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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
ACSS2
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "ACSS2" in MCE Product Catalog:
9
9 Publications Verification
Target:
Research Areas:
Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 μM . Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV) [2].
5
5 Cited Publications
Target:
Research Areas:
VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer .
2
2 Cited Publications
Target:
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
ACSS2-IN-2 is an acyl-CoA synthetase short-chain family member 2 (ACSS2) inhibitor. ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer .
2
2 Cited Publications
Synonyms: (±)-Arabinose; DL-Arabinose; dl-Arabinose
1
1 Cited Publications
Cat. No.: HY-P701923
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACSS2; Acetyl-Coenzyme A Synthetase 2 (ADP Forming); Prev. ACAS2; Acetyl-CoA Synthetase; AceCS; Acetate--CoA Ligase; ACS; AceCS1; Acetyl-Coenzyme A Synthetase, Cytoplasmic; CDNA FLJ53719, Highly Similar To Acetyl-Coenzyme A Synthetase, Cytoplasmic (EC6.2.
Species:
Human
Source:
E. coli
Cat. No.: HY-N0059
CAS No.: 10323-20-3
Cat. No.: HY-W105310A
CAS No.: 14379-00-1
Synonyms: Nacr
Croconic acid disodium (Nacr) is a lysine crotonylation (Kcr) activator and electroactive material. Croconic acid disodium reduces the expression of HDAC2, HDAC3, SIRT1, and SIRT3, and increases the expression of EP300, CITED1, ACSS2, DPF2, CDYL, MLLT3, and YEATS2. Croconic acid disodium elevates intracellular crotonyl-CoA content and global histone lysine crotonylation levels. Croconic acid disodium promotes the growth of bovine fibroblasts, regulates cell cycle progression, and inhibits bovine fibroblast apoptosis (apoptosis). Croconic acid disodium improves the blastocyst development efficiency of bovine somatic cell nuclear transfer embryos. Croconic acid disodium undergoes reversible lithium intercalation/deintercalation reactions via sodium-lithium ion exchange. Croconic acid disodium is applicable to research related to cell growth promotion [2].
Cat. No.: HY-N7082
CAS No.: 28697-53-2
Cat. No.: HY-161117
CAS No.: 1497439-74-3
Target:
Research Areas:
AD-8007 is a blood-brain barrier-permeable ACSS2 inhibitor with human IC50 of 0.89 μM and Kd of 116.6 μM. AD-8007 reduces colony-forming ability, lipid storage levels and FASN protein expression, and induces cancer cell death. AD-8007 shrinks established tumors, acts synergistically with radiotherapy to inhibit tumor growth, reduces tumor burden, causes no obvious toxicity to normal brain tissue, and prolongs survival. AD-8007 exhibits superior metabolic stability. AD-8007 is applicable to research related to breast cancer brain metastasis .
Cat. No.: HY-RS00211
Target:
Research Areas:
ACSS2 Human Pre-designed siRNA Set A contains three designed siRNAs for ACSS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-161116
CAS No.: 2306525-79-9
Research Areas:
AD-5584 is a selective and blood-brain barrier-penetrant ACSS2 inhibitor (IC50 = 0.86 μM). AD-5584 binds to the nucleotide-binding pocket of ACSS2, blocking CoA binding and acetyl transfer through steric hindrance, thereby inhibiting the conversion of acetate to acetyl-CoA. AD-5584 decreases acetyl-CoA levels, lipid droplet content, FASN expression, E2F1, SLC7A11, and GPX4 levels, and reduces E2F1 occupancy at the SLC7A11 promoter. AD-5584 induces ferroptosis, lipid peroxidation, malondialdehyde accumulation, and cell death, and decreases clonogenic survival and proliferative capacity. AD-5584 can be used for research on breast cancer brain metastasis [2] .
Cat. No.: HY-145392
CAS No.: 2711039-08-4
Target:
Research Areas:
ACSS2-IN-1 is a potent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of <1 nM. ACSS2-IN-1 inhibits ACSS2 enzymatic activity, blocks the metabolic pathway converting acetate to acetyl-CoA in cancer cells, and thereby suppresses tumor energy metabolism, lipid synthesis and histone acetylation. ACSS2-IN-1 can be used in the research of cancer and hyperproliferative disorders .
Cat. No.: HY-RS16673
Target:
Research Areas:
Acss2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acss2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23108
Target:
Research Areas:
Acss2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Acss2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N7082R
CAS No.: 28697-53-2
Category:
Target:
Cat. No.: HY-N0059R
CAS No.: 10323-20-3
Target:
Cat. No.: HY-N0059S1
CAS No.: 139657-60-6
Cat. No.: HY-N0059S3
CAS No.: 101615-87-6
D-Arabinose- 13C-3 is the 13C-labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-Arabinose (HY-N7082) [2] .
Cat. No.: HY-P82238A
Synonyms: ACSS2; ACSA; ACAS2; AceCS; MYH7B; Acetyl CoA synthetase
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
