5 Results for "

ET-18-OCH3

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "ET-18-OCH3" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-108610A
CAS No.: 70641-51-9
Purity:  ≥99.0%
Synonyms: ET-18-OCH3
Edelfosine (ET-18-OCH3) is an orally active lipid raft modulator and apoptosis inducer that alters membrane fluidity and preferentially inserts into tumor cell membranes. Edelfosine recruits death receptor ligands (FasL/CD95L, TRAIL) and Bid to lipid rafts to form death-inducing signaling complexes, thereby initiating mitochondria-dependent apoptosis and inducing cytochrome c release. Edelfosine also exerts anti-inflammatory effects, promotes L-Selectin shedding, and causes no gastrointestinal or organ toxicity. In addition, Edelfosine inhibits nucleic acid and protein synthesis in Leishmania donovani and exhibits antiproliferative activity. Edelfosine can be used in research on multiple myeloma, inflammatory bowel diseases (such as ulcerative colitis and Crohn's disease), and visceral leishmaniasis .
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Cat. No.: HY-108610
CAS No.: 77286-66-9
Purity:  99.00%
Synonyms: (R)-ET-18-OCH3
Target:  

HIV

Research Areas:  

Infection Cancer

(R)-Edelfosine ((R)-ET-18-OCH3) is a ether lipid analog with anti-HIV and antineoplastic activity .
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Cat. No.: HY-108610C
CAS No.: 83542-43-2
Synonyms: (S)-ET-18-OCH3
Target:  

Apoptosis

Research Areas:  

Cancer

(S)-Edelfosine ((S)-ET-18-OCH3) is the (S)-enantiomer of Edelfosine (ET-18-OCH3) (HY-108610C). Edelfosine is a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 Death receptor .
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Cat. No.: HY-108610R
CAS No.: 77286-66-9
Synonyms: (R)-ET-18-OCH3 (Standard)
Target:  

Reference Standards HIV

Research Areas:  

Infection Cancer

(R)-Edelfosine (Standard) is the analytical standard of (R)-Edelfosine (HY-108610). This product is intended for research and analytical applications. (R)-Edelfosine ((R)-ET-18-OCH3) is a ether lipid analog with anti-HIV and antineoplastic activity .
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Cat. No.: HY-P11860
Target:  

nAChR

Research Areas:  

Neurological Disease

WrFr-OCH3 is a competitive nAChR inhibitor, with IC50 values of 291.9 nM, 25.3 nM, 477.5 nM and 36.5 nM against hα1β1εδ nAChR, hα9α10 nAChR, hα7 nAChR and hα9 nAChR, respectively. WrFr-OCH3 exhibits analgesic and muscle relaxant effects, reduces forelimb grip strength in rats, and alleviates Oxaliplatin (HY-17371)-induced cold allodynia in rats. WrFr-OCH3 can be used in studies related to cold allodynia .
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