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3-phosphate dehydrogenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldehyde Dehydrogenase (ALDH) (1) Phosphoglycerate Dehydrogenase (PHGDH) (1) Endogenous Metabolite (7) Glucocorticoid Receptor (1) HIF/HIF Prolyl-Hydroxylase (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Metabolic Disease (9) Neurological Disease (1)

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Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended:

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113128A

sn-Glycerol 3-phosphate lithium	Endogenous Metabolite	Metabolic Disease
sn-Glycerol 3-phosphate lithium is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate lithium from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate lithium for lipid metabolism .

HY-113128

sn-Glycerol 3-phosphate	Endogenous Metabolite	Metabolic Disease
sn-Glycerol 3-phosphate is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate for lipid metabolism .

HY-121970

iGP-1	Phosphoglycerate Dehydrogenase (PHGDH) Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
iGP-1 is a cell-permeable, selective mixed inhibitor of mitochondrial sn-glycerol-3-phosphate dehydrogenase (mGPDH), with IC₅₀s of 6.3 μM and 13.6 μM for rat mGPDH activity and H₂O₂ production, respectively. iGP-1 specifically blocks the mitochondrial component of the glycerophosphate shuttle without affecting cytosolic GPDH. iGP-1 not only inhibits cell proliferation and glutaminolysis, and enhances glycolysis, but also significantly alters key cellular physiological processes such as apoptosis, ROS production, HIF-1α stability and mitochondrial membrane potential. iGP-1 remains active in neutrophil cultures under both normoxic and hypoxic conditions, and serves as an ideal probe for glycerol-3-phosphate metabolic mechanisms. iGP-1 has been applied to studies on prostate cancer and related metabolic pathways .

HY-P2765

Glycerol-3-phosphate dehydrogenase, rabbit muscle GPDH; α-Glycerophosphate dehydrogenase; Glycerol phosphate dehydrogenase	Endogenous Metabolite	Metabolic Disease
Glycerol-3-phosphate dehydrogenase, rabbit muscle (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate to sn-glycerol 3-phosphate. Glycerol-3-phosphate dehydrogenase is a glycolytic enzyme and is responsible for the re-oxidation of NADH to NAD ⁺ and energy supply .

HY-113128S

sn-Glycerol 3-phosphate-13C3 disodium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
sn-Glycerol 3-phosphate- ¹³C₃ disodium is the ¹³C-labeled sn-Glycerol 3-phosphate disodium. sn-Glycerol 3-phosphate disodium is produced by cytosolic glycerol 3-phosphate dehydrogenase pathway through the reduction of dihydroxyacetone phosphate using NADH formed during glycolysis .

HY-B1087

Prednisolone hemisuccinate Prednisolone 21-hemisuccinate	Glucocorticoid Receptor	Neurological Disease
Prednisolone hemisuccinate (Prednisolone 21-hemisuccinate) is a prodrug of Prednisolone (HY-17463) and a glucocorticoid. Prednisolone hemisuccinate converts to Prednisolone in vivo. Prednisolone hemisuccinate induces the inactivation of glyceraldehyde-3-phosphate dehydrogenase (GAP-DH) in vitro. Prednisolone hemisuccinate can be used in research related to cataracts .

HY-113128B

sn-Glycerol 3-phosphate biscyclohexylammonium salt	Endogenous Metabolite	Metabolic Disease
sn-Glycerol 3-phosphate biscyclohexylammonium salt is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate biscyclohexylammonium salt from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate biscyclohexylammonium salt for lipid metabolism .

HY-127127

Deamino-NAD	Endogenous Metabolite	Others
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-127127A

Deamino-NAD sodium	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Metabolic Disease
Deamino-NAD sodium is a structural analog of NAD+ (HY-B0445). Deamino-NAD sodium is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-114886

IGP-5	Mitochondrial Metabolism	Metabolic Disease
IGP-5 is a mitochondrial *sn-Glycerol 3-phosphate Dehydrogenase* (mGPDH) inhibitor with the IC₅₀** of 0.7 μM aganist mGPDH H2O2 production . IGP-5 can be used for study of energy metabolism .

Cat. No.	Product Name	Target	Research Area

HY-P4698

Tri-valine NSC 35938	Peptides	Metabolic Disease
Tri-valine (NSC 35938) is a polypeptide that can be separated from Creatine kinase (HY-P2799), β-enolase, Triosephosphate isomerase (HY-P2931) and glyceraldehyde 3-phosphate dehydrogenase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113128A

sn-Glycerol 3-phosphate lithium	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
sn-Glycerol 3-phosphate lithium is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate lithium from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate lithium for lipid metabolism .

HY-113128

sn-Glycerol 3-phosphate	Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
sn-Glycerol 3-phosphate is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate for lipid metabolism .

HY-113128B

sn-Glycerol 3-phosphate biscyclohexylammonium salt	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
sn-Glycerol 3-phosphate biscyclohexylammonium salt is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate biscyclohexylammonium salt from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate biscyclohexylammonium salt for lipid metabolism .

HY-127127

Deamino-NAD	Microorganisms Source Classification	Endogenous Metabolite
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

Cat. No.	Product Name	Chemical Structure

HY-113128S

sn-Glycerol 3-phosphate-13C3 disodium
sn-Glycerol 3-phosphate- ¹³C₃ disodium is the ¹³C-labeled sn-Glycerol 3-phosphate disodium. sn-Glycerol 3-phosphate disodium is produced by cytosolic glycerol 3-phosphate dehydrogenase pathway through the reduction of dihydroxyacetone phosphate using NADH formed during glycolysis .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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