
15-PGDH-IN-2 (Compound 2) is a 15-PGDH inhibitor with an IC50 value of 0.274 nM. 15-PGDH-IN-2 can be used in research on hair loss, bone formation, gastric ulcer healing, and dermal wound healing .
Cat. No.: HY-P10457
Synonyms: 15-PGDH (92-105)
Cat. No.: HY-116096
CAS No.: 20897-91-0
Synonyms: 15(R)-Prostaglandin E1; 15-Epiprostaglandin E1
15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1) is a stereoisomer of PGE1 (HY-B0131) but with less biological activity . 15-epi-PGE1 is a non-competitive inhibitor for human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) with an IC50 of 170 μM .
Cat. No.: HY-16968A
CAS No.: 1714961-54-2
(R)-SW033291 is the R-type enantiomer of SW033291 (HY-16968). (R)-SW033291 is a potent and high-affinity inhibitor of 15-PGDH. (R)-SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. (R)-SW033291 also promotes tissue regeneration .
Cat. No.: HY-183651
CAS No.: 1714984-32-3
Target:
Research Areas:
15-PGDH-IN-5 is a sulfoxide-based inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH-IN-5 exhibits great water solubility, metabolic stability, and in vivo exposure levels. 15-PGDH-IN-5 blocks the 15-PGDH-mediated irreversible oxidative degradation of PGE2 and increases the effective concentration of endogenous PGE2 in tissues, thereby exerting anti-inflammatory effects and promoting tissue repair and regeneration. 15-PGDH-IN-5 is suitable for research into tissue injury and fibrosis-related diseases, such as inflammatory bowel disease and idiopathic pulmonary fibrosis .
Cat. No.: HY-P81351A
Synonyms: 15-PGDH; Hpgd; PGDH; PGDH1; PHOAR1; SDR36C1
Cat. No.: HY-P75555
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HPGD; Hydroxyprostaglandin Dehydrogenase 15-(NAD); 15-Hydroxyprostaglandin Dehydrogenase; 15-PGDH; SDR36C1; PGDH1; 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)]; Short Chain Dehydrogenase/Reductase Family 36C, Member 1; Prostaglandin Dehydrogenase 1; NAD
Species:
Mouse
Source:
E. coli
Cat. No.: HY-174990A
CAS No.: 2927452-82-0
Target:
Research Areas:
HW201877 enantiomer is the enantiomer of HW201877 (HY-174990) and is 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor with an IC50 of 12.2 nM. HW201877 enantiomer can be used for the research of inflammatory bowel disease, idiopathic pulmonary fibrosis, ulcerative colitis, and Crohn's disease .
Cat. No.: HY-RS06339
Target:
Research Areas:
Hpgd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hpgd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06338
Target:
Research Areas:
HPGD Human Pre-designed siRNA Set A contains three designed siRNAs for HPGD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
