1. Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Calcium Channel
    Sodium Channel
    Potassium Channel
  3. Butamben

Butamben (Synonyms: Butyl 4-aminobenzoate)

Cat. No.: HY-B1430 Purity: ≥98.0%
Handling Instructions

Butamben (Butyl 4-aminobenzoate) has local narcotic effect. Butamben results in long-lasting relief from pain, without impairing motor function or other sensory functions.

For research use only. We do not sell to patients.

Butamben Chemical Structure

Butamben Chemical Structure

CAS No. : 94-25-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 g USD 60 In-stock
Estimated Time of Arrival: December 31
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50 g   Get quote  

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Description

Butamben (Butyl 4-aminobenzoate) has local narcotic effect. Butamben results in long-lasting relief from pain, without impairing motor function or other sensory functions[1][2].

IC50 & Target

Calcium Channel[2]
Sodium Channel[3]

In Vitro

Butamben (500 μM) blocks 90% of the control barium current, and this level is reached within 4 min in PC12 cells[2].
Butamben (100 μM; 2-10 min) increases the inactivation of the fast Na+ channels, but not of the slow Na+ channels[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Butamben (0.5-50 mM; the distal portion of the tail was immersed for 2 min) has an S-shape dose-dependent analgesic activity in the radiant heat tail-flick assay of mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

193.24

Formula

C₁₁H₁₅NO₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (517.49 mM)

H2O : 0.1 mg/mL (0.52 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1749 mL 25.8746 mL 51.7491 mL
5 mM 1.0350 mL 5.1749 mL 10.3498 mL
10 mM 0.5175 mL 2.5875 mL 5.1749 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Butamben
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HY-B1430
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