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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Frizzled 4 (FZD4)
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Frizzled 4 (FZD4)" in MCE Product Catalog:
2
2 Cited Publications
FzM1.8 is a Wnt/β-catenin signaling pathway agonist and an allosteric agonist of Frizzled 4 (FZD4), with a pEC50 of 6.4 for FZD4 . FzM1.8 stabilizes a conformation with increased affinity for heterotrimeric G proteins, promoting Gβγ release and subsequent PI3K activation. FzM1.8 activates the AKT pathway downstream of FZD4. FzM1.8 does not affect FZD4 maturation or plasma membrane localization and does not induce FZD4 endocytosis. FzM1.8 upregulates the WNT-responsive genes C-myc and Cyclin D1, while leaving lgr5 expression unchanged. FzM1.8 can be used for colon cancer research .
Cat. No.: HY-P74140
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FZD4; Frizzled Homolog 4 (Drosophila); Prev. EVR1; Exudative Vitreoretinopathy 1; CD344; WNT Receptor Frizzled-4; Frizzled 4, Seven Transmembrane Spanning Receptor; Frizzled Homolog 4; Frizzled Family Receptor 4; CD344 Antigen; Frizzled-4; FZD4S; Fz-4; FE
Species:
Human
Source:
HEK293
Cat. No.: HY-P74141
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FZD4; Frizzled Homolog 4 (Drosophila); Prev. EVR1; Exudative Vitreoretinopathy 1; CD344; WNT Receptor Frizzled-4; Frizzled 4, Seven Transmembrane Spanning Receptor; Frizzled Homolog 4; Frizzled Family Receptor 4; CD344 Antigen; Frizzled-4; FZD4S; Fz-4; FE
Species:
Human
Source:
HEK293
Cat. No.: HY-P74142
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FZD4; Frizzled Homolog 4 (Drosophila); Prev. EVR1; Exudative Vitreoretinopathy 1; CD344; WNT Receptor Frizzled-4; Frizzled 4, Seven Transmembrane Spanning Receptor; Frizzled Homolog 4; Frizzled Family Receptor 4; CD344 Antigen; Frizzled-4; FZD4S; Fz-4; FE
Species:
Rat
Source:
HEK293
Cat. No.: HY-P74143
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FZD4; Frizzled Homolog 4 (Drosophila); Prev. EVR1; Exudative Vitreoretinopathy 1; CD344; WNT Receptor Frizzled-4; Frizzled 4, Seven Transmembrane Spanning Receptor; Frizzled Homolog 4; Frizzled Family Receptor 4; CD344 Antigen; Frizzled-4; FZD4S; Fz-4; FE
Species:
Rat
Source:
HEK293
Cat. No.: HY-P87422A
Synonyms: CD344, Frizzled-4, Fz-4, hFz4, FzE4, FZD4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
