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CTX-II

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Inhibitors & Agonists

1

Biochemical Assay Reagents

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-NP003
    Collagen, Type II, from bovine snout membrane
    2 Publications Verification

    Collagen

    		 Collagen Inflammation/Immunology
    Collagen, Type II, from bovine snout membrane is a type II collagen that can be used for cell culture . This product is enzymatically hydrolyzed collagen peptides.
    Collagen, Type II, from bovine snout membrane
  • HY-183764
    COX-2/5-LOX-IN-8

    		COX Lipoxygenase TNF Receptor Interleukin Related MMP Inflammation/Immunology
    COX-2/5-LOX-IN-8 is an orally active dual COX-2/5-LOX inhibitor, with an IC50 of 6.30 μM against sheep-derived COX-2 and an IC50 of 8.09 μM against 5-LOX. COX-2/5-LOX-IN-8 acts as a membrane stabilizer that stabilizes erythrocyte membranes against hypotonicity-induced hemolysis. COX-2/5-LOX-IN-8 functions as a protein stabilizer that inhibits heat-induced denaturation of bovine serum albumin. COX-2/5-LOX-IN-8 reduces paw swelling, improves hind limb weight-bearing function, decreases serum levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, CRP), and lowers serum levels of cartilage degradation biomarkers (COMP, MMP-3, CTX-II). COX-2/5-LOX-IN-8 can be used in the research of osteoarthritis .
    COX-2/5-LOX-IN-8

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