2. Metabolic Enzyme/Protease
  3. 15-PGDH
  4. 15-PGDH-IN-5

15-PGDH-IN-5 (compound 5) is a sulfoxide-derived 15-PGDH inhibitor. 15-PGDH-IN-5 exhibits higher metabolic stability and superior in vivo exposure compared with the lead compound SW033291 (HY-16968). 15-PGDH-IN-5 inhibits the irreversible oxidative catabolism of PGE2 by 15-PGDH, thereby enhancing the tissue-specific bioavailability of endogenous PGE2. 15-PGDH-IN-5 exerts anti-inflammatory effects and accelerates tissue repair and regeneration, and it is used in studies on tissue injury and fibrosis-related diseases such as inflammatory bowel disease and idiopathic pulmonary fibrosis.

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15-PGDH-IN-5

15-PGDH-IN-5 Chemical Structure

CAS No. : 1714984-32-3

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Description

15-PGDH-IN-5 (compound 5) is a sulfoxide-derived 15-PGDH inhibitor. 15-PGDH-IN-5 exhibits higher metabolic stability and superior in vivo exposure compared with the lead compound SW033291 (HY-16968). 15-PGDH-IN-5 inhibits the irreversible oxidative catabolism of PGE2 by 15-PGDH, thereby enhancing the tissue-specific bioavailability of endogenous PGE2. 15-PGDH-IN-5 exerts anti-inflammatory effects and accelerates tissue repair and regeneration, and it is used in studies on tissue injury and fibrosis-related diseases such as inflammatory bowel disease and idiopathic pulmonary fibrosis[1].

Molecular Weight

431.60

Formula

C19H21N5OS3
CAS No.
SMILES

NC1=C([S@+]([O-])CCCC)SC2=NC(C3=NC=CS3)=CC(C4=CN=C(C)N4C)=C12
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Purity & Documentation
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15-PGDH-IN-5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15-PGDH-IN-51714984-32-315-PGDH15-Hydroxyprostaglandin dehydrogenase15-hydroxyprostaglandin dehydrogenaseInhibitorinhibitorinhibit

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