32 Results for "

CLPP

" in MedChemExpress (MCE) Product Catalog:
Products (32)

32 Results for "CLPP" in MCE Product Catalog:

  • Targets Recommended:
6
Hinokiflavone
Hinokiflavone
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6 Publications Verification
Cat. No.: HY-N2360
CAS No.: 19202-36-9
Category:  

Flavonoids Phenols Polyphenols Selaginellaceae Plants Disease Research Fields Selaginella tamariscina (P. Beauv.) Spring Biflavones Cancer

Target:  

E1/E2/E3 Enzyme Apoptosis MMP ClpP

Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .
2
Tamarixetin
Tamarixetin
0 Images
2 Cited Publications
Cat. No.: HY-N1181
CAS No.: 603-61-2
Synonyms: 4'-O-Methyl Quercetin
Category:  

Flavonols Tamarix chinensis Lour. Plants Endogenous metabolite Tamaricaceae Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species (ROS)

Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .
2
(3R,4R)-A2-32-01
(3R,4R)-A2-32-01
0 Images
2 Cited Publications
Cat. No.: HY-111532
CAS No.: 1359752-95-6
Purity:  99.73%
Target:  

ClpP Bacterial

Research Areas:  

Infection

(3R,4R)-A2-32-01 (compound 24(R,R)), the (R,R)-enantiomer of A2-32-01, is a Staphylococcus aureus caseinolytic protease (SaClpP) inhibitor .
Z-GGF-CMK
Z-GGF-CMK
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Cat. No.: HY-P4284
CAS No.: 35172-59-9
Target:  

Proteasome ClpP Bacterial

Research Areas:  

Infection

Z-GGF-CMK is an Antibacterial agent, an inhibitor of the ClpP1P2 serine protease complex (with an IC50 of 50 μM against intracellular ClpP1P2 protease activity in Mycobacterium bovis BCG), and a selective inhibitor of the mycobacterial Proteasome (with an IC50 of 50 μM against the proteasome in M. bovis BCG). Z-GGF-CMK inhibits the growth of mycobacteria. Z-GGF-CMK exhibits cytotoxic activity against liver cancer cells. Z-GGF-CMK can be used in the research of tuberculosis .
DCEM1
DCEM1
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Cat. No.: HY-171616
CAS No.: 878949-21-4
Target:  

HSP β-catenin

Research Areas:  

Cancer

DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction of HSP60 with ClpP, thereby blocking the mitochondrial unfolded protein response. DCEM1 inhibits β-catenin expression and ATP production in PC-3 and TKO cells. DCEM1 can be used in prostate cancer research .
ClpP modulator-1
ClpP modulator-1
0 Images
Cat. No.: HY-175597
CAS No.: 2363753-48-2
Target:  

ClpP

Research Areas:  

Infection

ClpP modulator-1 (Compound BC8a), a peptidomimetic, is an allosteric ClpP modulator. ClpP modulator-1 is a ClpP activator at low concentration with EC50s of 0.35 and 0.58  μM for for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP), resepectively. ClpP modulator-1 also inhibits peptidase activity at high concentration by competitively inhibiting substrate protein (LY-AMC) binding to ClpP C sites. ClpP modulator-1 has antibacterial activity. ClpP modulator-1 can be used for bacterial infections research .
CLPP-2068
CLPP-2068
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Cat. No.: HY-173048
CAS No.: 3104462-62-3
Target:  

ClpP Apoptosis Reactive Oxygen Species (ROS)

Research Areas:  

Cancer

CLPP-2068 is the orally active activator for human caseinolytic protease P (HsClpP) with an EC50 of 50.4 nM. CLPP-2068 exhibits anti-proliferative efficacy in OCI-LY10 cancer cell with an IC50 of 5.2 nM. CLPP-2068 decreases mitochondrial membrane potential, increases mitochondrial ROS levels, and induces mitochondrial dysfunction. CLPP-2068 arrests the cell cycle at G1 phase, and induces apoptosis in cell OCI-LY10. CLPP-2068 exhibits antitumor activity in mouse xenograft models .
(3S,4S)-A2-32-01
(3S,4S)-A2-32-01
0 Images
Cat. No.: HY-111532B
Purity:  98.15%
Target:  

ClpP

Research Areas:  

Infection

(3S,4S)-A2-32-01 (compound 24(S,S)), a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protein proteases (ClpP) inhibitor .
ZK53
ZK53
0 Images
Cat. No.: HY-149677
CAS No.: 3031789-26-8
Purity:  98.94%
Target:  

Mitochondrial Metabolism

Research Areas:  

Cancer

ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37?μM for α-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model .
ADEP-14
ADEP-14
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Cat. No.: HY-175595
CAS No.: 1846579-07-4
Synonyms: ADEP26
Target:  

ClpP Bacterial

Research Areas:  

Infection

ADEP-14 (ADEP26) is a ClpP activator. ADEP-14 exhibits antibacterial activity against Gram-negative and Gram-positive bacteria. ADEP-14 can be used in studies related to bacterial infections .
ZG36
ZG36
0 Images
Cat. No.: HY-155556
CAS No.: 2999673-34-4
Target:  

ClpP

Research Areas:  

Cancer

ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model .
ACP1-01
ACP1-01
0 Images
Cat. No.: HY-175596
CAS No.: 1382489-31-7
Target:  

ClpP Bacterial

Research Areas:  

Infection

ACP1-01 is a bacterial ClpP activator with EC50s of 3.4 and 2.6  μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP). ACP1-01 noncovalently binds to ClpP C sites and activates the protease. ACP1-01 has antibacterial activity. ACP1-01 can be used for bacterial infections research .
MS6076
MS6076
0 Images
Cat. No.: HY-178749
Target:  

ClpP Mitochondrial Metabolism Apoptosis Caspase PARP

Research Areas:  

Cancer

MS6076 is a mitochondrial protease ClpP agonist. MS6076 specifically activates the ClpP protease in the mitochondrial matrix, significantly disrupting mitochondrial Electron Transport Chain (ETC) function by accelerating the degradation of unfolded proteins. MS6076 exhibits potent cytotoxicity against a variety of cancer cell lines. MS6076 induces cell apoptosis, increasing cleavage of caspase 3 and PARP. MS6076 can be used for the research of breast cancer .
HsClpP activator-1
HsClpP activator-1
0 Images
Cat. No.: HY-176427
CAS No.: 3087033-83-5
Target:  

ClpP

Research Areas:  

Cancer

HsClpP activator-1 (compound 24) is a potent HsClpP activator with an EC50 of 0.22 μM. HsClpP activator-1 effectively inhibits cancer cell growth with IC50 values of 0.1-1 μM .
Tamarixetin (Standard)
Tamarixetin (Standard)
0 Images
Cat. No.: HY-N1181R
CAS No.: 603-61-2
Synonyms: 4'-O-Methyl Quercetin (Standard)
Category:  

Flavonols Tamaricaceae Flavonoids Tamarix chinensis Lour. Phenols Polyphenols Plants Endogenous metabolite

Target:  

Reference Standards Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species (ROS)

Tamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .
Hinokiflavone (Standard)
Hinokiflavone (Standard)
0 Images
Cat. No.: HY-N2360R
CAS No.: 19202-36-9
Category:  

Flavonoids Phenols Polyphenols Selaginellaceae Plants Selaginella tamariscina (P. Beauv.) Spring Biflavones

Target:  

Reference Standards E1/E2/E3 Enzyme Apoptosis MMP ClpP

Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .
Z-Gly-Gly-Leu-AMC
Z-Gly-Gly-Leu-AMC
0 Images
Cat. No.: HY-P4399
CAS No.: 97792-39-7
Target:  

Bacterial ClpP

Research Areas:  

Others

Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .
ACP1b
ACP1b
0 Images
Cat. No.: HY-126046
CAS No.: 1371635-84-5
Target:  

ClpP Bacterial

Research Areas:  

Infection

ACP1b is an activator for ClpP protease with Kd of 3.2 μM, and exhibits antibacterial activity. ACP1b inhibits N. meningitidis and H. influenzae with MBC of 16 and 8 μg/mL .
(R)-ZG197
(R)-ZG197
0 Images
Cat. No.: HY-152096
CAS No.: 2999672-72-7
Target:  

ClpP Bacterial

Research Areas:  

Infection

(R)-ZG197 is a highly selective Staphylococcus aureus Caseinolytic protease P (SaClpP) activator with an EC50 of 1.5 μM. (R)-ZG197 also activates Homo sapiens ClpP (HsClpP) with an EC50 of 31.4 μM .
Anti-MRSA agent 39
Anti-MRSA agent 39
0 Images
Cat. No.: HY-178912
Target:  

Reactive Oxygen Species (ROS) Bacterial ClpP

Research Areas:  

Infection Inflammation/Immunology

Anti-MRSA agent 39 is an orally active ClpX modulator that binds Staphylococcus aureus caseinolytic protease X (SaClpX) with high affinity (Kd = 3.6 μM). Anti-MRSA agent 39 exerts antibacterial effects through temperature-dependent inhibition of cell division. Anti-MRSA agent 39 elicits profound metabolic dysregulation in methicillin-resistant Staphylococcus aureus (MRSA), manifesting as significantly reduced ATP levels, elevated reactive oxygen species (ROS), and decreased NAD+/NADH ratio, and accelerates bacterial lysis rates in MRSA ATCC 33591. Anti-MRSA agent 39 significantly increases the proportion of MRSA cells in the mitotic phase, and the cells exhibit obvious morphological abnormalities. Anti-MRSA agent 39 can be used for the study of invasive MRSA infections .
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