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Aldehyde oxidase Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldehyde Oxidase (AO) (1) Monoamine Oxidase (2) Adenosine Receptor (1) Apoptosis (8) c-Met/HGFR (7) DNA Stain (2) GABA Receptor (2) Histone Demethylase (2) Interleukin Related (1) Isotope-Labeled Compounds (2) JAK (1) Parasite (2) Phosphodiesterase (PDE) (2) Reference Standards (4) Sodium Channel (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (4) Metabolic Disease (7) Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Aldehyde Oxidase (AO) Aldehyde Dehydrogenase (ALDH) Amino Acid Oxidase Serpin Lysyl Oxidase Glycolate Oxidase Xanthine Oxidase NADPH Oxidase Monoamine Oxidase Protoporphyrinogen IX oxidase VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13404

Capmatinib Maximum Cited Publications 24 Publications Verification INC280; INCB28060	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-13735

Quinacrine 5+ Cited Publications Acriquine	Parasite Sodium Channel DNA Stain Apoptosis Aldehyde Oxidase (AO)	Infection Neurological Disease Cancer
Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human **aldehyde oxidase (IC₅₀**: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm) .

HY-B1018A

Phenelzine sulfate 5+ Cited Publications	Monoamine Oxidase GABA Receptor Histone Demethylase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active *monoamine oxidase* (MAO-A and MAO-B)** inhibitor. Phenelzine sulfate inhibits GABA transaminase and *primary amine oxidase* (PrAO)*, and sequester reactive aldehydes. Phenelzine sulfate also inhibits* LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-13404C

Capmatinib dihydrochloride hydrate Maximum Cited Publications 24 Publications Verification INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-I0637

Isovanillin 1 Publications Verification 3-Hydroxy-4-methoxybenzAldehyde	Others	Neurological Disease Metabolic Disease
Isovanillin is an **aldehyde oxidase** inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-B0051

Carbazeran	Phosphodiesterase (PDE)	Metabolic Disease
Carbazeran, a potent phosphodiesterase inhibitor, is aldehyde oxidase substrate. Carbazeran can be used for the research of metabolic disease .

HY-13404A

Capmatinib dihydrochloride Maximum Cited Publications 24 Publications Verification INC280 dihydrochloride; INCB28060 dihydrochloride	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) dihydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib dihydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-13404B

Capmatinib hydrochloride Maximum Cited Publications 24 Publications Verification INC280 hydrochloride; INCB-28060 hydrochloride	c-Met/HGFR Apoptosis	Cancer
Capmatinib (INC280; INCB28060) hydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib hydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib hydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib hydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-I0637S

Isovanillin-d3 3-Hydroxy-4-methoxybenzAldehyde-d₃	Isotope-Labeled Compounds	Metabolic Disease
Isovanillin-d₃ is the deuterium labeled Isovanillin . Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-B1018AS

Phenelzine-d5 sulfate	Isotope-Labeled Compounds Monoamine Oxidase GABA Receptor Histone Demethylase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active *monoamine oxidase* (MAO-A and MAO-B)** inhibitor. Phenelzine sulfate inhibits GABA transaminase and *primary amine oxidase* (PrAO)*, and sequester reactive aldehydes. Phenelzine sulfate also inhibits* LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-13735R

Quinacrine (Standard) Acriquine (Standard)	Parasite Sodium Channel DNA Stain Apoptosis Reference Standards	Infection Neurological Disease Cancer
Quinacrine (Standard) is the analytical standard of Quinacrine. This product is intended for research and analytical applications. Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm) .

HY-13404R

Capmatinib (Standard) INC280 (Standard); INCB28060 (Standard)	Reference Standards c-Met/HGFR Apoptosis	Cancer
Capmatinib (Standard) is the analytical standard of Capmatinib. This product is intended for research and analytical applications. Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC₅₀=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-108680

Carbazeran citrate	Phosphodiesterase (PDE)	Metabolic Disease
Carbazeran (citrate), a potent phosphodiesterase inhibitor, is aldehyde oxidase substrate. Carbazeran (citrate) can be used for the research of metabolic disease .

HY-I0637R

Isovanillin (Standard) 3-Hydroxy-4-methoxybenzAldehyde (Standard)	Reference Standards Others	Neurological Disease Metabolic Disease
Isovanillin (Standard) is the analytical standard of Isovanillin. This product is intended for research and analytical applications. Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-50683S

JNJ-38877605-d1	c-Met/HGFR	Cancer
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 .

HY-144075

JAK-IN-19	JAK	Inflammation/Immunology
JAK-IN-19 is a potent JAK inhibitor (PBMC IFNγ pIC₅₀=7.2 and HLF Eotaxin pIC₅₀=7.7). JAK-IN-19 has good retentive properties in the lung via mitigating being metabolized by Aldehyde Oxidase (AO), with diminished VEGFR2 selectivity (VEGFR2 pIC₅₀=7.0, Aurora B pIC₅₀=5.8) .

HY-13404CR

Capmatinib dihydrochloride hydrate (Standard) INC280 dihydrochloride hydrate (Standard); INCB-28060 dihydrochloride hydrate (Standard)	c-Met/HGFR Apoptosis Reference Standards	Cancer
Capmatinib (dihydrochloride hydrate) (Standard) is the analytical standard of Capmatinib (dihydrochloride hydrate). This product is intended for research and analytical applications. Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase .

HY-404647

FK3453	Interleukin Related Adenosine Receptor	Neurological Disease Inflammation/Immunology
FK3453 is a dual adenosine A1/A2 inhibitor and a TSLP inhibitor. FK3453 is also a substrate of aldehyde oxidase (AO). FK3453 can inhibit the production of TSLP and IL-33. FK3453 is useful for research on Parkinson’s disease and allergic disorders .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-I0637

Isovanillin 1 Publications Verification 3-Hydroxy-4-methoxybenzAldehyde	Monophenols Ketones, Aldehydes, Acids Asclepiadaceae Phenols Plants Periploca sepium Bunge Source Classification	Others
Isovanillin is an **aldehyde oxidase** inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-I0637R

Isovanillin (Standard) 3-Hydroxy-4-methoxybenzAldehyde (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Asclepiadaceae Phenols Plants Periploca sepium Bunge Source Classification	Reference Standards Others
Isovanillin (Standard) is the analytical standard of Isovanillin. This product is intended for research and analytical applications. Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .

Cat. No.	Product Name	Chemical Structure

HY-I0637S

Isovanillin-d3
Isovanillin-d₃ is the deuterium labeled Isovanillin . Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-B1018AS

Phenelzine-d5 sulfate
Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active *monoamine oxidase* (MAO-A and MAO-B)** inhibitor. Phenelzine sulfate inhibits GABA transaminase and *primary amine oxidase* (PrAO)*, and sequester reactive aldehydes. Phenelzine sulfate also inhibits* LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

Phenelzine-d5 sulfate

Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-50683S

JNJ-38877605-d1
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 .

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