927871-76-9
927871-76-9
Chemical Structure
S107
- CAS No.: 927871-76-9
- Formula:C11H15NOS
- Molecular Weight:209.31
IUPAC Name: 7-methoxy-4-methyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine
InChIKey: BGVCEGVSQDOGSB-UHFFFAOYSA-N
SMILES: COC1=CC=C2C(CN(C)CCS2)=C1
Biological Activity: S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca2+ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold[1][2].
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S107 | 99.77% | S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca2+ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold. | ||||||||||||||||||||
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References
- [1]. Lehnart SE, et al. Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest. 2008 Jun;118(6):2230-45. [Content Brief]
- [2]. Sasaki K, et al. Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia. PLoS One. 2016 Oct 20;11(10):e0164795. [Content Brief]
Keywords
