23239-88-5
23239-88-5
Chemical Structure
Benzocaine (hydrochloride)
- CAS No.: 23239-88-5
- Formula:C9H12ClNO2
- Molecular Weight:201.65
IUPAC Name: ethyl 4-aminobenzoate hydrochloride
InChIKey: JAADDQHUJDUAKW-UHFFFAOYSA-N
SMILES: O=C(OCC)C1=CC=C(N)C=C1.[H]Cl
Biological Activity: Benzocaine hydrochloride is an orally active local anesthetic. Benzocaine hydrochloride non-competitively inhibits the binding of Ca-ATPase to Ca2+, with an IC50 of 47.1 mM. Benzocaine hydrochloride exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine hydrochloride induces methemoglobinemia in various experimental animals[1][2][3].
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Benzocaine (hydrochloride) | 99.83% | Benzocaine hydrochloride is an orally active local anesthetic. Benzocaine hydrochloride non-competitively inhibits the binding of Ca-ATPase to Ca2+, with an IC50 of 47.1 mM. Benzocaine hydrochloride exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine hydrochloride induces methemoglobinemia in various experimental animals. | ||||||||||||||||||||
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Benzocaine (hydrochloride) (Standard) | ≥98% | Benzocaine hydrochloride (Standard) is an analytical standard of Benzocaine hydrochloride (HY-Y0258A). This product is intended for research and analytical applications. Benzocaine hydrochloride is an orally active local anesthetic. Benzocaine hydrochloride non-competitively inhibits the binding of Ca-ATPase to Ca2+, with a IC50 of 47.1 mM. Benzocaine hydrochloride exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine hydrochloride induces methemoglobinemia in various experimental animals. | ||||||||||||||||||||
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References
- [1]. Wang GK, et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302. [Content Brief]
- [2]. Di Croce D, et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015;388(11):1163-1170. [Content Brief]
- [3]. Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993;54(8):1322-1326. [Content Brief]
