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Results for "

4-hydroxyphenylpyruvate dioxygenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HPPD (13) Apoptosis (1) Aurora Kinase (1) Bcl-2 Family (1) Endogenous Metabolite (1) Environmental Pollutants (2) Herbicide (6) Isotope-Labeled Compounds (2) PKA (1) Reactive Oxygen Species (ROS) (2) Reference Standards (3) STK33 (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (1) Metabolic Disease (7)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: HPPD Indoleamine 2,3-Dioxygenase (IDO) TET Protein

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-B0607

Nitisinone 2 Publications Verification NTBC; Nitisone; SC0735	HPPD	Metabolic Disease
Nitisinone is an orally active, competitive and reversible **4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀** of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

HY-135767

Bicyclopyrone	Environmental Pollutants HPPD	Metabolic Disease
Bicyclopyrone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (Hpd) .

HY-W010040

4-Hydroxyphenylpyruvic acid 1 Publications Verification	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase (HPPA). 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria .

HY-13495

ML281 2 Publications Verification	STK33 PKA Aurora Kinase Bcl-2 Family Apoptosis	Metabolic Disease Cancer
ML281 is a highly selective inhibitor of serine/threonine kinase 33 (STK33) with an IC₅₀ value of 14 nM. ML281 shows 700-fold selectivity over PKA and 550-fold over AurB. ML281 exerts core mechanism by inhibiting STK33: in small cell lung cancer, ML281 downregulates RPS6/BAD signaling phosphorylation, induces apoptosis, and suppresses proliferation, invasion . ML281 reduces STK33-mediated 4-hydroxyphenylpyruvate dioxygenase (HPD) phosphorylation in tyrosinemia . ML281 is suitable for research on STK33 function, KRAS mutation-related cancers (pancreatic cancer, colon cancer, lung adenocarcinoma, etc.), small cell lung cancer, and tyrosinemia-related damage

HY-W725385

Cypyrafluone Huanbifucaotong	HPPD	Others
Cypyrafluone is a 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor that prevents the homogentisic acid (HGA) production. Cypyrafluone can control weed in wheat fields .

HY-111957

Fenquinotrione	HPPD	Others
Fenquinotrione is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor with IC₅₀s of 27.2 and 44.7nM against rice and Arabidopsis thaliana HPPD, respectively. Fenquinotrione is an herbicide that can control a wide range of broadleaf and sedge weeds with excellent rice selectivity .

HY-144900

Topramezone	Environmental Pollutants Reactive Oxygen Species (ROS)	Others
Topramezone is a potent **4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor. Topramezone is a herbicide**, used for the post-emergence control of broadleaf and grass weeds in corn .

HY-161308

HPPD-IN-3	HPPD	Others
HPPD-IN-3 (compound 25) is a potent inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD), with IC50 of 10 nM, more potency than Mesotrione (HY-12853) .

HY-119989

Cyclopyrimorate	Herbicide	Infection
Cyclopyrimorate, a highly effective bleaching herbicide for weed control in rice fields, targets homogentisate solanesyltransferase (HST). HST is a downstream enzyme of 4-hydroxyphenylpyruvate dioxygenase in the plastoquinone (PQ) biosynthesis pathway .

HY-174423

Iptriazopyrid NC-656	Herbicide	Others
Iptriazopyrid (NC-656) is an azole carboxamide herbicide targeting 4-hydroxyphenylpyruvate dioxygenase (HPPD) with a K_i value of 24.3 nM for Arabidopsis HPPD and 33.3 nM for rice HPPD. Iptriazopyrid blocks plastoquinone and carotenoid synthesis, leading to weed chlorosis and death. Iptriazopyrid is promising for research of controlling weeds such as Echinochloa crus-galli in paddy fields .

HY-B0607R

Nitisinone (Standard) 2 Publications Verification NTBC (Standard); Nitisone (Standard); SC0735 (Standard)	HPPD Reference Standards	Metabolic Disease
Nitisinone (Standard) is the analytical standard of Nitisinone. This product is intended for research and analytical applications. Nitisinone is an orally active, competitive and reversible **4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀** of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

HY-175500

HPPD-IN-5	HPPD Herbicide	Others
HPPD-IN-5 (compound IV-45) is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor with an IC₅₀ of 0.21 μM. HPPD-IN-5 is used as a herbicide .

HY-163559

HPPD-IN-4	HPPD	Others
HPPD-IN-4 (Compound III-29) is a selective inhibitor of HPPD with anIC₅₀ of 0.19 μM. HPPD-IN-4 is primarily used in the study of high-efficiency herbicides .

HY-144900R

Topramezone (Standard)	Reference Standards Reactive Oxygen Species (ROS)	Others
Topramezone (Standard) is the analytical standard of Topramezone. This product is intended for research and analytical applications. Topramezone is a potent 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor. Topramezone is a herbicide, used for the post-emergence control of broadleaf and grass weeds in corn .

HY-135767R

Bicyclopyrone (Standard)	HPPD Reference Standards	Metabolic Disease
Bicyclopyrone (Standard) is the analytical standard of Bicyclopyrone. This product is intended for research and analytical applications. Bicyclopyrone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (Hpd) .

HY-B0607S

Nitisinone-d3 NTBC-d₃; Nitisone-d₃; SC0735-d₃	Isotope-Labeled Compounds HPPD	Metabolic Disease
Nitisinone-d₃ (NTBC-d₃) is deuterium labeled Nitisinone. Nitisinone is an orally active, competitive and reversible **4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀** of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

HY-W777526

Nitisinone-13C6	Isotope-Labeled Compounds	Others
Nitisinone- ¹³C₆ is a ¹³C-labeled Nitisinone (HY-B0607). Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

HY-W727532

Fenpyrazone	HPPD Herbicide	Others
Fenpyrazone is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor as well as a post-emergence herbicide. By inhibiting the activity of HPPD, Fenpyrazone indirectly blocks carotenoid biosynthesis in plants, causing bleaching of new tissues in sensitive plants, followed by necrosis and eventual death. Fenpyrazone is used in studies on controlling annual monocotyledonous and dicotyledonous weeds in summer maize fields .

HY-W1115537

Flusulfinam	HPPD Herbicide	Others
Flusulfinam is a HPPD inhibitor and herbicide, with an IC₅₀ of 0.0181 μM against Arabidopsis thaliana HPPD. Flusulfinam inhibits the catalytic activity of recombinant Arabidopsis thaliana HPPD. Flusulfinam exhibits potent herbicidal activity against barnyard grass (Echinochloa crus-galli). Flusulfinam inhibits the growth of Digitaria sanguinalis .

HY-W753209

Tolpyralate	Herbicide HPPD	Others
Tolpyralate is a selective post-emergence herbicide and corn Herbicide. Tolpyralate inhibits 4-HPPD. Tolpyralate exhibits herbicidal activity against a variety of weeds, including the glyphosate-resistant weed Amaranthus tuberculatus .

Art. -Nr.	Produktname	Category	Target	Chemical Structure

HY-W010040

4-Hydroxyphenylpyruvic acid 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase (HPPA). 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria .

Art. -Nr.	Compare	Produktname	Species	Source	Image

HY-P70024

	HPD/HPPDase Protein, Human (His) rHu4-hydroxyphenylpyruvate dioxygenase /HPD, His; 4-hydroxyphenylpyruvate dioxygenase; 4-Hydroxyphenylpyruvic Acid Oxidase; 4HPPD; HPD; HPPDase; HPD; PPD	Human	E. coli
	HPD is a key enzyme in tyrosine catabolism and plays a key role in catalyzing the conversion of 4-hydroxyphenylpyruvate into homogentisate. This enzymatic process represents a key step in the tyrosine metabolic pathway and contributes to the breakdown of this amino acid. HPD/HPPDase Protein, Human (His) is the recombinant human-derived HPD/HPPDase protein, expressed by E. coli , with N-6*His labeled tag.

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HY-B0607S

Nitisinone-d3
Nitisinone-d₃ (NTBC-d₃) is deuterium labeled Nitisinone. Nitisinone is an orally active, competitive and reversible **4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀** of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

Nitisinone-d3

Nitisinone-d₃ (NTBC-d₃) is deuterium labeled Nitisinone. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

HY-W777526

Nitisinone-13C6
Nitisinone- ¹³C₆ is a ¹³C-labeled Nitisinone (HY-B0607). Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IP (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

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HY-P83297

	HPDL Antibody (YA3042) 4-hydroxyphenylpyruvate dioxygenase like; GLOXD1; 4-HPPD-L	WB, IP	Human
	HPDL Antibody (YA3042) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HPDL.

HY-P83297A

	HPDL Antibody (YA3042)(PBS only) 4-hydroxyphenylpyruvate dioxygenase like; GLOXD1; 4-HPPD-L	WB, IP	Human
	HPDL Antibody (YA3042) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HPDL.

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