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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
EphB4 tyrosine kinase
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "EphB4 tyrosine kinase" in MCE Product Catalog:
Cat. No.: HY-15268
CAS No.: 1092787-12-6
PP487 is a selective dual inhibitor of Tyrosine kinase/PI3-K, with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used in cancer research .
Cat. No.: HY-10654
CAS No.: 1192216-03-7
Target:
Research Areas:
EphB4-IN-2 is a tyrosine kinase inhibitor targeting the Eph family and Src family. EphB4-IN-2 binds to the ATP-binding site of the kinase domain of EphB4, and exhibits high affinity for tyrosine kinases with threonine as the gatekeeper residue, such as Abl, Lck and Src. EphB4-IN-2 can be used in research related to tumor-associated angiogenesis .
Cat. No.: HY-185227
CAS No.: 1394837-94-5
Target:
Research Areas:
EphB4-IN-1 is a selective EphB4 tyrosine kinase inhibitor with IC50 values of 0.16-0.30 μM. EphB4-IN-1 binds to the ATP binding site of EphB4 in a DFG-in conformation, forming four stable intermolecular hydrogen bonds. EphB4-IN-1 also inhibits Src, Abl1, Lck, and EGFR kinases. EphB4-IN-1 inhibits EphB4 autophosphorylation. EphB4-IN-1 can be used for the research of cancer, such as non small cell lung cancer .
Cat. No.: HY-171217
CAS No.: 867330-68-5
Target:
Research Areas:
TG-100435 is a multitargeted, orally active protein tyrosine kinase inhibitor, with Ki of 13 to 64 nM for Src, Lyn, Abl, Yes, Lck, and EphB4. TG-100435 plays an important role in cancer research .
Cat. No.: HY-P73004
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EphB4; tyrosine-Protein kinase Receptor HTK; Prev. HTK; Ephrin Receptor EphB4; Hepatoma Transmembrane kinase; CMAVM2; Ephrin Type-B Receptor 4; LMPHM7; Tyro11; TYRO11; tyrosine-Protein kinase TYRO11; EphB4; MYK1; HFASD; EPH Receptor B4; Receptor Protein-T
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73005
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EphB4; tyrosine-Protein kinase Receptor HTK; Prev. HTK; Ephrin Receptor EphB4; Hepatoma Transmembrane kinase; CMAVM2; Ephrin Type-B Receptor 4; LMPHM7; Tyro11; TYRO11; tyrosine-Protein kinase TYRO11; EphB4; MYK1; HFASD; EPH Receptor B4; Receptor Protein-T
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74171
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EphB4; tyrosine-Protein kinase Receptor HTK; Prev. HTK; Ephrin Receptor EphB4; Hepatoma Transmembrane kinase; CMAVM2; Ephrin Type-B Receptor 4; LMPHM7; Tyro11; TYRO11; tyrosine-Protein kinase TYRO11; EphB4; MYK1; HFASD; EPH Receptor B4; Receptor Protein-T
Species:
Human
Source:
HEK293
Cat. No.: HY-P77646
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: EphB4; tyrosine-Protein kinase Receptor HTK; Prev. HTK; Ephrin Receptor EphB4; Hepatoma Transmembrane kinase; CMAVM2; Ephrin Type-B Receptor 4; LMPHM7; Tyro11; TYRO11; tyrosine-Protein kinase TYRO11; EphB4; MYK1; HFASD; EPH Receptor B4; Receptor Protein-T
Species:
Human
Source:
HEK293
Cat. No.: HY-P73002
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EphB4; tyrosine-Protein kinase Receptor HTK; Prev. HTK; Ephrin Receptor EphB4; Hepatoma Transmembrane kinase; CMAVM2; Ephrin Type-B Receptor 4; LMPHM7; Tyro11; TYRO11; tyrosine-Protein kinase TYRO11; EphB4; MYK1; HFASD; EPH Receptor B4; Receptor Protein-T
Species:
Human
Source:
HEK293
Cat. No.: HY-P73003
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EphB4; tyrosine-Protein kinase Receptor HTK; Prev. HTK; Ephrin Receptor EphB4; Hepatoma Transmembrane kinase; CMAVM2; Ephrin Type-B Receptor 4; LMPHM7; Tyro11; TYRO11; tyrosine-Protein kinase TYRO11; EphB4; MYK1; HFASD; EPH Receptor B4; Receptor Protein-T
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P77545
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EphB4; tyrosine-Protein kinase Receptor HTK; Prev. HTK; Ephrin Receptor EphB4; Hepatoma Transmembrane kinase; CMAVM2; Ephrin Type-B Receptor 4; LMPHM7; Tyro11; TYRO11; tyrosine-Protein kinase TYRO11; EphB4; MYK1; HFASD; EPH Receptor B4; Receptor Protein-T
Species:
Human
Source:
HEK293
Cat. No.: HY-179572
Target:
Research Areas:
STA-013 is a EphB tyrosine kinase inhibitor. STA-013 shows promising potency against EphB1 (IC50 = 0.69 µM), EphB2 (IC50 = 1.73 µM), and EphB4 (IC50 = 1.02 µM) tyrosine kinases. STA-013 results a inhibition of the EphB phosphorylated signal, coupled with increased p-AKT/AKT signaling, to suggest insulin signaling activation. STA-013 inhibits EphB tyrosine kinase by enhancing insulin receptor beta (IRβ) signaling, and decreasing TGF-β levels in the heart. STA-013 can be used for the study of type 2 diabetes and cardiac complications (diabetic cardiomyopathy) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
