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Results for "

Ca2 binding

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (23) Calmodulin (6) CaMK (1) Adrenergic Receptor (1) Antibiotic (2) Apoptosis (4) Autophagy (2) Bacterial (7) Bcl-2 Family (2) Beta-lactamase (2) Biochemical Assay Reagents (2) CCR (3) Chloride Channel (1) Complement System (1) COX (2) CXCR (2) Drug Metabolite (1) Endogenous Metabolite (3) Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (1) Environmental Pollutants (3) Fluorescent Dye (29) HIV (2) iGluR (4) Isotope-Labeled Compounds (5) Lipoxygenase (2) MDM-2/p53 (1) mGluR (2) MHC (1) mTOR (1) Neurokinin Receptor (1) Phosphodiesterase (PDE) (2) Phospholipase (3) PKC (3) Potassium Channel (1) Prostaglandin Receptor (3) Reactive Oxygen Species (ROS) (2) Reference Standards (3) Ser/Thr Kinase (1) Ser/Thr Protease (1) Sodium Channel (6)
By Research Areas:	Cancer (28) Cardiovascular Disease (7) Endocrinology (2) Infection (8) Inflammation/Immunology (14) Metabolic Disease (6) Neurological Disease (25)

By Targets:

Calcium Channel (23)

Calmodulin (6)

CaMK (1)

Adrenergic Receptor (1)

Antibiotic (2)

Apoptosis (4)

Autophagy (2)

Bacterial (7)

Bcl-2 Family (2)

Beta-lactamase (2)

Biochemical Assay Reagents (2)

CCR (3)

Chloride Channel (1)

Complement System (1)

COX (2)

CXCR (2)

Drug Metabolite (1)

Endogenous Metabolite (3)

Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (1)

Environmental Pollutants (3)

Fluorescent Dye (29)

HIV (2)

iGluR (4)

Isotope-Labeled Compounds (5)

Lipoxygenase (2)

MDM-2/p53 (1)

mGluR (2)

MHC (1)

mTOR (1)

Neurokinin Receptor (1)

Phosphodiesterase (PDE) (2)

Phospholipase (3)

PKC (3)

Potassium Channel (1)

Prostaglandin Receptor (3)

Reactive Oxygen Species (ROS) (2)

Reference Standards (3)

Ser/Thr Kinase (1)

Ser/Thr Protease (1)

Sodium Channel (6)

By Research Areas:

Cancer (28)

Cardiovascular Disease (7)

Endocrinology (2)

Infection (8)

Inflammation/Immunology (14)

Metabolic Disease (6)

Neurological Disease (25)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Neomycin sulfate 65+ Cited Publications	Environmental Pollutants Antibiotic Phospholipase Bacterial	Infection Metabolic Disease Cancer
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer .

Dizocilpine 40+ Cited Publications MK-801	iGluR	Neurological Disease
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a K_d of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca ²⁺ flux .

Benzocaine 1 Publications Verification	Environmental Pollutants Sodium Channel Bacterial	Infection Neurological Disease
Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

α-Lactalbumin	Bacterial	Infection Neurological Disease
α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca ²⁺, Mg ²⁺, Mn ²⁺, Na ⁺, K ⁺ and Zn ²⁺ ions; among these, Ca ²⁺ binding enhances protein stability, while Zn ²⁺ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions .

Neomycin	Antibiotic Phospholipase	Infection Cancer
Neomycin, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin is a known phospholipase C (PLC) inhibitor. Neomycin potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin can be used for the research of cancer .

Concanavalin A-HRP Con A-HRP	Fluorescent Dye	Cancer
Concanavalin A-HRP (Con A-HRP) is a HRP-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

S107 1 Publications Verification	Calcium Channel	Cardiovascular Disease
S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca ²⁺ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold .

Calcium Green-5N AM	Fluorescent Dye Calcium Channel	Neurological Disease
Calcium Green-5N AM is a *Ca ²⁺*-sensitive fluorescent probe (K_d = 14 μM). Calcium Green-5N AM shows enhanced fluorescence intensity upon binding to Ca ²⁺, and it can monitor free Ca ²⁺ in neurons .

Arsenazo III	Fluorescent Dye	Others
Arsenazo III is an azo derivative of chromotropic acid, a metal chrome dye, a chelating agent, and a cation complexing agent. Arsenazo III forms stable 1:1 complexes with Ca ²⁺, Mg ²⁺, Sr ²⁺, Ba ²⁺, K ⁺, and Na ⁺, and its binding affinity for Ca ²⁺ depends on pH, alkali metal cation concentration, and buffer parameters. Arsenazo III serves as a colorimetric indicator for micromolar ionized Ca ²⁺ in cells .

Benzocaine (hydrochloride) 1 Publications Verification	Sodium Channel Calcium Channel	Neurological Disease
Benzocaine hydrochloride is an orally active local anesthetic. Benzocaine hydrochloride non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine hydrochloride exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine hydrochloride induces methemoglobinemia in various experimental animals .

2,5-Di-tert-butylhydroquinone	Environmental Pollutants Calcium Channel COX Lipoxygenase	Inflammation/Immunology Cancer
2,5-Di-tert-butylhydroquinone (BHQ) (Compound 2), an indirect food additive, is a *Sarco/endoplasmic reticulum Ca ²⁺* ATPase (SERCA) inhibitor with an IC₅₀** of 400 nM. 2,5-Di-tert-butylhydroquinone disrupts the gating function of the residue Glu309 which prevents Ca ²⁺ from reaching their binding site. 2,5-Di-tert-butylhydroquinone regulates the activity of 5-lipoxygenase and COX-2 (IC₅₀: 1.8 and 14.1 μM for 5-LO and COX-2, respectively) .

Chelerythrine	Beta-lactamase PKC Bcl-2 Family Apoptosis Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy .

NR162	Ser/Thr Kinase	Neurological Disease
NR162 is a selective CASK (Ca ²⁺/calmodulin-dependent Ser/Thr kinase) inhibitor with an IC₅₀ of 80 nM and a Kd of 22 nM. NR162 shows about 50-fold selectivity for CASK than TYRO3. NR162 targets the unique GFG motif of CASK and has excellent shape complementarity to the CASK ATP binding pocket. NR162 can be used for the research of neurological diseases .

W-54011 5+ Cited Publications	Complement System Reactive Oxygen Species (ROS)	Inflammation/Immunology
W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of ¹²⁵I-labeled C5a to human neutrophils with a K_i value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca ²⁺ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC₅₀s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively .

ML604086 1 Publications Verification	CCR	Inflammation/Immunology Endocrinology
ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca ²⁺ concentrations .

CALP1 3 Publications Verification	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca ²⁺-binding site. CALP1 blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity .

Adenophostin A	Calcium Channel Chloride Channel	Others
Adenophostin A is an IP₃ receptor (inositol 1,4,5-trisphosphate receptors) modulator and *Ca ²⁺* releaser, with an IC₅₀ of 1.3 nM, an EC₅₀ of 1.4 nM, and a K_i of 0.18 nM in rats, and an IC₅₀ of 0.95 nM in humans. Adenophostin A activates IP₃ receptors, stimulates Ca ²⁺ release from intracellular stores and microsomes, inhibits the binding of [ ³H]IP₃ to plasma membrane receptors, and activates chloride channels. Adenophostin A resists phosphorylation and dephosphorylation by IP₃ metabolic enzymes to maintain its activity, and increases cytoplasmic [Ca ²⁺] levels via calcium mobilization from the endoplasmic reticulum of vascular smooth muscle cells. Adenophostin A is applicable to research related to hemorrhagic shock .

Verruculogen	Potassium Channel Bacterial	Infection Neurological Disease
Verruculogen is a tremorgenic mycotoxin and inhibitor of the M phase of the mammalian cell cycle. Verruculogen is produced by Penicillium and Aspergillus species. Verruculogen enhances the binding of ChTX to maxi-k channels with a K_1/2 value of 170 nM. Verruculogen inhibits the amplitude of Ca ²⁺-activated K ⁺ currents. Verruculogen induces severe tremors in infected animals .

SX-517	CXCR	Inflammation/Immunology
SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca ²⁺ flux (IC₅₀=38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC₅₀=60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model .

CALP3 2 Publications Verification	Calcium Channel	Neurological Disease Cancer
CALP3, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

*Calmodulin Binding* Peptide 1**	Calmodulin	Neurological Disease
Calmodulin Binding Peptide 1 is a high-affinity (pM) *CaM*-binding peptide derived from smooth muscle myosin light chain kinase (MLCK peptide). The interface of the complex formed by Calmodulin Binding Peptide 1 and Ca ²⁺-CaM can be specifically bound by small-molecule inhibitors, serving as a key target for selective regulation of smooth muscle contraction and development of anti-CaM drugs .

TMBIM6 antagonist-1	mTOR	Cancer
TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca ²⁺ .

CALP1 TFA 3 Publications Verification	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 TFA is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca ²⁺-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity .

PPZ2	Calcium Channel	Neurological Disease
PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects .

Calcium green-5N hexapotassium	Fluorescent Dye	Neurological Disease
Calcium green-5N hexapotassium is a cell-impermeant *Ca ²⁺*-sensitive fluorescent probe. Calcium green-5N hexapotassium shows enhancement in fluorescence intensity on binding Ca ²⁺, and can monitor free Ca ²⁺ in neurons .

CALP2 TFA	Calmodulin	Inflammation/Immunology
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .

Concanavalin A-AF488 Con A-AF488	Fluorescent Dye	Cancer
Concanavalin A-AF488 (Con A-AF488) is an AF488-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

BODIPY FL Thapsigargin	Calcium Channel	Others
BODIPY FL Thapsigargin is a potent green fluorescent dye. BODIPY FL Thapsigargin inhibits intracellular SERCA-type Ca2+ pumps present in the sarcoplasmic/endoplasmic reticulum. BODIPY FL Thapsigargin used for investigation of thapsigargin binding sites in live cells .

M6766	Endoplasmic Reticulum Oxidoreductase 1 (ERO1) Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease
M6766 is a selective endoplasmic reticulum oxidoreductase 1α (ERO1α) inhibitor with an IC₅₀ of 1.4 μM and a K_D of 1.1 μM. M6766 also inhibits ERO1β with an IC₅₀ of 7.2 μM. M6766 binds to the flavin adenine dinucleotide-binding pocket in ERO1α. M6766 inhibits granule secretion, αIIbβ3 integrin activation, Ca ²⁺ mobilization, and platelet aggregation. M6766 can be used for the research of neurological disease, such as ischemic stroke .

D-myo-Inositol 1,4,5-trisphosphate sodium salt	Biochemical Assay Reagents Calcium Channel Phospholipase	Neurological Disease Metabolic Disease
D-myo-inositol 1,4,5-trisphosphate sodium salt is a widely distributed intracellular second messenger. D-myo-inositol 1,4,5-trisphosphate sodium salt acts as a potent agonist of the Ins (1,4,5) P₃ receptor with an EC₅₀ of 0.12 μM and inhibits bovine PLC-δ1, with an IC₅₀ of 5.4 μM for binding and an IC₅₀ of 12.4 μM for hydrolysis. D-myo-inositol 1,4,5-trisphosphate sodium saltis metabolized into Ins (1,4) P₂ and Ins (1,3,4,5) P₄. D-myo-inositol 1,4,5-trisphosphate sodium salt mediates various cellular processes, including growth, development, fertilization, secretion, contraction and neuromodulation. D-myo-inositol 1,4,5-trisphosphate sodium salt inhibits PIP₂ hydrolysis and *Ca ²⁺-ATPase* activity. D-myo-inositol 1,4,5-trisphosphate sodium salt is used for cardiac preconditioning, exerts cardioprotective effects and mimics ischemic preconditioning. D-myo-inositol 1,4,5-trisphosphate sodium salt is applied in studies related to intracellular calcium and phosphoinositol signaling pathways .

L-Phenylalanine-15N,d8 (S)-2-Amino-3-phenylpropionic acid-¹⁵N,d₈	Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite	Metabolic Disease
L-Phenylalanine- ¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

INDO 1	Fluorescent Dye	Others
INDO 1 is a cell-impermeant fluorescent Ca ²⁺ indicator, binds specifically to Ca ²⁺ while emitting fluorescence, the maximum emission wavelength shifts from 485 nm before binding to 410 nm .

ZnAF-2	Biochemical Assay Reagents	Others
ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2 -specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2 . Little affinity for Ca2 , Mg2 , Na or K .

Fluo-3	Fluorescent Dye	Others
Fluo-3 is a cell-impermeable calcium ion (Ca ²⁺) indicator. Fluo-3 itself is not fluorescent, but it becomes fluorescent after binding to calcium ions (Ex/Em = 488/525 nm) .

N-myristoyl-RKRTLRRL	PKC	Cancer
N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. N-myristoyl-RKRTLRRL inhibits Ca ²⁺- and phosphatidylserine (PS)-dependent histone phosphorylation with IC₅₀ of 5 μM. histone phosphorylation with IC₅₀ of 80 μM .

Fluo-3 pentapotassium	Fluorescent Dye	Others
Fluo-3 pentapotassium is a cell-impermeable calcium ion (Ca ²⁺) indicator. Fluo-3 pentapotassium itself is not fluorescent, but it becomes fluorescent after binding to calcium ions (Ex/Em = 488/525 nm) .

Cav 3.2 inhibitor 3	Calcium Channel	Neurological Disease
Cav 3.2 inhibitor 3 (Compound 4) is a potent *Ca_v3.2 T-type Ca ²⁺* channel inhibitor with an IC₅₀** of 0.1534 μM, and has little binding affinity to D₂ receptors .

CJ-17493	Neurokinin Receptor	Neurological Disease
CJ-17493 is a neurokinin-1 (NK1) receptor antagonist, with a K_i of 0.2 nM. CJ-17493 shows moderate affinity for the verapamil-binding site of L-type Ca ²⁺ channels (IC₅₀ = 164 nM) and site 2 of sodium channels (IC₅₀ = 48 nM). CJ-17493 can be used for the study of neurological diseases .

Benzocaine (Standard) 1 Publications Verification	Reference Standards Sodium Channel Bacterial	Neurological Disease
Benzocaine (Standard) is the analytical standard of Benzocaine (HY-Y0258). This product is intended for research and analytical applications. Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

CXL 017	Calcium Channel	Cancer
CXL 017 is a sarco/endoplasmic reticulum Ca ²⁺-ATPase (SERCA) inhibitor. CXL 017 can inhibit the ATPase activity of SERCA by competing with ATP for binding. CXL 017 exhibits selective cytotoxicity against multidrug-resistant acute myeloid leukemia cells HL60/MX2. CXL 017 can be used in the research of tumors such as multidrug-resistant acute myeloid leukemia .

YM-344031	CCR	Inflammation/Immunology
YM-344031 is an orally active antagonist for CCR3. YM-344031 inhibits binding of Eotaxin-1 and RANTES to CCR3, with IC₅₀ of 3.0 and 16.3 nM. YM-344031 inhibits ligand-induced rise in intracellular Ca ^[2+] and the ligand-induced chemotaxis. YM-344031 inhibits eotaxin-1-induced changes in eosinophil morphology in macaques blood, and prevents allergic skin reactions in a mouse allergy model .

Rhod-5N	Fluorescent Dye	Others
Rhod-5N is a cell-impermeant calcium-binding fluorescent dye composed of a BAPTA chelating group and a rhodamine fluorophore. Rhod-5N is often added to MOPS buffer to complex and indicate cation content. The selectivity of Rhod-5N for Cd ²⁺ is higher than other interfering cations ((Na+, K+, Mg ²⁺, Ca ²⁺, Zn ²⁺) except Pb ²⁺), and the detection limit is 3.1 μg/L .

CaMKI(299-320) Calmodulin-Dependent Protein Kinase I (299-320) binding Domain	CaMK	Others
CaMKI (299-320) refers to a peptide consisting of residues 299-320 of Calcium/calmodulin-dependent protein kinase I (CaMKI). CaMKI (299-320), as a protein kinase, has a high affinity interaction with Ca ²⁺-CAM (K_d≤1 nM≤1 nM), which can phosphorylate specific substrate proteins, thereby regulating their activity. CaMKI (299-320) contains the CAM-binding domain and the self-inhibition domain, and CaMKI (299-320) can be used to study cell physiological processes, including cell proliferation, differentiation, and apoptosis .

L-Phenylalanine-d	Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite	Metabolic Disease Cancer
L-Phenylalanine-d is the deuterium labeled L-Phenylalanine (HY-N0215). L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca ²⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

YM-355179 fumarate	Endogenous Metabolite	Inflammation/Immunology
YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC₅₀ values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC₅₀ The values are 8.0 nM, 24 nM and 29 nM respectively .

AMD 3329 octahydrobromide	HIV CXCR	Infection
AMD 3329 octahydrobromide is a potent and selective anti-HIV-1 and HIV-2 compound with activity to inhibit viral replication. AMD 3329 blocks viral invasion by binding to the chemokine receptor CXCR4. AMD 3329 exhibits EC₅₀ values as low as 0.8 and 1.6 nM when inhibiting HIV-1 and HIV-2 replication, showing better antiviral efficacy than AMD3100. AMD 3329 significantly inhibits the binding of specific CXCR4 monoclonal antibodies and the Ca(2+) flux induced by SDF-1alpha. AMD 3329 is also able to effectively interfere with virus-induced syncytium formation, with an EC₅₀ value of 12 nM .

Cat. No.	Product Name

HY-L166

Ion Channel Compound Library

1,679 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1,679 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Type

HY-D1631

Calcium Green-5N AM	Fluorescent Dyes
Calcium Green-5N AM is a *Ca ²⁺*-sensitive fluorescent probe (K_d = 14 μM). Calcium Green-5N AM shows enhanced fluorescence intensity upon binding to Ca ²⁺, and it can monitor free Ca ²⁺ in neurons .

HY-D0202

Arsenazo III

Fluorescent Dyes

Arsenazo III is an azo derivative of chromotropic acid, a metal chrome dye, a chelating agent, and a cation complexing agent. Arsenazo III forms stable 1:1 complexes with Ca ²⁺, Mg ²⁺, Sr ²⁺, Ba ²⁺, K ⁺, and Na ⁺, and its binding affinity for Ca ²⁺ depends on pH, alkali metal cation concentration, and buffer parameters. Arsenazo III serves as a colorimetric indicator for micromolar ionized Ca ²⁺ in cells .

HY-D1631A

Calcium green-5N hexapotassium	Fluorescent Dyes
Calcium green-5N hexapotassium is a cell-impermeant *Ca ²⁺*-sensitive fluorescent probe. Calcium green-5N hexapotassium shows enhancement in fluorescence intensity on binding Ca ²⁺, and can monitor free Ca ²⁺ in neurons .

HY-D1608

BODIPY FL Thapsigargin	Fluorescent Dyes
BODIPY FL Thapsigargin is a potent green fluorescent dye. BODIPY FL Thapsigargin inhibits intracellular SERCA-type Ca2+ pumps present in the sarcoplasmic/endoplasmic reticulum. BODIPY FL Thapsigargin used for investigation of thapsigargin binding sites in live cells .

HY-D0121

INDO 1	Fluorescent Dyes
INDO 1 is a cell-impermeant fluorescent Ca ²⁺ indicator, binds specifically to Ca ²⁺ while emitting fluorescence, the maximum emission wavelength shifts from 485 nm before binding to 410 nm .

HY-126821

Fluo-3	Fluorescent Dyes
Fluo-3 is a cell-impermeable calcium ion (Ca ²⁺) indicator. Fluo-3 itself is not fluorescent, but it becomes fluorescent after binding to calcium ions (Ex/Em = 488/525 nm) .

HY-129547

Fluo-3 pentapotassium	Fluorescent Dyes
Fluo-3 pentapotassium is a cell-impermeable calcium ion (Ca ²⁺) indicator. Fluo-3 pentapotassium itself is not fluorescent, but it becomes fluorescent after binding to calcium ions (Ex/Em = 488/525 nm) .

HY-136894

Rhod-5N	Fluorescent Dyes
Rhod-5N is a cell-impermeant calcium-binding fluorescent dye composed of a BAPTA chelating group and a rhodamine fluorophore. Rhod-5N is often added to MOPS buffer to complex and indicate cation content. The selectivity of Rhod-5N for Cd ²⁺ is higher than other interfering cations ((Na+, K+, Mg ²⁺, Ca ²⁺, Zn ²⁺) except Pb ²⁺), and the detection limit is 3.1 μg/L .

HY-D0121A

INDO 1 pentapotassium	Fluorescent Dyes
INDO 1 pentapotassium is a cell-impermeant fluorescent Ca ²⁺ indicator, binds specifically to Ca ²⁺ while emitting fluorescence, the maximum emission wavelength shifts from 485 nm before binding to 410 nm .

HY-D0121B

INDO 1 pentasodium

Fluorescent Dyes

INDO 1 pentasodium is a cell-impermeant ratiometric, free calcium ion (Ca ²⁺) fluorescent indicator that can quantitatively monitor dynamic changes in intracellular free Ca ²⁺ concentrations. When unbound to Ca ²⁺ (free state), INDO 1 pentasodium exhibits a peak emission wavelength of 485 nm under UV excitation (350 nm). Upon binding to Ca ²⁺ (bound state), the emission peak shifts to 405 nm. INDO 1 pentasodium is highly photolabile and susceptible to photobleaching, and its emission spectrum may overlap with the autofluorescence of NADH .

HY-126821A

Fluo-3 pentaammonium	Fluorescent Dyes
Fluo-3 pentaammonium is a cell-impermeable calcium ion (Ca ²⁺) indicator. Fluo-3 pentaammonium itself is not fluorescent, but it becomes fluorescent after binding to calcium ions (Ex/Em = 488/525 nm) .

HY-D1755

Fluo-3FF AM	Fluorescent Dyes
Fluo-3FF AM is a low affinity (Kd = 42 μM) fluorescent Ca ²⁺ sensitive indicator (Abs/Em = 462 nm/526 nm). Fluo-3FF AM is Mg ²⁺ insensitive and relatively photostable. Fluo-3FF AM is an analog of Fluo-3FF AM. Fluo-3FF AM is essentially non-fluorescent, but exhibits a strong fluorescence enhancement upon entry into cells and binding to calcium.

HY-D3030

Concanavalin A-FITC	Fluorescent Dyes
Concanavalin A-FITC is a FITC (HY-66019)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins (Ex/Em = 488/525 nm) .

HY-D3031

Concanavalin A-TRITC	Fluorescent Dyes
Concanavalin A-TRITC is a TRITC (HY-D0791)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins (Ex/Em = 544/570 nm) .

Cat. No.	Product Name	Type

HY-NP009

α-Lactalbumin

Biochemical Assay Reagents

α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca ²⁺, Mg ²⁺, Mn ²⁺, Na ⁺, K ⁺ and Zn ²⁺ ions; among these, Ca ²⁺ binding enhances protein stability, while Zn ²⁺ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions .

HY-NP164

Concanavalin A-HRP Con A-HRP	Biochemical Assay Reagents
Concanavalin A-HRP (Con A-HRP) is a HRP-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164B

Concanavalin A-AF488 Con A-AF488	Biochemical Assay Reagents
Concanavalin A-AF488 (Con A-AF488) is an AF488-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-W795960

D-myo-Inositol 1,4,5-trisphosphate sodium salt

Biochemical Assay Reagents

D-myo-inositol 1,4,5-trisphosphate sodium salt is a widely distributed intracellular second messenger. D-myo-inositol 1,4,5-trisphosphate sodium salt acts as a potent agonist of the Ins (1,4,5) P₃ receptor with an EC₅₀ of 0.12 μM and inhibits bovine PLC-δ1, with an IC₅₀ of 5.4 μM for binding and an IC₅₀ of 12.4 μM for hydrolysis. D-myo-inositol 1,4,5-trisphosphate sodium saltis metabolized into Ins (1,4) P₂ and Ins (1,3,4,5) P₄. D-myo-inositol 1,4,5-trisphosphate sodium salt mediates various cellular processes, including growth, development, fertilization, secretion, contraction and neuromodulation. D-myo-inositol 1,4,5-trisphosphate sodium salt inhibits PIP₂ hydrolysis and Ca ²⁺-ATPase activity. D-myo-inositol 1,4,5-trisphosphate sodium salt is used for cardiac preconditioning, exerts cardioprotective effects and mimics ischemic preconditioning. D-myo-inositol 1,4,5-trisphosphate sodium salt is applied in studies related to intracellular calcium and phosphoinositol signaling pathways .

HY-D0157

ZnAF-2	Biochemical Assay Reagents
ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2 -specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2 . Little affinity for Ca2 , Mg2 , Na or K .

HY-W127795

Fluo-3 ammonium	Biochemical Assay Reagents
Fluo-3 ammonium is a cell-impermeable calcium ion (Ca ²⁺) indicator. Fluo-3 ammonium itself is not fluorescent, but it becomes fluorescent after binding to calcium ions (Ex/Em = 488/525 nm) .

HY-NP164K

Concanavalin A-AF568 Con A-AF568	Biochemical Assay Reagents
Concanavalin A-AF568 (Con A-AF546) is an AF568-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164M

Concanavalin A-AF680 Con A-AF680	Biochemical Assay Reagents
Concanavalin A-AF680 (Con A-AF680) is an AF680-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164D

Concanavalin A-AF405 Con A-AF405	Biochemical Assay Reagents
Concanavalin A-AF405 (Con A-AF405) is an AF405-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164I

Concanavalin A-AF546 Con A-AF546	Biochemical Assay Reagents
Concanavalin A-AF546 (Con A-AF546) is an AF546-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164E

Concanavalin A-AF430 Con A-AF430	Biochemical Assay Reagents
Concanavalin A-AF430 (Con A-AF430) is an AF430-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164O

Concanavalin A-Cy5 Con A-Cy5	Biochemical Assay Reagents
Concanavalin A-Cy5 (Con A-Cy5) is a Cy5 (HY-D0821)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins (Ex/Em = 630/670 nm) .

HY-NP164L

Concanavalin A-AF647 Con A-AF647	Biochemical Assay Reagents
Concanavalin A-AF647 (Con A-AF647) is an AF647-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164J

Concanavalin A-AF555 Con A-AF555	Biochemical Assay Reagents
Concanavalin A-AF555 (Con A-AF555) is an AF555-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164C

Concanavalin A-AF350 Con A-AF350	Biochemical Assay Reagents
Concanavalin A-AF350 (Con A-AF350) is an AF350-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164H

Concanavalin A-AF532 Con A-AF532	Biochemical Assay Reagents
Concanavalin A-AF532 (Con A-AF532) is an AF532-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164A

Concanavalin A-Cy5.5 Con A-Cy5.5	Biochemical Assay Reagents
Concanavalin A-Cy5.5 (Con A-Cy5.5) is a Cy5.5 (HY-D0924)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-NP164N

Concanavalin A-Cy3 Con A-Cy3	Biochemical Assay Reagents
Concanavalin A-Cy3 (Con A-Cy3) is a Cy5 (HY-D0822)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins (Ex/Em = 554/568 nm) .

Cat. No.	Product Name	Target	Research Area

HY-P1077

CALP1 3 Publications Verification	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca ²⁺-binding site. CALP1 blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity .

HY-P1075

CALP3 2 Publications Verification	Calcium Channel	Neurological Disease Cancer
CALP3, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-P1805

*Calmodulin Binding* Peptide 1**	Calmodulin	Neurological Disease
Calmodulin Binding Peptide 1 is a high-affinity (pM) *CaM*-binding peptide derived from smooth muscle myosin light chain kinase (MLCK peptide). The interface of the complex formed by Calmodulin Binding Peptide 1 and Ca ²⁺-CaM can be specifically bound by small-molecule inhibitors, serving as a key target for selective regulation of smooth muscle contraction and development of anti-CaM drugs .

HY-P1077A

CALP1 TFA 3 Publications Verification	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 TFA is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca ²⁺-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity .

HY-P1076A

CALP2 TFA	Calmodulin	Inflammation/Immunology
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .

HY-P5436

SK-MLCK M13	Peptides	Others
SK-MLCK M13 is a biological active peptide. (M-13 is a peptide that represents CAM-binding domain of Calmodulin (CaM) target proteins. CaM is an ubiquitous Ca2+ binding protein.)

HY-P5988

N-myristoyl-RKRTLRRL	PKC	Cancer
N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. N-myristoyl-RKRTLRRL inhibits Ca ²⁺- and phosphatidylserine (PS)-dependent histone phosphorylation with IC₅₀ of 5 μM. histone phosphorylation with IC₅₀ of 80 μM .

HY-P10316

CaMKI(299-320) Calmodulin-Dependent Protein Kinase I (299-320) binding Domain	CaMK	Others
CaMKI (299-320) refers to a peptide consisting of residues 299-320 of Calcium/calmodulin-dependent protein kinase I (CaMKI). CaMKI (299-320), as a protein kinase, has a high affinity interaction with Ca ²⁺-CAM (K_d≤1 nM≤1 nM), which can phosphorylate specific substrate proteins, thereby regulating their activity. CaMKI (299-320) contains the CAM-binding domain and the self-inhibition domain, and CaMKI (299-320) can be used to study cell physiological processes, including cell proliferation, differentiation, and apoptosis .

HY-P1075A

CALP3 TFA	Calcium Channel	Neurological Disease Cancer
CALP3 TFA, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 TFA can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-P1076

CALP2	Calmodulin	Inflammation/Immunology
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages .

HY-P2471

Neurogranin (48-76), mouse	Calmodulin	Neurological Disease
Neurogranin (48-76), mouse is a peptide corresponding to residues 48-76 of Neurogranin. Neurogranin, a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca ²⁺-CaM) pathway .

HY-P11700

AAPDARETA	MHC	Inflammation/Immunology
AAPDARETA is a mutated MHC-associated peptide with reduced binding affinity to H-2D ^b MHC molecules. AAPDARETA activates subsets of mouse main olfactory epithelium sensory neurons and induces Ca ²⁺ transients .

HY-P11825

APH-IN-1	Bacterial	Infection
APH-IN-1 is an Aminoglycoside phosphotransferase (APH) inhibitor with a K_d values of 63 nM against Escherichia coli APH(3′)-Ia. APH-IN-1 binds primarily to the ATP-binding pocket of APH in an ATP-competitive manner, with binding affinity enhanced by divalent metal ions (Mg ²⁺ and Ca ²⁺). APH-IN-1 can be used for the research of aminoglycoside-resistant bacterial infections .

Cat. No.	Product Name	Chemical Structure

HY-N0215S14

L-Phenylalanine-15N,d8

L-Phenylalanine- ¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

HY-178251S

L-Phenylalanine-d

L-Phenylalanine-d is the deuterium labeled L-Phenylalanine (HY-N0215). L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca ²⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

HY-Y0258S

Benzocaine-d4
Benzocaine-d₄ is the deuterium labeled Benzocaine (HY-Y0258). Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-Y0258S1

Benzocaine-(ethyl-d5)
Benzocaine-(ethyl-d₅) is the deuterium labeled Benzocaine (HY-Y0258). Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-166363S

Beraprost-d3

Beraprost-d₃ (TRK-100-d₃) is deuterium labeled (Rac)-Beraprost. (Rac)-Beraprost ((Rac)-ML 1229) is an orally active prostacyclin analog that inhibits the release of Ca ²⁺ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis .

HY-N2359S

Chelerythrine-d6 chloride

Chelerythrine-d₆ is the deuterium labeled Chelerythrine (HY-N2359). Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with an IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine triggers apoptosis and autophagy .

Host:	Mouse (3) Rabbit (1)
Reactivity:	Human (4) Rat (4) Mouse (3)
Application:	IHC-P (2) ICC/IF (4) IP (3) WB (4) ELISA (1)
Isotype:	IgG (1) IgG2b (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86510

	GRP78 BiP Antibody (YA6202) 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca; 2+; -binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	GRP78 BiP Antibody (YA6202) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GRP78 BiP.

HY-P80696

	GRP78 BiP Antibody (YA746) HSPA5; GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP	WB, ICC/IF, IP	Human, Mouse, Rat
	GRP78 BiP Antibody (YA746) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GRP78 BiP.

HY-P85741

	GRP78 BiP Antibody (YA5433) HSPA5; GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca; 2+; -binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP	WB, IHC-P, ICC/IF	Human, Rat
	GRP78 BiP Antibody (YA5433) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GRP78 BiP.

HY-P80696A

	GRP78 BiP Antibody (YA746)(PBS only) HSPA5; GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP	WB, ICC/IF, IP	Human, Mouse, Rat
	GRP78 BiP Antibody (YA746) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GRP78 BiP.

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Ca2 binding

Inhibitors & Agonists

Screening Libraries

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Biochemical Assay Reagents

Peptides

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