878949-21-4
878949-21-4
Chemical Structure
DCEM1
- CAS No.: 878949-21-4
- Formula:C22H23N3O2S
- Molecular Weight:393.50
SMILES: CCOC1=CC(CNCC2=NC3=C(N2)C=CC=C3)=CC=C1OCC4=CC=CS4
Biological Activity: DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction of HSP60 with ClpP, thereby blocking the mitochondrial unfolded protein response. DCEM1 inhibits β-catenin expression and ATP production in PC-3 and TKO cells. DCEM1 can be used in prostate cancer research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DCEM1 | 99.31% | DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction of HSP60 with ClpP, thereby blocking the mitochondrial unfolded protein response. DCEM1 inhibits β-catenin expression and ATP production in PC-3 and TKO cells. DCEM1 can be used in prostate cancer research. | ||||||||||||||||||||
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References
- [1]. Dhyan C, et al. Methods for disrupting mitochondrial unfolded protein response. WO2022103897. WIPO (PCT). 2021-11-10.
- [2]. Woytash JA, et al. Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer. Oncogene. 2025 Apr;44(12):820-834. [Content Brief]
Keywords
