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Cat. No.: HY-183651

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15-PGDH-IN-5

15-PGDH-IN-5 is a sulfoxide-based inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH-IN-5 exhibits great water solubility, metabolic stability, and in vivo exposure levels. 15-PGDH-IN-5 blocks the 15-PGDH-mediated irreversible oxidative degradation of PGE2 and increases the effective concentration of endogenous PGE2 in tissues, thereby exerting anti-inflammatory effects and promoting tissue repair and regeneration. 15-PGDH-IN-5 is suitable for research into tissue injury and fibrosis-related diseases, such as inflammatory bowel disease and idiopathic pulmonary fibrosis.

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CAS No.: 1714984-32-3
Formule: C₁₉H₂₁N₅OS₃
Masse moléculaire:431.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

15-PGDH-IN-5 Chemical Structure

CAS No.: 1714984-32-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
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Activité biologique

Description

In Vitro

15-PGDH-IN-5 (compound 5) exhibits enhanced aqueous solubility and improved metabolic stability relative to SW033291^[1].
15-PGDH-IN-5 elevates intracellular prostaglandin E2 (PGE2) levels by blocking the catabolism of PGE2, thereby potentiating tissue repair and regeneration processes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1714984-32-3
Masse moléculaire 431.60
Formule C₁₉H₂₁N₅OS₃
SMILES

NC1=C([S@+]([O-])CCCC)SC2=NC(C3=NC=CS3)=CC(C4=CN=C(C)N4C)=C12
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Li Q, et al. Discovery of : A Highly Potent and Orally Bioavailable Inhibitor of 15-Prostaglandin Dehydrogenase to Potentiate Tissue Repair and Regeneration. Journal of medicinal chemistry. 2025 Jul 10;68(13):14099-14113. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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