1 Result for "

FMAB2

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "FMAB2" in MCE Product Catalog:

Cat. No.: HY-P990957
CAS No.: 2764727-44-6
Synonyms: BCA-101; FMAB2

Target:  

EGFR TGF-beta/Smad

Research Areas:  

Inflammation/Immunology Cancer

Ficerafusp alfa (BCA-101) is a bispecific antibody targeting EGFR and TGFβ, with a Kd of 2.58 nM against EGFR and a Kd of 61.3 nM against TGFβ1. Ficerafusp alfa binds to EGFR, inhibits EGFR phosphorylation, blocks EGF-dependent cell proliferation, and mediates antibody-dependent cellular cytotoxicity against EGFR-positive tumor cells. Ficerafusp alfa sequesters TGFβ via its TGFβRII ECD domain, neutralizes the activity of TGFβ and TGFβ1, and blocks TGFβ-dependent processes, including epithelial-mesenchymal transition, cell invasion, and differentiation of inducible regulatory T cells. Ficerafusp alfa is applicable to research related to head and neck squamous cell carcinoma, advanced solid tumors, squamous non-small cell lung cancer, anal squamous cell carcinoma, colorectal cancer, and pancreatic cancer [2] .
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