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DNA-binding activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (4) AP-1 (4) Apoptosis (15) Aryl Hydrocarbon Receptor (1) Bacterial (11) Bcl-2 Family (3) c-Myc (5) Calcium Channel (1) Carbonic Anhydrase (1) Caspase (1) CDK (2) COX (2) DNA Alkylator/Crosslinker (7) DNA/RNA Synthesis (19) Drug Derivative (2) EBV (2) Endogenous Metabolite (11) Endonuclease (1) Eukaryotic Initiation Factor (eIF) (1) Fluorescent Dye (1) Fungal (1) HCV (1) HCV Protease (1) HIF/HIF Prolyl-Hydroxylase (3) HIV (3) HSP (1) IFNAR (1) IGF-1R (2) Interleukin Related (4) Isotope-Labeled Compounds (8) JAK (1) JNK (1) MDM-2/p53 (6) Melatonin Receptor (2) MHC (1) MMP (4) mRNA (1) Necroptosis (1) NF-κB (14) Nucleoside Antimetabolite/Analog (1) PARP (1) PD-1/PD-L1 (1) PERK (1) Phosphatase (1) PIKfyve (1) Potassium Channel (2) PROTACs (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (4) Reference Standards (7) SARS-CoV (1) Ser/Thr Kinase (1) SF3B1 (1) Sodium Channel (1) STAT (8) STING (1) Survivin (1) Thrombin (1) TNF Receptor (1) Topoisomerase (5)
By Research Areas:	Cancer (70) Cardiovascular Disease (3) Endocrinology (2) Infection (15) Inflammation/Immunology (17) Metabolic Disease (9) Neurological Disease (6)
Oligonucleotides:	Transcription Factors (1) mRNA (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12684

CH-223191 Maximum Cited Publications 113 Publications Verification	Aryl Hydrocarbon Receptor	Cancer
CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC₅₀ of 0.03 μM .

HY-12270

T-5224 95+ Cited Publications	AP-1 MMP	Neurological Disease Inflammation/Immunology Cancer
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-W013049

Docosanoic acid Behenic acid	Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease Cancer
Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-N0629

Maslinic acid Maximum Cited Publications 17 Publications Verification Crategolic acid; 2α-Hydroxyoleanolic acid	NF-κB Bacterial HIV Endogenous Metabolite	Inflammation/Immunology Cancer
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-116248

Ro 41-5253 3 Publications Verification	RAR/RXR Apoptosis	Cancer
Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity .

HY-N0908

Ginsenoside Rg5 3 Publications Verification	IGF-1R NF-κB COX	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC₅₀ about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-128729

DNA2 inhibitor C5 5+ Cited Publications	DNA/RNA Synthesis	Cancer
DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC₅₀ of 20 μM. DNA2 inhibitor C5 inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. DNA2 inhibitor C5 can be used in breast cancer and colorectal cancer research .

HY-106101

Echinomycin 10+ Cited Publications Quinomycin A; NSC-13502	HIF/HIF Prolyl-Hydroxylase Antibiotic Bacterial	Cancer
Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC₅₀ of 29.4 pM .

HY-119970

Helenalin 5+ Cited Publications	NF-κB	Inflammation/Immunology Cancer
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-138280

DTHIB 5+ Cited Publications	HSP	Cancer
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a K_d of 160 nM for *DTHIB binding* to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1*. DTHIB has potently anticancer activities* and can be used for prostate cancer research .

HY-161252

PBD-monoamide	ADC Payload	Cancer
PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC). PBD-monoamide has DNA-binding activity and reduces cell viability .

HY-100609

4-P-PDOT 5+ Cited Publications	Melatonin Receptor	Neurological Disease
4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist. 4-P-PDOT is >300-fold more selective for MT2 than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity) .

HY-A0068

Aurothioglucose 2 Publications Verification Gold thioglucose	NF-κB HIV Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC₅₀ of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .

HY-U00447

PK11000	MDM-2/p53 DNA Alkylator/Crosslinker	Cancer
PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities .

HY-18371

TC-S 7009 1 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
TC-S 7009 is a potent and selective HIF-2α inhibitor with a K_d of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (K_d ? 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression .

HY-138113

Pyrrothiogatain 1 Publications Verification	DNA/RNA Synthesis Interleukin Related TNF Receptor Angiotensin-converting Enzyme (ACE) SARS-CoV	Infection Inflammation/Immunology Cancer
Pyrrothiogatain is a transcription factor GATA3 inhibitor with an IC₅₀ of 54.7 μM. Pyrrothiogatain inhibits the *DNA*-binding activity of GATA3 and inhibits the T helper 2 (Th2) cell differentiation and expression of Th2 cytokines. Pyrrothiogatain shows anti-infection effect by inhibiting ACE2 expression. Pyrrothiogatain can be used for the researches of inflammation, immunology, infection and cancer, such as colon cancer and SARS-CoV-2 infection .

HY-18061

Ochromycinone 3 Publications Verification (Rac)-STA-21	Antibiotic STAT Bacterial	Infection Cancer
Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity .

HY-N4058

Helichrysetin	Apoptosis	Cancer
Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity .

HY-128784

PK11007	MDM-2/p53 Reactive Oxygen Species (ROS)	Cancer
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .

HY-W035137

5,15-Diphenylporphyrin 5,15-DPP	STAT	Cancer
5,15-Diphenylporphyrin (5,15-DPP) is an inhibitor of the oncogenic transcription factor STAT3. 5,15-Diphenylporphyrin specifically binds to the SH2 domain of STAT3, blocking the pTyr-SH2 interaction, thereby inhibiting the dimerization, nuclear translocation and DNA binding activity of STAT3, and ultimately inhibiting the expression of cancer cell-related genes. 5,15-Diphenylporphyrin can be used in research fields related to the development of anticancer drugs[1][2].

HY-N6046

Kamebakaurin 1 Publications Verification	NF-κB Apoptosis Caspase HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology Cancer
Kamebakaurin is an orally active diterpenoid compound that can be isolated from Isodon excia (Maxin.). Kamebakaurin can inhibit NF-κB activation by directly targeting the DNA-binding activity of p50. Kamebakaurin can induce apoptosis and cell cycle arrest in tumor cells. Kamebakaurin has anti-inflammatory and anti-tumor activities .

HY-P99666

Interferon alfa-2b	IFNAR	Infection Cancer
Interferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Interferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .

HY-125471

VK-1727 1 Publications Verification	EBV	Infection Inflammation/Immunology Cancer
VK-1727 is a selective small molecule inhibitor of EBNA1. VK-1727 can reduce EBNA1 DNA binding activity. VK-1727 selectively blocks the proliferation and metabolic activity of EBV+ cells, instead of EBV- cells. VK-1727 is used in multiple sclerosis research .

HY-131236

EBNA1-IN-SC7	EBV	Cancer
EBNA1-IN-SC7 (compound SC7) is a selective Epstein-Barr nuclear antigen 1 (EBNA1) inhibitor that interferes with EBNA1-DNA binding activity with an IC₅₀ value of 23 μM. EBNA1-IN-SC7 is used in EBV (Epstein-Barr virus)-related cancer research .

HY-W013049S3

Docosanoic acid-d3 Behenic acid-d₃	Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease Cancer
Docosanoic acid-d₃ (Behenic acid-d₃) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-129056

Melagatran	Thrombin NF-κB AP-1	Cardiovascular Disease Neurological Disease
Melagatran is a reversible, selective, orally active direct inhibitor of thrombin with a K_i of 2 nM. Melagatran binds directly to the active site of thrombin, inhibiting thrombin-mediated conversion of fibrinogen to fibrin. Melagatran reduces the DNA binding activity of NF-κB and AP-1. Melagatran reduces fibrin deposition in organs, alleviates ischemic brain damage, and reduces the size of advanced atherosclerotic lesions. Melagatran can be used in the study of cardiovascular disease (coronary thrombosis, atherosclerosis) and ischemic brain damage .

HY-117669

VPC-14228	Androgen Receptor	Cancer
VPC-14228 is an inhibitor that selectively targets androgen receptor DNA binding domain (AR-DBD). VPC-14228 inhibits the interaction between AR and DNA, thereby blocking AR-mediated transcriptional activation. VPC-14228 does not rely on nuclear localization inhibition, but rather inhibits the activity of full-length AR and splice variant AR-V7 by interfering with AR binding to chromatin. And VPC-14228 has high selectivity for other nuclear receptors such as ER and PR. VPC-14228 can be used in the study of prostate cancer [2].

HY-153202

SLMP53-2	MDM-2/p53 Apoptosis	Cancer
SLMP53-2 is a mutant p53 reactivator. SLMP53-2 restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with the Hsp70, leading to the reestablishment of p53 transcriptional activity. SLMP53-2 can induce cell cycle arrest, apoptosis and endoplasmic reticulum (ER) stress. SLMP53-2 exhibits antitumor activity .

HY-N8146

Bruceantinol	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK	Infection Cancer
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .

HY-118581

Coralyne chloride 1 Publications Verification	Topoisomerase	Cancer
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes .

HY-P990021

Calpurbatug TRL1068	Bacterial	Others
Calpurbatug is an immunoglobulin G1 antibody. Calpurbatug has activity with anti-bacterial DNA-binding protein DNABII family and anti-human monoclonal TRL1068 γ1-chain .

HY-126979

Mycro2	c-Myc	Cancer
Mycro2 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC₅₀ value of 23 μM for the inhibition of Myc/Max DNA binding activity. Mycro2 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .

HY-172767

STAT3-D11-PROTAC-VHL	PROTACs STAT Apoptosis	Cancer
STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting Signal Transducer and Activator of Transcription 3 (STAT3). STAT3-D11-PROTAC-VHL exhibits anti-tumor activity with IC₅₀ values of 1335 nM and 1973 nM against HeLa and MCF-7 cells, respectively. STAT3-D11-PROTAC-VHL binds to the DNA-binding domain of STAT3 and recruits the E3 ligase VHL to form a ternary complex, leading to the ubiquitination of STAT3 and subsequent degradation by the proteasome. STAT3-D11-PROTAC-VHL also inhibits tumor cell growth, induces cell cycle arrest and apoptosis, and suppresses tumor immune evasion .

HY-139038

TDRL-X80	DNA/RNA Synthesis	Cancer
TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC₅₀s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC₅₀s of 21, 39, and 28 in ELISA Analysis .

HY-W181026

KLF10-IN-1	Fluorescent Dye	Inflammation/Immunology
KLF10-IN-1 (#48-15) is a KLF10 inhibitor with an IC₅₀ value of 40 μM for KLF10 reporter gene. KLF10-IN-1 can inhibit KLF10-DNA binding and transcriptional activity, block the conversion of CD4+CD25 T cells to CD4+CD25+T regulatory cells, and inhibit the expression of KLF10 target genes. KLF10-IN-1 can be used as a useful mechanistic probe to study KLF10-mediated effects and T regulatory cell biology .

HY-W013049S1

Docosanoic acid-d43 Behenic acid-d₄₃	Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease Cancer
Docosanoic acid-d₄₃ (Behenic acid-d₄₃) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049S4

Docosanoic acid-d4-1 Behenic acid-d₄-1	Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease Cancer
Docosanoic acid-d₄-1 (Behenic acid-d₄-1) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-132276

PtdIns-(3,4,5)-P3-biotin sodium	Phosphatase	Others
PtdIns-(3,4,5)-P3-biotin sodium is a Biotin-labeled PtdIns-(3,4,5)-P3 (PI(3,4,5)P3). PI(3,4,5)P3 is a substrate of nuclear phosphatidylinositol 5-phosphatase (PIP5Pase). PI(3,4,5)P3 binds to the N-terminus of RAP1 (repressor activator protein 1) and controls its DNA binding activity .

HY-160129

Centanamycin ML-970; AS-I-145; NSC 716970	Nucleoside Antimetabolite/Analog	Cancer
Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI₅₀ of 34 nM in NCI-60 cell line screening .

HY-N0629R

Maslinic acid (Standard) Crategolic acid (Standard); 2α-Hydroxyoleanolic acid (Standard)	Reference Standards NF-κB Bacterial HIV Endogenous Metabolite	Inflammation/Immunology Cancer
Maslinic acid (Standard) is the analytical standard of Maslinic acid. This product is intended for research and analytical applications. Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-130073

Amorfrutin A	NF-κB Apoptosis	Cancer
Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis .

HY-128729R

DNA2 inhibitor C5 (Standard)	Reference Standards DNA/RNA Synthesis	Cancer
DNA2 inhibitor C5 (Standard) is the analytical standard of DNA2 inhibitor C5 (HY-128729). This product is intended for research and analytical applications. DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC₅₀ of 20 μM. DNA2 inhibitor C5 inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. DNA2 inhibitor C5 can be used in breast cancer and colorectal cancer research.

HY-123876

AS2677131	PIKfyve Interleukin Related MHC	Inflammation/Immunology
AS2677131 is a potent and orally active PIKfyve inhibitor. AS2677131 inhibits f IL-12p40, IL-6 and IL-1β through a PIKfyve-c-Rel pathway. AS2677131 selectively inhibits DNA-binding activity of c-Rel to IL-12p40 and IL-1β promoter. AS2677131 inhibits MHC class II expression on B cells. AS2677131 can be used for the researches of inflammation and immunology, such as arthritis .

HY-125636

Mycro1	c-Myc	Cancer
Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC₅₀ value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .

HY-W013049S6

Docosanoic acid-13C4 Behenic acid-¹³C₄	Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Docosanoic acid- ¹³C₄ (Behenic acid- ¹³C₄) is the ¹³C-labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in vivo .

HY-121352

Kibdelone C	Drug Derivative	Cancer
Kibdelone C is a hexacyclic tetrahydroxanthone natural product and anticancer agent with sub-nanomolar GI₅₀ activity against human SR leukemia and SN12C renal carcinoma cell lines. Kibdelone C disrupts the actin cytoskeleton in human cancer cells, leading to cell contraction and actin stress fiber formation, without direct actin binding, actin polymerization effects, topoisomerase I/II inhibition, or DNA binding. Kibdelone C can be used for the research of leukemia, and renal cell carcinoma .

HY-N0908R

Ginsenoside Rg5 (Standard)	Reference Standards IGF-1R NF-κB COX	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ginsenoside Rg5 (Standard) is the analytical standard of Ginsenoside Rg5. This product is intended for research and analytical applications. Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC50 about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-12270R

T-5224 (Standard)	AP-1 MMP	Others
T-5224 (Standard) is the analytical standard of T-5224. This product is intended for research and analytical applications. T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-106091B

Losoxantrone hydrochloride CI 941 hydrochloride; DUP 94 hydrochloride	DNA Alkylator/Crosslinker	Cancer
Losoxantrone hydrochloride (CI 941 hydrochloride) is a *DNA-binding* agent. Losoxantrone hydrochloride has broad-spectrum antitumour activity. Losoxantrone hydrochloride induces dose-dependent leukopenia .

HY-139118

NSC308848	c-Myc Apoptosis	Cancer
NSC308848 is a potent apoptosis inducer in a Myc-dependent manner. NSC308848 inhibits Myc transactivation and interferes with the DNA-binding activity of Myc family proteins .

Cat. No.	Product Name	Target	Research Area

HY-A0299

H-Gly-Pro-Hyp-OH Tripeptide 29	Peptides	Inflammation/Immunology
H-Gly-Pro-Hyp-OH is a collagen-derived peptide and also a dipeptidyl peptidase-4 inhibitor.\nH-Gly-Pro-Hyp-OH inhibits the activity of dipeptidyl peptidase-4 in vitro. H-Gly-Pro-Hyp-OH binds to the DNA-binding site of the JUN/FOS complex, blocks the formation of the DNA-JUN/FOS complex, and inhibits transcriptional activity. H-Gly-Pro-Hyp-OH is applicable to research related to skin photoaging, UVB-induced skin aging/photoaging, and thrombosis .

HY-P11600

SGNLTKYWKKIWKPGIKKWIK	Bacterial Reactive Oxygen Species (ROS) Interleukin Related DNA/RNA Synthesis	Infection
SGNLTKYWKKIWKPGIKKWIK is a thymidylate kinase (TMK)-targeting antimicrobial peptide with a K_D value of 4.721 μM. SGNLTKYWKKIWKPGIKKWIK exerts antimicrobial effects through multiple mechanisms, including membrane disruption, induction of ROS, and *DNA* binding. SGNLTKYWKKIWKPGIKKWIK shows remarkable activity against Gram-negative bacteria, possesses good biocompatibility, and rarely induces drug resistance. SGNLTKYWKKIWKPGIKKWIK can be used for research on Gram-negative bacterial infections .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99666

Interferon alfa-2b	IFNAR	Infection Cancer
Interferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Interferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .

HY-P990021

Calpurbatug TRL1068	Bacterial	Others
Calpurbatug is an immunoglobulin G1 antibody. Calpurbatug has activity with anti-bacterial DNA-binding protein DNABII family and anti-human monoclonal TRL1068 γ1-chain .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013049

Docosanoic acid Behenic acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite DNA/RNA Synthesis
Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-N0629

Maslinic acid Maximum Cited Publications 17 Publications Verification Crategolic acid; 2α-Hydroxyoleanolic acid	Triterpenes other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	NF-κB Bacterial HIV Endogenous Metabolite
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-N0908

Ginsenoside Rg5 3 Publications Verification	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Endocrinology Source Classification	IGF-1R NF-κB COX
Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC₅₀ about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-119970

Helenalin 5+ Cited Publications	other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-18061

Ochromycinone 3 Publications Verification (Rac)-STA-21	Infection Quinones Monophenols Microorganisms Classification of Application Fields Anthraquinones Phenols Disease Research Fields Source Classification	Antibiotic STAT Bacterial
Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity .

HY-N4058

Helichrysetin	Chalcones Flavonoids Classification of Application Fields Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Source Classification Zingiberaceae Cancer	Apoptosis
Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity .

HY-N6046

Kamebakaurin 1 Publications Verification	Classification of Application Fields Terpenoids Labiatae Hymenaea verrucosa Gaertn. Diterpenoids Plants Inflammation/Immunology Disease Research Fields Cancer	NF-κB Apoptosis Caspase HIF/HIF Prolyl-Hydroxylase
Kamebakaurin is an orally active diterpenoid compound that can be isolated from Isodon excia (Maxin.). Kamebakaurin can inhibit NF-κB activation by directly targeting the DNA-binding activity of p50. Kamebakaurin can induce apoptosis and cell cycle arrest in tumor cells. Kamebakaurin has anti-inflammatory and anti-tumor activities .

HY-N8146

Bruceantinol	Infection Triterpenes Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Source Classification Cancer	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .

HY-N0629R

Maslinic acid (Standard) Crategolic acid (Standard); 2α-Hydroxyoleanolic acid (Standard)	Triterpenes Structural Classification other families Terpenoids Plants Source Classification	Reference Standards NF-κB Bacterial HIV Endogenous Metabolite
Maslinic acid (Standard) is the analytical standard of Maslinic acid. This product is intended for research and analytical applications. Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-130073

Amorfrutin A	Simple Phenylpropanols Leguminosae Amorpha fruticosaL. Phenylpropanoids Plants Source Classification	NF-κB Apoptosis
Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis .

HY-N0908R

Ginsenoside Rg5 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Araliaceae Source Classification	Reference Standards IGF-1R NF-κB COX
Ginsenoside Rg5 (Standard) is the analytical standard of Ginsenoside Rg5. This product is intended for research and analytical applications. Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC50 about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-N11669

Demycarosyl-3D-β-D-digitoxosylmithramycin SK	Natural Products Microorganisms Source Classification	DNA/RNA Synthesis
Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins .

HY-125633

Kapurimycin A3	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Kapurimycin A3 is an antitumor and antibacterial antibiotic. Kapurimycin A3 has DNA binding and breakage activity. Kapurimycin A3 can be isolated from Streptomyces .

HY-W013049R

Docosanoic acid (Standard) Behenic acid (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Reference Standards Endogenous Metabolite DNA/RNA Synthesis
Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-18061R

Ochromycinone (Standard) (Rac)-STA-21 (Standard)	Quinones Monophenols Microorganisms Anthraquinones Phenols Source Classification	Antibiotic Reference Standards STAT Bacterial
Ochromycinone (Standard) ((Rac)-STA-21 (Standard)) is the analytical standard of Ochromycinone (HY-18061). This product is intended for research and analytical applications. Ochromycinone is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity.

HY-N4058R

Helichrysetin (Standard)	Structural Classification Chalcones Flavonoids Phenols Polyphenols Alpinia officinarum Hance Plants Source Classification Zingiberaceae	Reference Standards Apoptosis
Helichrysetin (Standard) is the analytical standard of Helichrysetin. This product is intended for research and analytical applications. Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity .

HY-N11739

Helenalin isobutyrate	Structural Classification Terpenoids Sesquiterpenes Euchresta horsfieldii (Lesch.) J. Benn. Plants Compositae Source Classification	NF-κB
Helenalin isobutyrate is an NF-κB (p65 subunit) inhibitor with anti-inflammatory activity. Helenalin isobutyrate irreversibly alkylates cysteine sulfhydryl groups in the p65 subunit to inhibit NF-κB complex DNA binding activity .

HY-N19791

6-Methoxymellein	Structural Classification Monophenols Coumarins Phenols Phenylpropanoids Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants Source Classification	NF-κB Fungal Interleukin Related
6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44 ⁺/CD24 ⁻ breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot .

Cat. No.	Product Name	Chemical Structure

HY-W013049S3

Docosanoic acid-d3
Docosanoic acid-d₃ (Behenic acid-d₃) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049S1

Docosanoic acid-d43
Docosanoic acid-d₄₃ (Behenic acid-d₄₃) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049S4

Docosanoic acid-d4-1
Docosanoic acid-d₄-1 (Behenic acid-d₄-1) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049S6

Docosanoic acid-13C4
Docosanoic acid- ¹³C₄ (Behenic acid- ¹³C₄) is the ¹³C-labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in vivo .

HY-W013049S

Docosanoic acid-d4
Docosanoic acid-d₄ (Behenic acid-₄) is deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049S2

Docosanoic acid-d2
Docosanoic acid-d₂ (Behenic acid-d₂) is deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049S5

Docosanoic acid-d4-2
Docosanoic acid-d₄-2 (Behenic acid-d₄-2) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-12270S

T-5224-d8
T-5224-d₈ is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Cat. No.	Product Name		Classification

HY-174583

Human MEF2C mRNA		mRNA Transcription Factors
Human MEF2C mRNA encodes the human myocyte enhancer factor 2C (MEF2C) protein, a member of the MADS box transcription enhancer factor 2 (MEF2) family. MEF2C has both trans-activating and DNA binding activities and may play a role in maintaining the differentiated state of muscle cells.

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