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Asialoglycoprotein Receptor (ASGPR)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Asialoglycoprotein Receptor (ASGPR) (4) C-type Lectin-like Receptors (CTLRs) (1) Drug Intermediate (1) Liposome (2) LYTACs (11) Nucleoside Antimetabolite/Analog (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (3) Inflammation/Immunology (1) Metabolic Disease (3)
Oligonucleotides:	Pegylated Lipids (1) siRNA drugs (2) Cholesterol (1) siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Recombinant Proteins

Oligonucleotides

Targets Recommended: Asialoglycoprotein Receptor (ASGPR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148118A

Tri-GalNAc(OAc)3 TFA	LYTACs	Cancer
Tri-GalNAc(OAc)3 TFA is a trivalent N-acetylgalactosamine (GalNAc) derivative that can be used to synthesize GalNAc-LYTAC. Tri-GalNAc is a specific ligand targeting the asialoglycoprotein receptor (ASGPR), mediating the endocytosis and transport of cell surface proteins (such as EGFR, HER2) to lysosomes for degradation by lysosomal targeting chimeras (LYTACs). Tri-GalNAc significantly reduces the level of target proteins and inhibits downstream signaling pathways (such as EGFR-mediated Akt and MAPK signals). Tri-GalNAc(OAc)3 TFA can be used for hepatocyte targeting studies, and can degrade carcinogenic membrane proteins and inhibit tumor cell proliferation in liver cancer cell models .

HY-139482

tri-GalNAc-COOH	LYTACs	Cancer
tri-GalNAc-COOH is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research .

HY-157950

DSPE-PEG2000-triGalNAc ammonium	Liposome	Cancer
DSPE-PEG2K-triGalNAc ammonium is a polar lipid composed of DSPE and tri-N-acetylgalactosamine that can be used to construct liposomes target to asialoglycoprotein receptor (ASGPR).

HY-147354

TriGalNAc CBz	LYTACs	Cardiovascular Disease
TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies .

HY-147012

GalNAc-L96	Drug Intermediate	Others
GalNAc-L96, a triantennary N-acetylgalactosamine (GalNAc), is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-L96 can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery .

HY-173247

GalNAc-NAG37 phosphoramidite	C-type Lectin-like Receptors (CTLRs)	Others
GalNAc-NAG37 phosphoramidite is an N-acetylgalactosamine (GalNAc) derivative that acts as a ligand for the asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and for oligonucleotide delivery .

HY-147102

tri-GalNAc biotin	LYTACs	Metabolic Disease
tri-GalNAc biotin is a biotinylated *ASGPR* (Asialoglycoprotein receptor) ligand. tri-GalNAc biotin promotes cellular uptake of neutravidin (NA) via ASGPR. tri-GalNAc biotin delivers neutravidin to lysosomes for degradation. tri-GalNAc biotin can be used for research of LYsosome TArgeting Chimera (LYTAC) .

HY-150151A

GalNac-siRNA negative control (21nt)	LYTACs	Cardiovascular Disease
GalNac-siRNA negative control (21nt) is the negative control form of GalNac-siRNA. GalNac-siRNA is an Asialoglycoprotein receptor (ASGPR)-targeted inhibitor conjugate. GalNac-siRNA is promising for research of hereditary transthyretin amyloidosis, acute hepatic porphyria, hemophilia and hypercholesterolemia .

HY-156994

ASGPR ligand-1	Asialoglycoprotein Receptor (ASGPR)	Others
ASGPR ligand-1 (Compound int-CC2) is an asialoglycoprotein receptor (ASGPR) ligand with a binding K_d value of 0.9 nM. ASGPR ligand-1 is applicable to research on lysosome degradation-related diseases .

HY-171910

tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12)	Asialoglycoprotein Receptor (ASGPR) LYTACs	Others
tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12) is an **asialoglycoprotein receptor (ASGPR)** ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research .

HY-179737

ASGPR ligand-2	LYTACs	Metabolic Disease
ASGPR ligand-2 (Compound 366) is an asialoglycoprotein receptor (ASGPR) binder. ASGPR ligand-2 can be coupled with recognition elements of target proteins (such as antibodies or antigen-binding fragments), and through the endocytosis mediated by ASGPR, the target protein is delivered to the lysosomes of liver cells, promoting the degradation of the target protein. ASGPR ligand-2 can be used for the research of metabolic disease .

HY-142881

D-MoDE-A (1)	LYTACs	Others
D-MoDE-A (1) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).

HY-153527

GalNac-L96 analog	LYTACs	Metabolic Disease
GalNAc-L96 analog is an intermediate in the synthesis of the asialoglycoprotein receptor (ASGPR) ligand GalNAc-L96 (HY-147012).

HY-145649A

Zilebesiran sodium AD-85481 sodium; ALN-AGT sodium	Small Interfering RNA (siRNA) Asialoglycoprotein Receptor (ASGPR)	Cardiovascular Disease
Zilebesiran (AD-85481; ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. Zilebesiran sodium binds to the hepatic asialoglycoprotein receptor (ASGPR), activates the RNA-induced silencing complex to degrade hepatic angiotensinogen mRNA, thereby inhibiting the gene expression and synthesis of angiotensinogen. Zilebesiran sodium dose-dependently reduces serum angiotensinogen levels and 24-hour ambulatory blood pressure, with its effect persisting throughout the circadian cycle. Zilebesiran sodium is applicable to research related to hypertension .

HY-142885

M-MoDE-A (2)	LYTACs	Others
M-MoDE-A (2) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).

HY-112752

Gal-C4-Chol	Liposome	Others
Gal-C4-Chol is a glycosylated cholesterol derivative. Gal-C4-Chol can be used as a ligand for asialoglycoprotein receptors (ASGPR) to prepare Galactosylated (Gal) liposomes. Gal-C4-Chol can be used to prepare simple lipid-based nanoparticles .

HY-19272

OGT-719	Nucleoside Antimetabolite/Analog Asialoglycoprotein Receptor (ASGPR)	Cancer
OGT-719 is a potent, orally active nucleoside analogue that targets the **asialoglycoprotein receptor** (ASGP-R). OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research .

HY-171342

Mal-C2-amide-C10-tri-GalNAc	LYTACs	Inflammation/Immunology
Mal-C2-amide-C10-tri-GalNAc (Compound 1226) is an asialoglycoprotein receptor (ASGPR) binding ligand fragment and a component of lysosome-targeted bifunctional molecules. Mal-C2-amide-C10-tri-GalNAc promotes the sequestration and degradation of extracellular target molecules in lysosomes. Mal-C2-amide-C10-tri-GalNAc is used in the research of autoimmune diseases .

Cat. No.	Product Name	Type

HY-173247

GalNAc-NAG37 phosphoramidite	Biochemical Assay Reagents
GalNAc-NAG37 phosphoramidite is an N-acetylgalactosamine (GalNAc) derivative that acts as a ligand for the asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and for oligonucleotide delivery .

HY-112752

Gal-C4-Chol	Biochemical Assay Reagents
Gal-C4-Chol is a glycosylated cholesterol derivative. Gal-C4-Chol can be used as a ligand for asialoglycoprotein receptors (ASGPR) to prepare Galactosylated (Gal) liposomes. Gal-C4-Chol can be used to prepare simple lipid-based nanoparticles .

Species:	Human (3) Mouse (4) Rat (1)
Tag:	SUMO (1) His (6) Fc (2)
Source:	HEK293 (7) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705990

	ASGR1/ASGPR1 Protein, Rat (HEK293, His) Asialoglycoprotein Receptor 1; ASGP-R 1; ASGPR 1; Hepatic lectin 1; HL-1; rHL-1	Rat	HEK293

HY-P75498

	ASGR1/ASGPR1 Protein, Mouse (HEK293, His) ASGPR; ASGPR1; ASGR1; Asialoglycoprotein Receptor 1; CLEC4H1; Hepatic lectin H1; MHL1	Mouse	HEK293
	ASGR1/ASGPR1 proteins play a crucial role in cellular processes by mediating endocytosis of desialylated plasma glycoproteins and recognizing terminal galactose and N-acetylgalactosamine. It promotes ligand internalization and formation of complexes that are transported to sorting organelles. ASGR1/ASGPR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ASGR1/ASGPR1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P704414

	ASGR1/ASGPR1 Protein, Mouse (HEK293, hFc) ASGPR; ASGPR1; ASGR1; Asialoglycoprotein Receptor 1; CLEC4H1; Hepatic lectin H1; MHL1	Mouse	HEK293
	ASGR1/ASGPR1 proteins play a crucial role in cellular processes by mediating endocytosis of desialylated plasma glycoproteins and recognizing terminal galactose and N-acetylgalactosamine. It promotes ligand internalization and formation of complexes that are transported to sorting organelles. ASGR1/ASGPR1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived ASGR1/ASGPR1 protein, expressed by HEK293, with N-hFc labeled tag.

HY-P77555

	ASGR1/ASGPR1 Protein, Mouse (Biotinylated, HEK293, His) ASGPR; ASGPR1; ASGR1; Asialoglycoprotein Receptor 1; CLEC4H1; Hepatic lectin H1; MHL1	Mouse	HEK293
	ASGR1/ASGPR1 proteins play a crucial role in cellular processes by mediating endocytosis of desialylated plasma glycoproteins and recognizing terminal galactose and N-acetylgalactosamine. It promotes ligand internalization and formation of complexes that are transported to sorting organelles. ASGR1/ASGPR1 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived ASGR1/ASGPR1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P72091

	ASGR2/ASGPR2 Protein, Mouse (His-SUMO) Asgr2; Asgr-2; Asialoglycoprotein Receptor 2; ASGP-R 2; ASGPR 2; Hepatic lectin 2; HL-2; mHL-2	Mouse	E. coli
	ASGR2/ASGPR2 proteins are critical in cellular processes, mediating the endocytosis of desialylated plasma glycoproteins. It recognizes terminal galactose and N-acetylgalactosamine, promotes ligand internalization, and forms complexes that are transported to sorting organelles. ASGR2/ASGPR2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived ASGR2/ASGPR2 protein, expressed by E. coli , with N-10*His, N-SUMO labeled tag.

HY-P76736

	ASGR2/ASGPR2 Protein, Human (HEK293, His) 1 Publications Verification Asgr2; Asgr-2; Asialoglycoprotein Receptor 2; ASGP-R 2; ASGPR 2; Hepatic lectin 2; HL-2; mHL-2	Human	HEK293
	ASGR2 mediates endocytosis of desialylated glycoproteins, recognizing galactose and N-acetylgalactosamine units. Ligand binding leads to internalization and sorting organelle transport, followed by receptor return to the cell membrane. The receptor is suggested to function as a dimer. ASGR2 also interacts with LASS2. ASGR2/ASGPR2 Protein, Human (HEK293, His) is the recombinant human-derived ASGR2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P7610

	ASGR1/ASGPR1 Protein, Human (HEK293, His) 1 Publications Verification rHuASGR1, His; Asialoglycoprotein Receptor 1, ASGR1,	Human	HEK293
	ASGR1/ASGPR1 Protein, Human (HEK293, His), a recombinant human Asialoglycoprotein Receptor 1 produced in HEK293 cells, has a His tag. Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells.

HY-P704413

	ASGR1/ASGPR1 Protein, Human (HEK293, hFc) rHuASGR1, His; Asialoglycoprotein Receptor 1, ASGR1,	Human	HEK293
	ASGR1/ASGPR1 mediates endocytosis of desialylated glycoproteins, recognizing galactose and N-acetylgalactosamine units. Ligand binding leads to internalization and sorting organelle transport, followed by receptor return to the cell membrane. ASGR1/ASGPR1 interacts with LASS2. ASGR1/ASGPR1 Protein, Human (HEK293, hFc) is the recombinant human-derived ASGR1/ASGPR1 protein, expressed by HEK293, with N-hFc labeled tag.

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Cat. No.	Product Name		Classification

HY-157950

DSPE-PEG2000-triGalNAc ammonium		Pegylated Lipids
DSPE-PEG2K-triGalNAc ammonium is a polar lipid composed of DSPE and tri-N-acetylgalactosamine that can be used to construct liposomes target to asialoglycoprotein receptor (ASGPR).

HY-150151A

GalNac-siRNA negative control (21nt)		siRNAs siRNA drugs
GalNac-siRNA negative control (21nt) is the negative control form of GalNac-siRNA. GalNac-siRNA is an Asialoglycoprotein receptor (ASGPR)-targeted inhibitor conjugate. GalNac-siRNA is promising for research of hereditary transthyretin amyloidosis, acute hepatic porphyria, hemophilia and hypercholesterolemia .

HY-145649A

Zilebesiran sodium AD-85481 sodium; ALN-AGT sodium		siRNAs siRNA drugs
Zilebesiran (AD-85481; ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. Zilebesiran sodium binds to the hepatic asialoglycoprotein receptor (ASGPR), activates the RNA-induced silencing complex to degrade hepatic angiotensinogen mRNA, thereby inhibiting the gene expression and synthesis of angiotensinogen. Zilebesiran sodium dose-dependently reduces serum angiotensinogen levels and 24-hour ambulatory blood pressure, with its effect persisting throughout the circadian cycle. Zilebesiran sodium is applicable to research related to hypertension .

HY-112752

Gal-C4-Chol		Cholesterol
Gal-C4-Chol is a glycosylated cholesterol derivative. Gal-C4-Chol can be used as a ligand for asialoglycoprotein receptors (ASGPR) to prepare Galactosylated (Gal) liposomes. Gal-C4-Chol can be used to prepare simple lipid-based nanoparticles .

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