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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
100 Results for "
2-Ar-1,2,3-triazole
" in MedChemExpress (MCE) Product Catalog:
Products (100)
100 Results for "2-Ar-1,2,3-triazole" in MCE Product Catalog:
24
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
21
Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
11
Research Areas:
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes. Voriconazole can penetrate the blood brain barrier (BBB) .
5
5 Cited Publications
Synonyms: BAL-4815; RO-0094815
Target:
Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
2
2 Cited Publications
Cat. No.: HY-B0847
CAS No.: 60207-90-1
Research Areas:
Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .
1
Target:
Research Areas:
Opelconazole (PC945), a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. Opelconazole is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively .
Cat. No.: HY-174304
Target:
Research Areas:
Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide is a drug-linker conjugates for ADC. Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide consists of Triptolide (HY-32735) and a stable cleavable linker (Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-Cl) (HY-174810). Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide can be used for the synthesis of antibody-drug conjugates (ADCs) .
Cat. No.: HY-W019852
CAS No.: 76674-21-0
Target:
Research Areas:
Flutriafol is a triazole fungicide with broad spectrum fungicidal activity.
Synonyms: BAL-4815-d4; RO-0094815-d4
Cat. No.: HY-W113615
CAS No.: 1680-44-0
Research Areas:
4-Phenyl-1H-1,2,3-triazole is a selective IDO1 inhibitor with an IC50 of 83 μM against human IDO1. 4-Phenyl-1H-1,2,3-triazole binds to the heme iron of IDO1 and occupies its active site, thereby inhibiting tryptophan catabolism. 4-Phenyl-1H-1,2,3-triazole can serve as a precursor for the synthesis of HIV-1 capsid protein inhibitors. 4-Phenyl-1H-1,2,3-triazole is applicable to research related to cancer and organic synthesis .
Cat. No.: HY-W012991
CAS No.: 3179-31-5
Cat. No.: HY-14273R
CAS No.: 241479-67-4
Synonyms: BAL-4815 (Standard); RO-0094815 (Standard)
Research Areas:
Isavuconazole (Standard) is the analytical standard of Isavuconazole. This product is intended for research and analytical applications. Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
Cat. No.: HY-B0101R
CAS No.: 86386-73-4
Synonyms: UK-49858 (Standard)
Category:
Target:
Cat. No.: HY-17514R
CAS No.: 84625-61-6
Synonyms: R51211 (Standard)
Category:
Cat. No.: HY-B0847R
CAS No.: 60207-90-1
Research Areas:
Propiconazole (Standard) is the analytical standard of Propiconazole. This product is intended for research and analytical applications. Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .
Cat. No.: HY-21058
CAS No.: 23195-62-2
3-(Pyridin-2-yl)-1,2,4-triazole is a metal-organic framework (MOF).
Cat. No.: HY-W007685
CAS No.: 4928-88-5
Cat. No.: HY-B0101A
CAS No.: 155347-36-7
Synonyms: UK 49858 hydrate
Target:
Fluconazole (UK-49858) hydrate is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole hydrate inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
Cat. No.: HY-B0101B
CAS No.: 159532-41-9
Synonyms: UK 49858 mesylate
Target:
Fluconazole (UK-49858) mesylate is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole mesylate inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
