2306525-79-9
Chemical Structure
AD-5584
- CAS No.: 2306525-79-9
- Formula:C22H24ClFN4O
- Molecular Weight:414.90
InChIKey: PYZYZGZTKGCTOY-UHFFFAOYSA-N
SMILES: FC1=CC=C(C(N2CCCCC2)C(N(C)CC3=NC4=CC(Cl)=CC=C4N3)=O)C=C1
Biological Activity: AD-5584 is a selective and blood-brain barrier-penetrant ACSS2 inhibitor (IC50 = 0.86 μM). AD-5584 binds to the nucleotide-binding pocket of ACSS2, blocking CoA binding and acetyl transfer through steric hindrance, thereby inhibiting the conversion of acetate to acetyl-CoA. AD-5584 decreases acetyl-CoA levels, lipid droplet content, FASN expression, E2F1, SLC7A11, and GPX4 levels, and reduces E2F1 occupancy at the SLC7A11 promoter. AD-5584 induces ferroptosis, lipid peroxidation, malondialdehyde accumulation, and cell death, and decreases clonogenic survival and proliferative capacity. AD-5584 can be used for research on breast cancer brain metastasis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AD-5584 | 99.86% | AD-5584 is a selective and blood-brain barrier-penetrant ACSS2 inhibitor (IC50 = 0.86 μM). AD-5584 binds to the nucleotide-binding pocket of ACSS2, blocking CoA binding and acetyl transfer through steric hindrance, thereby inhibiting the conversion of acetate to acetyl-CoA. AD-5584 decreases acetyl-CoA levels, lipid droplet content, FASN expression, E2F1, SLC7A11, and GPX4 levels, and reduces E2F1 occupancy at the SLC7A11 promoter. AD-5584 induces ferroptosis, lipid peroxidation, malondialdehyde accumulation, and cell death, and decreases clonogenic survival and proliferative capacity. AD-5584 can be used for research on breast cancer brain metastasis. | ||||||||||||||||||||
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References
- [1]. Esquea EM, et al. Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells. Frontiers in pharmacology. 2024;15:1394685. [Content Brief]
- [2]. Esquea EM, et al. ACSS2 regulates ferroptosis in an E2F1-dependent manner in breast cancer brain metastatic cells. bioRxiv [Preprint]. 2024 Oct 21:2024.10.18.619082.
- [3]. Young RG, et al. ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis. Cancer research. 2026 Jul 15;86(14):3502-3518.
