sn-Glycerol 3-phosphate
sn-Glycerol 3-phosphate is an important intermediate in glycolysis and lipid metabolism. The cytosolic sn-Glycerol 3-phosphate dehydrogenase (GPDH) consumes NADH to generate sn-Glycerol 3-phosphate from dihydroxyacetone phosphate (DHAP). Glyceroneogenesis is an important supplier of sn-Glycerol 3-phosphate for lipid metabolism.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 17989-41-2
- Formula: C3H9O6P
- Molecular Weight:172.07
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
The cytosolic GPDH consumes NADH to generate sn-Glycerol 3-phosphate from dihydroxyacetone phosphate (DHAP), and the resulting sn-Glycerol 3-phosphate passes through the permeable mitochondrial outer membrane. sn-Glycerol 3-phosphate is reoxidized to DHAP at the outer surface of the inner mitochondrial membrane by the mitochondrial FAD-GPDH, which donates the electrons to the mitochondrial ubiquinone pool. The DHAP is subsequently channeled back to the cytosolic compartment[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 17989-41-2
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Appearance Solid
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Molecular Weight 172.07
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Formula C3H9O6P
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Color White to off-white
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SMILES
O[C@H](CO)COP(O)(O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 125 mg/mL (726.45 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (145.29 mM); Clear solution; Need ultrasonic and warming
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Frasson D, et al. The sympathetic nervous system regulates the three glycerol-3P generation pathways in white adipose tissue of fasted, diabetic and high-protein diet-fed rats. Metabolism. 2012 Oct;61(10):1473-85. [Content Brief]
[2]. Shen W, et al. Involvement of a glycerol-3-phosphate dehydrogenase in modulating the NADH/NAD+ ratio provides evidence of a mitochondrial glycerol-3-phosphate shuttle in Arabidopsis. Plant Cell. 2006 Feb;18(2):422-41. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.8116 mL | 29.0579 mL | 58.1159 mL | 145.2897 mL |
| 5 mM | 1.1623 mL | 5.8116 mL | 11.6232 mL | 29.0579 mL | |
| 10 mM | 0.5812 mL | 2.9058 mL | 5.8116 mL | 14.5290 mL | |
| 15 mM | 0.3874 mL | 1.9372 mL | 3.8744 mL | 9.6860 mL | |
| 20 mM | 0.2906 mL | 1.4529 mL | 2.9058 mL | 7.2645 mL | |
| 25 mM | 0.2325 mL | 1.1623 mL | 2.3246 mL | 5.8116 mL | |
| 30 mM | 0.1937 mL | 0.9686 mL | 1.9372 mL | 4.8430 mL | |
| 40 mM | 0.1453 mL | 0.7264 mL | 1.4529 mL | 3.6322 mL | |
| 50 mM | 0.1162 mL | 0.5812 mL | 1.1623 mL | 2.9058 mL | |
| 60 mM | 0.0969 mL | 0.4843 mL | 0.9686 mL | 2.4215 mL | |
| 80 mM | 0.0726 mL | 0.3632 mL | 0.7264 mL | 1.8161 mL | |
| 100 mM | 0.0581 mL | 0.2906 mL | 0.5812 mL | 1.4529 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
sn-Glycerol 3-phosphate Related Classifications
HY-113128 Related Classifications
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