Search Result
Results for "
Glucuronide
" in MedChemExpress (MCE) Product Catalog:
46
Biochemical Assay Reagents
90
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W040047
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Endogenous Metabolite
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Metabolic Disease
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Pregnanediol 3-glucuronide is the main terminal metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is the metabolite of Progesterone produced in the liver through hydroxylation and glucuronidation, with high hydrophilicity and easy excretion through urine. A decrease in the level of Pregnanediol 3-glucuronide is associated with an increased risk of thyroid cancer, while an increase is associated with the state of pregnancy. Pregnanediol 3-glucuronide is of great significance in the monitoring of female reproductive health, pregnancy assessment, and the diagnosis of endocrine diseases .
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- HY-W008917
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- HY-N1454
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Apigenin 7-O-Glucuronide
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MMP
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Cancer
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Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.
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- HY-137522
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3'-Azido-3'-deoxythymidine β-D-Glucuronide sodium
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Drug Metabolite
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Others
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Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .
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- HY-113093
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Endogenous Metabolite
Toll-like Receptor (TLR)
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Neurological Disease
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Ethyl glucuronide is an endogenous metabolite. Ethyl glucuronide is the metabolite of ethanol. Ethyl glucuronide is a biomarker for ethanol exposure that accumulates in hair and reflects the alcohol intake over a time period. Ethyl glucuronide is the agonist for TLR4 .
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- HY-N7176
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Kaempferol-3-Glucuronide; Kaempferol-3-O-Glucuronide
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Interleukin Related
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Metabolic Disease
Inflammation/Immunology
Cancer
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Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide) is a metabolite of kaempferol that can be taken orally and has anti-inflammatory properties. Kaempferol 3-O-β-D-glucuronide can activate AKT/GSK3β phosphorylation and improve glucose metabolism .
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- HY-113157
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Drug Metabolite
Endogenous Metabolite
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Endocrinology
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Estrone 3-glucuronide is a dominant urinary metabolite of Estradiol (HY-B0141) and urinary marker for female fertile window prediction. Estrone 3-glucuronide can be used in combination with luteinizing hormone in ovulation prediction kits [2].
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- HY-137301
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Drug Metabolite
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Cancer
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Mycophenolic acid glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic acid glucuronide shows anti-tumor activity and can be used in adenocarcinoma research .
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- HY-135391
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Ezetimibe Glucuronide; Ezetimibe β-D-Glucuronide
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Drug Metabolite
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Metabolic Disease
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Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity . Ezetimibe is a potent cholesterol absorption inhibitor .
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- HY-113093S
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- HY-135582
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Estrogen Receptor/ERR
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Endocrinology
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Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
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- HY-N7755
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Endogenous Metabolite
ATP-binding cassette (ABC) transporters
OAT
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Others
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Estradiol 3-glucuronide sodium is an estrogen metabolite, which is a glucuronide conjugate formed by the catalysis of uridine diphosphate glucuronosyltransferase in tissues such as the liver from Estradiol (HY-B0141). Estradiol 3-glucuronide sodium is a potent substrate of Mrp2, with an S50 of 55.7 μM. Estradiol 3-glucuronide sodium achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and OATP2B1, as well as apical efflux via MRP2 and BCRP .
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- HY-137967
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Genistein 7-O-Glucuronide
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Drug Metabolite
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Metabolic Disease
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Genistein 7-β-D-Glucuronide (Genistein 7-O-glucuronide) is the primary phase II metabolite of Genistein (HY-14596) in human and rat hepatocytes. Genistein 7-β-D-Glucuronide undergoes distinct deconjugation in different functional assays. Genistein 7-β-D-Glucuronide is produced via hepatic microsomal glucuronidation and shows a mild age-related increase in intrinsic clearance in male F344 rats. Genistein 7-β-D-Glucuronide can be used for research on metabolism .
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- HY-176515
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Ciprofol Glucuronide
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Drug Metabolite
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Neurological Disease
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Cipepofol glucuronide (Ciprofol Glucuronide) (M4) is a glucuronide metabolite of Ciprofol (HY-116152). Cipepofol glucuronide has no significant inhibitory activity toward P450s and UDP-glucuronosyltransferases (UGTs), and it has a lower risk of acting as a perpetrator for drug-drug interactions (DDIs). Cipepofol glucuronide can be used for anesthesia research .
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- HY-W585842
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Endogenous Metabolite
ATP-binding cassette (ABC) transporters
OAT
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Others
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Estradiol 3-glucuronide is an estrogen metabolite, which is a glucuronide conjugate formed from Estradiol (HY-B0141) via catalysis by uridine diphosphate glucuronosyltransferases in tissues such as the liver. Estradiol 3-glucuronide is a potent substrate of Mrp2, with an S50 value of 55.7 μM. Estradiol 3-glucuronide achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and OATP2B1, as well as apical efflux via MRP2 and BCRP .
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- HY-137959
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β-glucuronidase
Drug Metabolite
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Metabolic Disease
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Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions .
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- HY-148225
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Drug Metabolite
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Cancer
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Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .
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- HY-W778608
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Quercetin 7-O-β-Glucuronide
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Drug Metabolite
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Inflammation/Immunology
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Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a metabolite of Quercetin (HY-18085), can be isolated from Madagascarian Uncarina species. Quercetin 7-glucuronide can inhibit LDL oxidation .
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- HY-W416250
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Drug Metabolite
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Cardiovascular Disease
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p-Cresol glucuronide, a metabolite of p-cresol, is a prototype protein-bound uremic toxin. p-Cresol glucuronide is associated with chronic kidney disease (CKD) .
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- HY-W588194
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Drug Metabolite
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Neurological Disease
Metabolic Disease
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Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function .
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- HY-W121901
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(S)-Naproxen-β-D-Glucuronide
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COX
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Inflammation/Immunology
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Naproxen glucuronide ((S)-Naproxen-β-D-glucuronide) is a non-selective COX inhibitor. Naproxen glucuronide, a metabolite of naproxen, is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (the same as ibuprofen) that relieves pain, fever, swelling, and stiffness .
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- HY-N11429
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Endogenous Metabolite
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Metabolic Disease
Cancer
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Glycochenodeoxycholic acid 3-glucuronide is a type of steroid glucuronide and a plasma metabolite that can be used in the research of biomarkers for diabetes and hepatocellular carcinoma (HCC) .
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- HY-N12394
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Reactive Oxygen Species (ROS)
NO Synthase
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Inflammation/Immunology
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Norwogonin-8-O-glucuronide is a glucuronide that can be isolated from Scutellaria indica. Norwogonin-8-O-glucuronide has anti-inflammatory activity. Norwogonin-8-O-glucuronide is a flavone glycoside. Norwogonin-8-O-glucuronide inhibits NO production in macrophage RAW264.7 cells with an IC50 above 30 μM .
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- HY-W766140
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4-Hydroxy duloxetine Glucuronide sodium; LY550408 sodium
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Drug Metabolite
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Metabolic Disease
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4-Hydroxy duloxetine β-D-glucuronide (4-Hydroxy duloxetine glucuronide) sodium is a major metabolite of Duloxetine (HY-B0161). 4-Hydroxy duloxetine β-D-glucuronide sodium is promising for research of hepatic or renal impairment .
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- HY-137426A
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- HY-W767164
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Biochemical Assay Reagents
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Cardiovascular Disease
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Deferiprone O-β-D-glucuronide sodium is a novel orally active iron chelator. Deferiprone O-β-D-glucuronide sodium can be used to investigate its ability to reduce iron burden in patients with β-thalassemia .
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- HY-126423
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Isorhamnetin 3-O-Glucuronide
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Apoptosis
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Cancer
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Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase .
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- HY-138011
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Dolutegravir Glucuronide; DTG Glucuronide
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Biochemical Assay Reagents
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Others
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Dolutegravir O-β-D-glucuronide (Dolutegravir glucuronide) is a compound used for the simultaneous determination of rilpivirine and dolutegravir concentrations in human plasma.
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- HY-N1454R
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Apigenin 7-O-Glucuronide (Standard)
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Reference Standards
MMP
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Cancer
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Apigenin-7-glucuronide (Standard) is the analytical standard of Apigenin-7-glucuronide. This product is intended for research and analytical applications. Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.
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- HY-135391S
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Ezetimibe Glucuronide-d4; Ezetimibe β-D-Glucuronide-d4
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Drug Metabolite
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Metabolic Disease
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Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity . Ezetimibe is a potent cholesterol absorption inhibitor .
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- HY-W016034
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p-Acetamidophenyl β-D-Glucuronide sodium salt; p-AAPG sodium salt
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Drug Metabolite
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Infection
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Acetaminophen glucuronide is a safe and effective
antipyretic analgesic. Acetaminophen glucuronide is potentially toxic to liver
and kidney .
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- HY-123742
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P-glycoprotein
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Metabolic Disease
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Estradiol 3-sulfate 17-glucuronide potassium is metabolite of estradiol. Estradiol 3-sulfate 17-glucuronide potassium inhibits multidrug resistance protein (MRP) mediated 17β -Estradiol 17-(β -D-Glucuronide) transport with a Ki of 22 μM .
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- HY-136307S
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Isotope-Labeled Compounds
Parasite
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Infection
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Tizoxanide-d4 glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum .
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- HY-G0020S1
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- HY-172565
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SCH 56592 D-Glucuronide
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Drug Metabolite
UGT
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Infection
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Posaconazole D-glucuronide (SCH 56592 D-glucuronide) is a glucuronide metabolite of the antifungal agent Posaconazole (HY-17373). Posaconazole D-glucuronide can be formed in human liver microsomes catalyzed by UGT1A4 .
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- HY-W587451
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OCA-3-Glucuronide disodium
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FXR
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Metabolic Disease
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Cholic acid 3-O-glucuronide (OCA-3-glucuronide) disodium is a farnesoid X receptor (FXR) agonist with an EC50 value of 91.5 μM. Cholic acid 3-O-glucuronide is promising for research of bile acid metabolism and detoxification .
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- HY-141914S
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- HY-129889
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Febuxostat acyl-β-D-Glucuronide
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Drug Metabolite
Xanthine Oxidase
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Metabolic Disease
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Febuxostat acyl glucuronide (Febuxostat acyl-β-D-glucuronide) is a metabolite of Febuxostat (HY-14268). Febuxostat is a potent, selective and non-purine xanthine oxidase (XO) inhibitor .
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- HY-W040047S
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Endogenous Metabolite
Isotope-Labeled Compounds
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Endocrinology
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Pregnanediol 3-glucuronide is the main end-metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is a metabolite of Progesterone formed by hydroxylation and glucuronidation in the liver, with high hydrophilicity and easy excretion through urine. Pregnanediol 3-glucuronide excretion rate of ≥ 9 μmol/24 h can serve as biochemical evidence of ovulation. Pregnanediol 3-glucuronide reflects the quality of the luteal phase, and a level of < 7 μmol/24 h may indicate anovulation or luteal insufficiency. Pregnanediol 3-glucuronide holds significant importance in monitoring female reproductive health, assessing pregnancy, and diagnosing endocrine disorders.
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- HY-143915S
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- HY-N12469
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Others
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Others
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Gypsogenin 3-O-glucuronide is a glucuronide that can be isolated from Gypsophila. Gypsogenin 3-O-glucuronide has cytotoxic effect on THP-1 cells .
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- HY-137339
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Drug Metabolite
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Others
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Amitriptyline N-β-D-glucuronide is an ammonium glucuronide and an urinary excretion metabolite of amitriptyline .
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- HY-160078
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Biochemical Assay Reagents
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Metabolic Disease
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Deferiprone O-β-D-glucuronide is a novel orally active iron chelator. Deferiprone O-β-D-glucuronide can be used to investigate its ability to reduce iron burden in patients with β-thalassemia .
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- HY-137321
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Estriol 3-β-D-Glucuronide sodium salt
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Endogenous Metabolite
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Metabolic Disease
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Estriol 3-glucuronide (Estriol 3-β-D-Glucuronide) sodium salt is a metabolite of Estriol. Estriol 3-glucuronide sodium salt competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide (4Mu-GlcU). Estriol 3-glucuronide sodium salt is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc) .
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- HY-167638
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4-HPR-O-Glucuronide
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Drug Metabolite
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Cancer
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Fenretinide glucuronide (4-HPR-O-glucuronide) is a metabolite formed from Fenretinide (HY-15373) through glucuronidation. The formation of Fenretinide glucuronide enhances the water solubility of Fenretinide and facilitates its excretion. Fenretinide glucuronide holds potential for research in the field of cancer .
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- HY-113018
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- HY-143957S
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- HY-137781
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- HY-154762S
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- HY-125370S
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- HY-144247S
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- HY-143927S
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- HY-143911S
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- HY-144201S
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- HY-151706S
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- HY-137301S
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- HY-W767389
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- HY-116029
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- HY-143929S
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- HY-113169
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- HY-W016034R
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p-Acetamidophenyl β-D-Glucuronide sodium salt (Standard); p-AAPG sodium salt (Standard)
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Drug Metabolite
Reference Standards
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Infection
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Acetaminophen glucuronide (sodium salt) (Standard) is the analytical standard of Acetaminophen glucuronide (sodium salt). This product is intended for research and analytical applications. Acetaminophen glucuronide is a safe and effective
antipyretic analgesic. Acetaminophen glucuronide is potentially toxic to liver
and kidney .
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- HY-135581
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Estrogen Receptor/ERR
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Endocrinology
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Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
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- HY-W016034S
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p-Acetamidophenyl β-D-Glucuronide-d3 sodium salt; p-AAPG-d3 sodium salt
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Isotope-Labeled Compounds
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Others
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Acetaminophen glucuronide-d3 sodium salt is the deuterium labeled Acetaminophen glucuronide sodium salt.
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- HY-135582S
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Estrogen Receptor/ERR
Isotope-Labeled Compounds
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Endocrinology
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Raloxifene 4'-glucuronide-d4 is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
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- HY-144166S
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- HY-132618S
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- HY-113018A
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(S)-Ibuprofen Glucuronide
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Drug Metabolite
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Inflammation/Immunology
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(S)-Ibuprofen acyl-β-D-glucuronide ((S)-Ibuprofen glucuronide) is a compound used to study the metabolism and pharmacokinetics of S-ibuprofen, a non-steroidal anti-inflammatory drug. (S)-Ibuprofen acyl-β-D-glucuronide is an acylglucuronic acid metabolite produced by S-ibuprofen in the liver .
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- HY-135582S1
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Isotope-Labeled Compounds
Estrogen Receptor/ERR
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Endocrinology
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Raloxifene 4'-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
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- HY-135581S1
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Isotope-Labeled Compounds
Estrogen Receptor/ERR
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Endocrinology
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Raloxifene 6-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
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- HY-111587
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Drug Derivative
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Cardiovascular Disease
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Ifenprodil glucuronide is a derivative of Ifenprodil. Ifenprodil is a vasodilator and an inhibitor of platelet aggregation, and Ifenprodil glucuronide has no effect on platelet aggregation and arterial contraction .
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- HY-N12028
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Others
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Others
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Acacetin 7-O-glucuronide is a glucuronide isolated from the methanolic leaf extract of Acacetin. Acacetin 7-O-glucuronide has potential applications in the development of nutraceuticals and pharmaceutical formulations .
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- HY-167859
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Hispidulin 7-O-Glucuronide; Hispidulin 7-O-β-D-glucuronopyranoside; 6-O-Methylscutellarin
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Others
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Others
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Hispidulin 7-glucuronide (Hispidulin 7-O-glucuronide) is a phenolic compound derived from Salvia that exhibits antioxidant activity .
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- HY-W700448
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- HY-135956
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- HY-W699926
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(R)-Naproxen-β-D-Glucuronide
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Biochemical Assay Reagents
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(R)-Naproxen acyl-β-D-glucuronide ((R)-Naproxen-β-D-glucuronide) is a compound metabolite with anti-inflammatory activity. (R)-Naproxen acyl-β-D-glucuronide can serve as a sensitive fluorescent substrate for proglutamyl peptidase 1, which produces a blue reaction after cleavage.
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- HY-W726630
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- HY-W766163
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Isotope-Labeled Compounds
Drug Metabolite
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Others
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7-Hydroxy coumarin glucuronide-d5 sodium is the deuterium labeled 7-Hydroxy coumarin glucuronide sodium (HY-120201). 7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin .
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- HY-113018S
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- HY-W588241
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- HY-145480
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Silodosin β-D-Glucuronide sodium
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Drug Metabolite
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Others
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Silodosin Glucuronide sodium (Silodosin β-D-glucuronide sodium) is the metabolite of Silodosin (HY-10122). Silodosin is a selective and orally active antagonist for α1A-adrenergic receptor (α1A-AR) with Ki of 0.036 nM .
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- HY-137522A
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3'-Azido-3'-deoxythymidine β-D-Glucuronide
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Drug Metabolite
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Others
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Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .
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- HY-W777433
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Endogenous Metabolite
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Infection
Others
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Cyclobenzaprine b-D-glucuronide is a metabolite of Cyclobenzaprine. Cyclobenzaprine b-D-glucuronide can be used to treat diseases associated with coronavirus infection. Cyclobenzaprine b-D-glucuronide can be used to study the metabolic pathways of Cyclobenzaprine in the body and as a potential candidate for studying coronavirus treatment .
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- HY-19866
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YM-222714
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Factor Xa
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Cardiovascular Disease
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Darexaban glucuronide (YM-222714) is a active metabolite of darexaban (YM150). Darexaban glucuronide has an oral activity and antithrombotic effect .
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-
- HY-N18207
-
|
|
Drug Derivative
|
Others
|
|
Pinocembrin-7-O-glucuronide is a flavanone glucuronide found in the stems and leaves of Scutellaria baicalensis Georgi .
|
-
- HY-W344531
-
-
- HY-W718678
-
|
|
Drug Metabolite
|
Cancer
|
|
6-Hydroxymelatonin glucuronide is a metabolite of Melatonin (HY-B0075). 6-Hydroxymelatonin glucuronide can be used for the research on the diagnosis of hepatocellular carcinoma (HCC) .
|
-
- HY-150162
-
|
T4-Glc
|
Drug Metabolite
|
Others
|
|
Thyroxine 4'-O-β-D-glucuronide (T4-Glc) is a conjugate of Thyroxine (T4) and Glucuronic acid. Thyroxine 4'-O-β-D-glucuronide is a major metabolite of Thyroxine (HY-18341) .
|
-
- HY-186081
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
Ramiprilat acyl-β-D-glucuronide is an acyl glucuronide metabolite of Ramiprilat (HY-B0279). Ramiprilat acyl-β-D-glucuronide undergoes methylation on its glucuronic acid moiety during solid phase extraction with strong cation exchanger cartridges, forming a methylated derivative. Ramiprilat acyl-β-D-glucuronide undergoes in-source conversion to Ramiprilat in mass spectrometry, with conversion extent proportional to declustering potential voltage .
|
-
- HY-173577
-
-
- HY-W711011
-
|
|
Drug Derivative
|
Metabolic Disease
|
|
Flufenamic acid glucuronide is an acyl-linked glucuronide of Flufenamic acid (HY-B1221). Flufenamic acid glucuronide can be used for the research of acyl glucuronide rearrangement and drug metabolism .
|
-
- HY-N13065
-
|
|
Drug Metabolite
|
Others
|
|
Quercetin 4′-glucuronide (Compound P3) is a Quercetin (HY-18085) metabolite. Quercetin 4′-glucuronide can trap free radical .
|
-
- HY-W121887
-
|
Zomepirac Glucuronide
|
Dipeptidyl Peptidase
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Zomepirac acyl-O-β-D-glucuronide (Zomepirac glucuronide) is a dipeptidyl peptidase IV Inhibitor. Zomepirac acyl-O-β-D-glucuronide is an unstable and chemically reactive metabolite of Zomepirac (HY-B0890A). Zomepirac acyl-O-β-D-glucuronide forms covalent adducts with cell membrane glycoproteins. Zomepirac acyl-O-β-D-glucuronide can be used for research on immunotoxicity .
|
-
- HY-W803819S
-
-
- HY-137301R
-
|
|
Drug Metabolite
Reference Standards
|
Cancer
|
|
Mycophenolic acid glucuronide (Standard) is the analytical standard of Mycophenolic acid glucuronide. This product is intended for research and analytical applications. Mycophenolic acid glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic acid glucuronide shows anti-tumor activity and can be used in adenocarcinoma research .
|
-
- HY-W701234
-
-
- HY-W707802
-
-
- HY-W587561
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Glycochenodeoxycholic acid 3-glucuronide disodium is a type of steroid glucuronide and a plasma metabolite that can be used in the research of biomarkers for diabetes and hepatocellular carcinoma (HCC) .
|
-
- HY-180680
-
-
- HY-113083A
-
|
APAP-glu potassium
|
Drug Metabolite
|
Others
|
|
Acetaminophen glucuronide potassium (APAP-glu potassium) is the inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen glucuronide potassium can be used as a biomarker to measure glucuronidation activity or hepatic drug metabolism capacity .
|
-
- HY-N9440
-
|
|
Drug Metabolite
|
Inflammation/Immunology
Cancer
|
|
7-Hydroxycoumarin glucuronide is a transport substrate and main human coumarin metabolite. 7-Hydroxycoumarin glucuronide undergoes ATP-dependent efflux transport via MRP3 and MRP4. 7-Hydroxycoumarin glucuronide undergoes active transport processes for urinary excretion and is primarily excreted into urine in humans.
|
-
- HY-172559
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
Solifenacin N-glucuronide is a metabolite formed by direct glucuronidation of the muscarinic receptor antagonist Solifenacin (HY-A0034). The levels of Solifenacin N-glucuronide are associated with diseases such as hepatic impairment .
|
-
- HY-N2481
-
|
Oroxyloside; Oroxylin A-7-O-β-D-Glucuronide
|
Prolyl Endopeptidase (PREP)
Drug Metabolite
JNK
PPAR
NF-κB
Interleukin Related
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .
|
-
- HY-113104S
-
|
ADT-G-d4 sodium
|
Isotope-Labeled Compounds
|
Others
|
|
Androsterone glucuronide-d4 (sodium) (ADT-G-d4 sodium) is the deuterium labeled Androsterone glucuronide sodium .
|
-
- HY-W585876
-
|
|
FXR
|
Metabolic Disease
|
|
Chenodeoxycholic acid 3-glucuronide is a metabolite of Chenodeoxycholic acid that can activate the key nuclear receptor (FXR), with an EC50 of 8 μM, and in HEK293T cells, the EC50 for activating FXR is 11 μM .
|
-
- HY-W653919
-
|
|
Isotope-Labeled Compounds
Drug Metabolite
|
Cancer
|
|
SN-38 glucuronide-d3 is deuterium labeled SN-38 glucuronide. SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
|
-
- HY-137522S
-
|
3'-Azido-3'-deoxythymidine β-D-Glucuronide-d3 sodium
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Zidovudine O-β-D-glucuronide-d3 sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .
|
-
- HY-113376
-
|
Etio-G
|
Endogenous Metabolite
Drug Metabolite
|
Metabolic Disease
|
|
Etiocholanolone glucuronide (Etio-G) is the metabolite of Etiocholanolone (HY-113320) that is generated in the liver by UDP glucuonyltransferase. Etiocholanolone glucuronide is promising for research of metabolic-related diseases .
|
-
- HY-N8841
-
|
|
Others
|
Others
|
|
Daidzein-7-O-glucuronide (compound 3) is a main metabolite of daidzein. Daidzein-7-O-glucuronide has oral activity .
|
-
- HY-150159S
-
|
|
Isotope-Labeled Compounds
Drug Metabolite
|
Neurological Disease
Metabolic Disease
|
|
Cotinine-d3 N-β-D-Glucuronide is the deuterium labeled Cotinine N-β-D-Glucuronide (HY-W588194). Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function .
|
-
- HY-151027S
-
-
- HY-N11026
-
|
|
Others
|
Others
|
|
22-Beta-Acetoxyglycyrrhizin is a triterpene glucuronide that can be isolated from the roots of Glycyrrhiza .
|
-
- HY-155792
-
|
|
Drug Metabolite
|
Others
|
|
Troglitazone glucuronide (Compound M2) is an initial metabolite of troglitazone in the liver .
|
-
- HY-113104
-
|
ADT-G
|
Endogenous Metabolite
Drug Metabolite
|
Metabolic Disease
|
|
Androsterone glucuronide (ADT-G) is one of the main metabolites of oral testosterone in humans and can be found in urine. The level of Androsterone glucuronide can reflect the absorption and hepatic metabolism of testosterone .
|
-
- HY-113083R
-
|
APAP-glu (Standard)
|
Reference Standards
Drug Metabolite
Endogenous Metabolite
|
Others
|
|
Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
|
-
- HY-N1463R
-
|
Luteolin 7-Glucuronide (Standard)
|
Reference Standards
MMP
|
Neurological Disease
Inflammation/Immunology
|
|
Luteolin 7-O-glucuronide (Standard) is the analytical standard of Luteolin 7-O-glucuronide. This product is intended for research and analytical applications. Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .
|
-
- HY-N2376
-
|
|
Glycosidase
Amylases
NF-κB
|
Metabolic Disease
Inflammation/Immunology
|
|
Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC50 values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury .
|
-
- HY-N2481R
-
|
Oroxyloside (Standard); Oroxylin A-7-O-β-D-Glucuronide (Standard)
|
Reference Standards
Prolyl Endopeptidase (PREP)
Drug Metabolite
JNK
PPAR
NF-κB
Interleukin Related
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Oroxylin A-7-O-glucuronide (Standard) is the analytical standard of Oroxylin A-7-O-glucuronide (HY-N2481). This product is intended for research and analytical applications. Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .
|
-
- HY-N2376R
-
|
|
Reference Standards
Glycosidase
Amylases
NF-κB
|
Metabolic Disease
Inflammation/Immunology
|
|
Chrysin-7-O-glucuronide (Standard) is the analytical standard of Chrysin-7-O-glucuronide (Hy-N2376). This product is intended for research and analytical applications. Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC50 values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury .
|
-
- HY-N7390
-
-
- HY-138795
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer .
|
-
- HY-W588194S
-
-
- HY-180679
-
-
- HY-143953S
-
-
- HY-N18372
-
|
|
Others
|
Others
|
|
Hispidulin 7-O-glucuronide methyl ester is a flavone glycoside. Hispidulin 7-O-glucuronide methyl ester can be found in the aerial part of Centaurea furfuracea .
|
-
- HY-138290
-
-
- HY-W353102
-
|
|
Endogenous Metabolite
P-glycoprotein
|
Metabolic Disease
|
|
Estradiol 17-(β-D-Glucuronide) is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) can be used in studies related to intrahepatic cholestasis .
|
-
- HY-129987
-
|
|
Endogenous Metabolite
P-glycoprotein
|
Metabolic Disease
|
|
Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) sodium is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) sodium regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) sodium induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) sodium can be used in studies related to intrahepatic cholestasis .
|
-
- HY-W008917S1
-
-
- HY-W713877
-
|
Montelukast AG
|
Drug Metabolite
|
Others
|
|
Montelukast acyl-b-D-glucuronide (Montelukast AG) is a acyl glucuronide metabolite of Montelukast (HY-13315A) .
|
-
- HY-W701833S
-
-
- HY-137522AS1
-
|
3'-Azido-3'-deoxythymidine β-D-Glucuronide-13C6
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Zidovudine Glucuronide- 13C6 (3'-Azido-3'-deoxythymidine β-D-glucuronide- 13C6) is 13C labeled Zidovudine O-β-D-glucuronide. Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .
|
-
- HY-118774R
-
|
|
Reference Standards
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Propofol β-D-glucuronide (Standard) is the analytical standard of Propofol β-D-glucuronide. This product is intended for research and analytical applications. Propofol β-D-glucuronide is a metabolite of Propofol sulfate and can be used for diagnosis to distinguish colorectal cancer from healthy individuals .
|
-
- HY-126848
-
|
D-1-O-G
|
Drug Metabolite
SOD
COX
Reactive Oxygen Species (ROS)
OAT
|
Inflammation/Immunology
|
|
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, COX-1 inhibitory activity (IC50 = 0.620 μM), and COX-2 inhibitory activity (IC50 = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of OATP2B1. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers .
|
-
- HY-118774S
-
-
- HY-W701013
-
-
- HY-142598S
-
-
- HY-142266S
-
-
- HY-132480S
-
-
- HY-141530
-
-
- HY-N4099
-
|
|
Drug Metabolite
|
Inflammation/Immunology
|
|
Luteolin-3-O-beta-D-glucuronide, a glucuronide derivative of Luteolin (HY-N0162), is found in the leaves of Rosmarinus officinalis L. Luteolin-3-O-beta-D-glucuronide inhibits nitrite production in macrophages and binds strongly to FYN kinase .
|
-
- HY-142258S
-
-
- HY-N17334
-
|
|
Others
|
Others
|
|
Acacetin 7-glucurono-(1→2)-glucuronide (compound 12) is a flavonoid compound present in the aerial parts of Callicarpa kwangtungensis Chun .
|
-
- HY-W777677
-
-
- HY-W769286
-
|
|
Isotope-Labeled Compounds
HDAC
|
Cancer
|
|
Valproic acid β-D-glucuronide-d15 is the deuterium labeled Valproic acid β-D-glucuronide (HY-W400496). Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .
|
-
- HY-N4099R
-
|
|
Reference Standards
Drug Metabolite
|
Inflammation/Immunology
|
|
Luteolin-3-O-beta-D-glucuronide (Standard) is the analytical standard of Luteolin-3-O-beta-D-glucuronide (HY-N4099). This product is intended for research and analytical applications. Luteolin-3-O-beta-D-glucuronide, a glucuronide derivative of Luteolin (HY-N0162), is found in the leaves of Rosmarinus officinalis L. Luteolin-3-O-beta-D-glucuronide inhibits nitrite production in macrophages and binds strongly to FYN kinase .
|
-
- HY-148002
-
|
|
Drug Metabolite
|
Others
|
|
1'-Hydroxy Midazolam-β-D-glucuronide is a β-D-glucuronide that acts as a drug metabolite, human urine metabolite, and human serum metabolite .
|
-
- HY-137160
-
|
|
COX
|
Inflammation/Immunology
|
|
(±)-Ketoprofen glucuronide is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) Ketoprofen (HY-B0227) .
|
-
- HY-W740060
-
|
|
Phosphodiesterase (PDE)
BCRP
|
Others
|
|
Dipyridamole Mono-O-β-D-glucuronide (compound M4) is a derivative of the phosphodiesterase (PDE) and BCRP inhibitor Dipyridamole (HY-B0312) and is an O-glucuronide .
|
-
- HY-172338
-
|
CHZ-N-Glc
|
Endogenous Metabolite
|
Others
|
|
Chlorzoxazone-N-glucuronide is a phase II metabolite of the skeletal muscle relaxant – Chlorzoxazone. Chlorzoxazone-N-glucuronide can be synthesized via glucuronidation of chlorozoxazone by UGT1A9 .
|
-
- HY-167814S
-
|
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Metabolic Disease
|
|
Deferiprone-d3 3-O-Beta-D-Glucuronide Sodium Salt is the deuterium labeled Deferiprone O-β-D-glucuronide (HY-160078). Deferiprone O-β-D-glucuronide is a novel orally active iron chelator. Deferiprone O-β-D-glucuronide shows the capability of reducing the iron burden in patients with β-thalassemia .
|
-
- HY-N6879R
-
|
|
Reference Standards
Others
|
Metabolic Disease
|
|
DiosMetin 7-O-β-D-Glucuronide (Standard) is the analytical standard of DiosMetin 7-O-β-D-Glucuronide. This product is intended for research and analytical applications. DiosMetin 7-O-β-D-Glucuronide is an antioxidant constituent in the fruits of Luffa cylindrical .
|
-
- HY-113083
-
|
APAP-glu
|
Drug Metabolite
Endogenous Metabolite
|
Others
|
|
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
|
-
- HY-122317
-
|
|
Drug Metabolite
|
Others
|
|
Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation .
|
-
- HY-141903S
-
-
- HY-D1460
-
|
|
Bacterial
β-glucuronidase
|
Infection
|
|
Fluorescein Di-β-D-Glucuronide is an orally active fluorescent probe substrate and an indicator of β-glucuronidase (βG) activity in intestinal bacteria. Fluorescein Di-β-D-Glucuronide can be used for non-invasive time-lapse optical imaging of βG activity in intestinal bacteria in nude mice. Fluorescein Di-β-D-Glucuronide supports the quantitative analysis of bacterial βG enzyme activity and inhibition .
|
-
- HY-W756134
-
|
|
Isotope-Labeled Compounds
Drug Metabolite
FXR
|
Metabolic Disease
|
|
Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d5 sodium is the deuterium labeled Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium. Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium is a metabolite of Chenodeoxycholic Acid (HY-76847) .
|
-
- HY-W766293
-
-
- HY-W766332
-
|
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
7-Hydroxy coumarin glucuronide sodium- 13C6 is the 13C-labeled 7-Hydroxy coumarin glucuronide sodium (HY-120201). 7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin .
|
-
- HY-W752886
-
|
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
|
Cancer
|
|
Estradiol 3-d3 (β-D-Glucuronide) sodium is the deuterium labeled Estradiol 3-(β-D-Glucuronide) sodium (HY-N7755). Estradiol 3-(β-D-Glucuronide) sodium is the glucuronic acid derivative of estradiol (HY-B0141). Estradiol 3-(β-D-Glucuronide) sodium is radiolabeled for use in tumor imaging and biodistribution studies .
|
-
- HY-122813
-
|
|
Drug Metabolite
Thrombin
|
Cardiovascular Disease
|
|
Dabigatran acyl-β-D-glucuronide is an active metabolite of the thrombin inhibitor Dabigatran (HY-10163). Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.
|
-
- HY-W746747
-
-
- HY-122813S3
-
-
- HY-122813S1
-
-
- HY-W854392
-
|
|
Biochemical Assay Reagents
|
|
|
3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) is a chromogenic substrate with biological activity for enzyme activity detection. 3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) can be used to evaluate biological reactions associated with glycosidases. 3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) shows a wide range of application potentials in compound discovery and biomedical research.
|
-
- HY-W700378
-
|
|
Isotope-Labeled Compounds
HDAC
|
Cancer
|
|
Valproic acid β-D-glucuronide-d6-1 is the deuterium labeled Valproic acid β-D-glucuronide (HY-W400496). Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .
|
-
- HY-137426
-
-
- HY-W338768
-
-
- HY-W561088
-
-
- HY-W700465
-
|
|
Drug Metabolite
|
Others
|
|
Etodolac acyl glucuronide is a metabolite of the non-steroidal anti-inflammatory compound Etodolac (HY-76251) .
|
-
- HY-137083A
-
|
UGT1A4 chloride
|
Drug Metabolite
|
Neurological Disease
|
|
Trifluoperazine N-glucuronide (UGT1A4) chloride is a metabolite of the antipsychotic agent trifluoperazine. Trifluoperazine N-glucuronide (UGT1A4) chloridecatalyzes the imipramine and trifluoperazine Nglucuronide formation .
|
-
- HY-137083
-
|
UGT1A4
|
UGT
|
Metabolic Disease
|
|
Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .
|
-
- HY-N12025
-
|
|
Others
|
Others
|
|
Eriodictyol 7-O-glucuronide is a flavonoid isolated from Cosmos sulphureus .
|
-
- HY-W744370
-
-
- HY-W768439
-
-
- HY-135621
-
-
- HY-N13388
-
|
UGT1A6
|
Biochemical Assay Reagents
UGT
|
Others
|
|
5-Hydroxytryptophol-O-glucuronide (UGT1A6) is an authentic glucuronide standard and probe metabolite. 5-Hydroxytryptophol-O-glucuronide is used to detect the activity of human UGT1A6 in in vitro systems including human liver microsomes and recombinant UGT1A6 .
|
-
- HY-W410706
-
-
- HY-145736
-
|
|
Drug-Linker Conjugates for ADC
Apoptosis
|
Cancer
|
|
β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity .
|
-
- HY-142581S
-
-
- HY-120201
-
|
|
Drug Metabolite
|
Others
|
|
7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin .
|
-
- HY-W770285
-
-
- HY-N6851
-
|
Glycyrrhetic acid 3-O-mono-β-D-Glucuronide; 3-monoglucuronyl-glycyrrhetinic acid
|
Others
|
Inflammation/Immunology
|
|
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.
|
-
- HY-137912
-
|
|
Drug Metabolite
|
Endocrinology
Cancer
|
|
trans-Resveratrol-3-O-β-D-Glucuronide is an active metabolite of trans-resveratrol. trans-Resveratrol-3-O-β-D-Glucuronide reduces the proliferation of several intestinal cancer cell line. trans-Resveratrol-3-O-β-D-Glucuronide increases pyruvate production in livers .
|
-
- HY-141945S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Taurochenodeoxycholic acid-3-o-glucuronide-d4 (disodium) is the deuterium labeled Taurochenodeoxycholic acid-3-o-glucuronide .
|
-
- HY-154772S
-
-
- HY-Z3637
-
-
- HY-D0935
-
|
|
β-glucuronidase
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .
|
-
- HY-W585982S
-
-
- HY-44221
-
|
|
ADC Linker
|
Cancer
|
|
MAC glucuronide linker-1 is a claevable ADC linker for antibody-agent-conjugations (ADCs) .
|
-
- HY-W705647
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
rac Erythro Dihydrobupropion Beta-D-Glucuronide-d9 is the deuterium labeled rac Erythro Dihydrobupropion Beta-D-Glucuronide.
|
-
- HY-W740902
-
-
- HY-N19800
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
Anhydroicaritin-3,7-di-O-glucuronide is a diglucuronide metabolite of icaritin. Anhydroicaritin-3,7-di-O-glucuronide is also a conjugated metabolite derived from prenylated flavonoids of the genus *Epimedium* in rats. In an in vitro microsomal system, Anhydroicaritin-3,7-di-O-glucuronide is mainly catalyzed by UGT1A1 and UGT1A8. Anhydroicaritin-3,7-di-O-glucuronide is generated via sequential glucuronidation at the 3-OH and 7-OH sites of icaritin, or via further conversion from monoglucuronides of icaritin .
|
-
- HY-156180
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
DDC 3′-O-β-D glucuronide (compound 5) is a drug metabolite that can prevent the fibrillization and oligomerization of Aβ42. DDC 3′-O-β-D glucuronide has potential for the research of Alzheimer's disease .
|
-
- HY-150345
-
-
- HY-145736A
-
|
|
Drug-Linker Conjugates for ADC
Apoptosis
|
Cancer
|
|
β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity .
|
-
- HY-W354066
-
|
|
Biochemical Assay Reagents
|
|
|
Biochanin A-7-O-β-D-glucuronide is a glucuronidated derivative of phytoestrogen, which has the ability to study the metabolic activity of phytoestrogen in the ecosystem. Biochanin A-7-O-β-D-glucuronide plays an important role in ecological research. Biochanin A-7-O-β-D-glucuronide is used to explore the interaction between plants and the environment.
|
-
- HY-137083S
-
|
UGT1A4-d3
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Trifluoperazine N-glucuronide-d3 is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .
|
-
- HY-113245
-
|
|
Endogenous Metabolite
|
Others
|
|
3-Indolyl-β-D-glucuronide, a chromogenic substrate for β-D-glucuronidase, employs in the detection and enumeration of E. coli, yielding a blue precipitate upon cleavage. 3-Indolyl-β-D-glucuronide in? patients' plasma act as a new indicator of renal failure .
|
-
- HY-W699225
-
-
- HY-W567866
-
-
- HY-W742736
-
-
- HY-128943
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) agent linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.Albumin-coupled MAC glucosidol-linked SN-38 shows good stability in mouse plasma .
|
-
- HY-44222
-
|
|
ADC Linker
|
Cancer
|
|
MAC glucuronide linker-2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-137783
-
-
- HY-137833
-
|
Naphthol AS-BI β-D-Glucuronide
|
Biochemical Assay Reagents
|
Others
|
|
Naphthol AS-BI β-D-Glucuronide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-13930
-
|
Quercetin 3-O-Glucuronide; Quercetin 3-Glucuronide
|
Endogenous Metabolite
|
Neurological Disease
Cancer
|
|
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor. Miquelianin is permeable to the blood-brain barrier .
|
-
- HY-D0935A
-
|
MUG
|
β-glucuronidase
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .
|
-
- HY-137912S1
-
-
- HY-142119S
-
-
- HY-120201S
-
-
- HY-W787458
-
-
- HY-W699866
-
-
- HY-W585982
-
-
- HY-W400496
-
|
|
HDAC
|
Cancer
|
|
Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .
|
-
- HY-W039892
-
|
pNPG_1
|
β-glucuronidase
|
Others
|
|
4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-Nitrophenol. 4-Nitrophenyl β-D-glucuronide is the chromogenic substrate for β-glucuronidase .
|
-
- HY-N15706
-
|
|
LDLR
|
Cardiovascular Disease
Metabolic Disease
|
|
Luteolin-7-O-β-D-glucuronide methyl ester is a flavonoid with antioxidative activity. Luteolin-7-O-β-D-glucuronide methyl ester exhibits potent antioxidative activity with an IC50 of 3.05 μg/mL in the NBT superoxide scavenging assay. Luteolin-7-O-β-D-glucuronide methyl ester inhibits LDL oxidation induced by Cu 2+ with the IC50 value is 71.13 μg/mL .
|
-
- HY-N9970
-
|
|
Others
|
Inflammation/Immunology
|
|
Apigenin 7-O-β-D-glucuronide ethyl ester is a flavonoid glucuronate ester that can be isolated from Scutellaria regeliana. Apigenin 7-O-β-D-glucuronide ethyl ester possesses anti-inflammatory activity on the release of β-glucuronidase from rat polymorphonuclear leukocytes (PNMs) induced by platelet activating-factor. Apigenin 7-O-β-D-glucuronide ethyl ester can be used for anti-inflammatory research .
|
-
- HY-W039893
-
-
- HY-N17672
-
|
|
Others
|
Others
|
|
Quercetin 3-O-β-D-glucuronide 6"-ethyl ester is a flavonoid. Quercetin 3-O-β-D-glucuronide 6"-ethyl ester can be extracted from flowers of Tamarix nilotica .
|
-
- HY-176078
-
|
|
Adrenergic Receptor
|
Others
|
|
4-Hydroxy xylazine O-glucuronide (lithium) is a metabolite of the α2-adrenergic receptor agonist xylazine. 4-Hydroxy xylazine O-glucuronide (lithium) can be synthesized from xylazine via the intermediate metabolite 4-hydroxy xylazine .
|
-
- HY-W145687
-
|
Diosgenin-3-O-Β-D-Glucuronide
|
Biochemical Assay Reagents
|
Others
|
|
Diosgenin-3-O-β-D-sodium glucuronide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-150985S
-
-
- HY-N8578
-
|
|
Others
|
Others
|
|
Luteolin 7,3′-di-O-glucuronide is a flavonoid compound of the luteolin family .
|
-
- HY-137188
-
-
- HY-132723AS
-
-
- HY-132723S
-
-
- HY-N16924
-
-
- HY-W749337
-
-
- HY-111812
-
|
|
Others
|
Neurological Disease
|
|
Tricin 7-O-glucuronide is an Alfalfa (Medicago sativa L.) flavonoid that can be obtained from the leaves of M. tenuifollium G. Forster .
|
-
- HY-N6879
-
|
|
Others
|
Metabolic Disease
|
|
DiosMetin 7-O-β-D-Glucuronide is an antioxidant constituent in the fruits of Luffa cylindrical .
|
-
- HY-W585920
-
|
|
FXR
|
Metabolic Disease
|
|
Chenodeoxycholic acid 24-acyl-β-D-glucuronide is a metabolite of Chenodeoxycholic Acid (HY-76847) .
|
-
- HY-W416222
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyl β-D-glucuronide sodium is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-136344
-
|
|
Drug Metabolite
|
Others
|
|
Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM .
|
-
- HY-137963
-
-
- HY-135245
-
|
SCH 488128; Ezetimibe hydroxy β-D-Glucuronide
|
Drug Metabolite
|
Cardiovascular Disease
|
|
Ezetimibe hydroxy glucuronide (SCH 488128) is a trace metabolite detected in dog and human plasma samples after oral administration of Ezetimibe (HY-17376) .
|
-
- HY-W700451
-
-
- HY-W587775
-
|
Acyl-MPAG
|
Drug Metabolite
|
Metabolic Disease
|
|
Mycophenolic acid acyl-β-D-glucuronide (Acyl-MPAG) is a metabolite of Mycophenolic acid (MPA) , an immunosuppressant.
|
-
- HY-W765751
-
-
- HY-W587537
-
|
|
FXR
|
Metabolic Disease
|
|
Deoxycholic Acid 3-O-beta-D-Glucuronide disodium salt is a bile acid receptor (FXR) agonist.
|
-
- HY-W568899
-
-
- HY-137816
-
|
|
β-glucuronidase
|
Others
|
|
6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt produces a salmon colored precipitate upon cleavage .
|
-
- HY-13930R
-
|
Quercetin 3-O-Glucuronide (Standard); Quercetin 3-Glucuronide (Standard)
|
Reference Standards
Endogenous Metabolite
|
Cancer
|
|
Miquelianin (Standard) is the analytical standard of Miquelianin. This product is intended for research and analytical applications. Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.
|
-
- HY-118774
-
-
- HY-W759947
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
24-Nor ursodeoxycholic acid-d5 acyl-b-D-glucuronide is the deuterium labeled 24-Nor ursodeoxycholic acid-d5 acyl-b-D-glucuronide (HY-W759947) .
|
-
- HY-W777236
-
|
|
Drug Metabolite
|
Others
|
|
N-Acetyl serotonin β-D-glucuronide is a glucuronidated metabolite of N-acetylserotonin (HY-107854) and a probe metabolite for UGT1A6 activity assays.N-Acetyl serotonin β-D-glucuronide forms from N-acetyl serotonin via glucuronidation catalyzed by a UGT enzyme .
|
-
- HY-W709715
-
|
|
Drug Derivative
|
Others
|
|
Dihydro ferulic acid 4-O-β-D-glucuronide is a natural product that can be found in asafoetida.
|
-
- HY-153642
-
-
- HY-142279S
-
-
- HY-136329
-
|
|
ADC Linker
|
Cancer
|
|
β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-W587912
-
|
|
Drug Derivative
|
Others
|
|
Glycodeoxycholic acid-3-O-b-glucuronide disodium is a β-D-glucopyranosiduronic acid derivative.
|
-
- HY-N10647
-
|
|
Others
|
Inflammation/Immunology
|
|
Isoscutellarein 8-O-β-D-glucuronide is a flavonoid antioxidant, can be isolated from Theobroma grandiflorum seeds .
|
-
- HY-W767663
-
-
- HY-N1463
-
|
Luteolin 7-Glucuronide
|
MMP
|
Neurological Disease
Inflammation/Immunology
|
|
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .
|
-
- HY-W154341
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3-Indolyl-β-D-glucuronide cyclohexanamine is the glucose component of X-Gluc staining buffer. 3-Indolyl-β-D-glucuronide cyclohexanamine can be used to detect gene expression. The active ingredient of the stain, β-Glucuronidase (GUS), reacts with the enzyme, causing the target gene to appear blue-purple in tissues or cells, so that the expression level and tissue distribution of the gene can be visually observed .
|
-
- HY-169528S
-
-
- HY-W145619
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Nitrophenyl α-D-Glucuronide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W708061
-
|
|
Biochemical Assay Reagents
|
|
|
Benoxaprofen glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
|
-
- HY-W401407
-
|
|
Drug Metabolite
Cytochrome P450
|
Metabolic Disease
|
|
Diosmetin-3-O-glucuronide is a major circulating metabolite of Diosmetin (HY-N0125) in plasma and in urine. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity .
|
-
- HY-W039885
-
-
- HY-128532A
-
|
|
Endogenous Metabolite
|
Others
|
|
Formononetin 7-O-β-D-glucuronide sodium is a metabolite of Formononetin (HY-N0183) and can be absorbed and metabolized through the intestine .
|
-
- HY-128532
-
-
- HY-N17775
-
|
Clerodendroside
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Scutellarein 4'-methyl ether 7-O-glucuronide (Clerodendroside) is a flavonoid inhibitor of acetylcholinesterase (AChE) (IC50=1 mg/mL). Scutellarein 4'-methyl ether 7-O-glucuronide can be isolated from Plectranthus barbatus. It also possesses antioxidant activity and can be used in research on neurological diseases such as Alzheimer's disease.
|
-
- HY-137909
-
-
- HY-137387
-
|
|
Drug Metabolite
|
Cardiovascular Disease
Others
|
|
Carvedilol Glucuronide is the metabolite of Carvedilol (HY-B0006). Carvedilol (BM 14190) is an antagonist for β/α-1 adrenergic receptor. Carvedilol inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol is an antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .
|
-
- HY-126373S1
-
|
SN-38G-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
SN-38 glucuronide- 13C6 is the 13C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
|
-
- HY-N12588
-
|
|
Others
|
Others
|
|
Quercetin 3-O-β-D-glucuronide-6″-methyl ester is a flavonoid isolated from Atraphaxis spinosa L .
|
-
- HY-181438
-
-
- HY-135588
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
Raloxifene 6,4'-Bis-β-D-glucuronide (compound IV) is a metabolite of Raloxifene. Raloxifene is a selective estrogen receptor antagonist for the prevention of osteoporosis .
|
-
- HY-N7035
-
|
Wogonoside methyl ester
|
Others
|
Metabolic Disease
|
|
Wogonin 7-O-beta-D-glucuronide methyl ester is a natural compound isolated from Huanglian Jiedutang .
|
-
- HY-W777361
-
|
11α-Glucuronylprogesterone
|
Drug Derivative
|
Metabolic Disease
|
|
11a-Hydroxy Progesterone b-D-Glucuronide (11α-Glucuronylprogesterone) is a progesterone derivative.
|
-
- HY-N10799
-
|
|
Others
|
Others
|
|
Oroxylin A 7-O-β-D-glucuronide methyl ester is a nature product that could be isolated form the roots of Scutellaria baicalensis Georgi .
|
-
- HY-126107
-
-
- HY-113105
-
|
Estriol 16-glucosiduronate
|
Endogenous Metabolite
|
Others
|
|
Estriol 16α-(β-D-glucuronide) is an endogenous metabolite present in Urine that can be used for the research of Pregnancy .
|
-
- HY-118634S
-
-
- HY-129993
-
-
- HY-162817
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N′-Nitrosonornicotine N-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-N12793
-
|
|
Others
|
Others
|
|
5,6-Dihydroxy-8-methoxyflavone-7-O-glucuronide (Compound 8) is a flavonoid glycoside and can be isolated from Scutellaria baicalensis .
|
-
- HY-W039888
-
-
- HY-171814
-
|
|
Drug-Linker Conjugates for ADC
N-myristoyltransferase
|
Cancer
|
|
Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 (Compound DC-2) is a drug-linker conjugate for ADC. Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 consists of a NMT inhibitor (HY-160945) and a stable and cleavable linker (Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)). Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 can be used for synthesis of ADCs .
|
-
- HY-N8029
-
|
|
Others
|
Others
|
|
6-Hydroxyapigenin 6-O-β-D-glucoside-7-O-β-D-glucuronide (compound 8) is a kind of flavonoid. 6-Hydroxyapigenin 6-O-β-D-glucoside-7-O-β-D-glucuronide can be isolated from the water extract of Carthamus tinctorius .
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-
- HY-126373
-
|
SN-38G
|
Drug Metabolite
|
Cancer
|
|
SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
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-
- HY-155313
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC50 value of 5.7 nM - 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects .
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-
![β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE](//file.medchemexpress.com/product_pic/hy-155313.gif)
- HY-118634
-
|
R-4G
|
FATP
|
Metabolic Disease
|
|
Trans-Resveratrol-4'-O-D-Glucuronide (R-4G) is a metabolite of resveratrol with anti-fat accumulation property, and can be used for metabolic research .
|
-
- HY-W399188
-
-
- HY-W354925
-
|
|
Biochemical Assay Reagents
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Others
|
|
Lumiracoxib acyl-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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-
- HY-W740133
-
|
|
Biochemical Assay Reagents
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Others
|
|
Rhein 8-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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-
- HY-W740685
-
|
|
Biochemical Assay Reagents
|
|
|
Deferasirox acyl-β-D-glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
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-
- HY-W777241
-
|
|
Biochemical Assay Reagents
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Others
|
|
Dexamethasone β-D-glucuronide (sodium) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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-
- HY-W328438
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mefenamic acyl-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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-
- HY-167818
-
|
|
Biochemical Assay Reagents
|
|
|
Bazedoxifene bis-β-D-glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
|
-
- HY-154774S
-
-
- HY-170056
-
-
- HY-153875
-
|
|
β-glucuronidase
Cytochrome P450
|
Metabolic Disease
|
|
Saccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM) .
|
-
- HY-W700345
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Desmethyl ranolazine β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-Glycan recognition and the role of glycans in biological systems. This field is closely related to basic research, biomedicine and biotechnology.
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-
- HY-W340093
-
|
|
Biochemical Assay Reagents
|
|
|
Probenecid acyl β-D-glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
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-
- HY-W777656
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Varenicline crbamoyl β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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-
- HY-137194
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Ethynyl estradiol 3-bD-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-Glycan recognition and the role of glycans in biological systems. This field is closely related to basic research, biomedicine and biotechnology.
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-
- HY-W778538
-
|
ADG
|
Biochemical Assay Reagents
|
Others
|
|
Alphadolone 21-β-D-glucuronide (ADG) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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-
- HY-W416264
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Aminophenyl β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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-
- HY-W777292
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Ethynyl estradiol 17-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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-
- HY-W587441
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Chloramphenicol 3-O-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-160251
-
|
(3'R,5k'S)-trans-3'-Hydroxycotinine Glucuronide
|
Drug Metabolite
|
Others
|
|
3-HC-Gluc ((3’R,5k’s)-trans-3’ -Hydroxycotinine glucuronide) The trans-structure of 3-HC, the main metabolite of nicotine .
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-
- HY-167927S
-
|
|
Isotope-Labeled Compounds
PARP
|
Cancer
|
|
Mycophenolic Acid-d3 Acyl-Beta-D-glucuronide is the deuterium labeled Mefuparib (HY-167927). Mefuparib (CVL218) is a poly ADP-ribose polymerase (PARP) inhibitor used in cancer research that exhibits potent brain penetration due to its high protein binding.
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-
- HY-W780205
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(Rac)-Hesperetin 3'-O-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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-
- HY-W740051
-
|
|
Biochemical Assay Reagents
|
Others
|
|
13-cis Retinoyl β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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-
- HY-N1439
-
|
Gypsogenin-3-O-(6-O-methyl)-glucoside
|
Others
|
Inflammation/Immunology
|
|
Methyl gypsogenin-3-O-glucuronide (Gypsogenin-3-O-(6-O-methyl)-glucoside) is a ubiquitous saponin precursor in plants of the genus Gypsophila .
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-
- HY-N12299
-
|
Quercetin 3-O-β-D-Glucuronide butyl ester
|
Others
|
Cancer
|
|
Parthenosin (Quercetin 3-O-β-D-glucuronide butyl ester) is a flavonoid, that can be isolated from the aerial parts of Calligoum polygonoides. Parthenosin shows cytotoxic activity against HepG2 and MCF-7 cell lines with IC50 values of 60.46 and 61.4 μg/mL, respectively .
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-
- HY-176333
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
|
Nebivolol O-β-D-glucuronide is a derivative of Nebivolol (HY-B0203). Nebivolol is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease .
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-
- HY-125156
-
|
BMS-801576
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Dapagliflozin-3-O-β-D-glucuronide (BMS-801576) is the metabolite of Dapagliflozin (HY-10450), and is formed in the liver and kidney by uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9). Dapagliflozin is a selective inhibitor for SGLT2, that can be used to improve glycemic control and attenuate type 2 diabetes .
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-
- HY-W791535
-
|
|
Biochemical Assay Reagents
|
|
|
4-Hydroxy propofol 1-O-β-D-glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
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-
- HY-W700218
-
|
|
Biochemical Assay Reagents
|
|
|
4-Hydroxy propofol 4-O-β-D-Glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
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-
- HY-167926S
-
|
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Mycophenolic Acid-d3 beta-D-Glucuronide is the deuterium labeled 3-Bromo-4,5-dihydroxybenzoic acid methyl ester (HY-167926). 3-Bromo-4,5-dihydroxybenzoic acid methyl ester is a marine-derived natural product known for its biological activity, specifically showcasing antioxidant properties and potential therapeutic applications against oxidative stress-related diseases.
|
-
- HY-126194
-
|
Ro 61-1448
|
Drug Metabolite
COMT
Amyloid-β
Apoptosis
Reactive Oxygen Species (ROS)
|
Others
|
|
Tolcapone 3-β-D-glucuronide (Ro 61-1448) is an O-methyl metabolite of Tolcapone (HY-17406) and is pharmacologically inactive. Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma .
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-
- HY-W006081
-
|
|
UGT
|
Others
|
|
3-Methyl-2-nitrophenol is a UDP-glucuronyltransferase (EC 2.4.1.17) acceptor substrate that can be confirmed to undergo glucuronidation catalyzed by the enzyme to form a glucuronide conjugate. 3-Methyl-2-nitrophenol functions as a substrate for conjugation, with glucuronidation forming a glucuronide conjugate that eliminates the parent compound’s characteristic yellow color. 3-Methyl-2-nitrophenol has higher lipid solubility that contributes to high glucuronidation conversion rate, and exhibits lower absorbance at 340 nm to act as a less interfering substrate for the NADH-NAD +-linked UDP-glucuronyltransferase assay .
|
-
- HY-W767542
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Dihydro Isoferulic Acid-d3 3-O-b-D-Glucuronide is the deuterium labeled (2S,3S,4S,5R,6S)-6-(5-(2-Carboxyethyl)-2-methoxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid (HY-W703563).
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-
- HY-148044
-
|
|
β-glucuronidase
Bacterial
|
Infection
|
|
UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes .
|
-
- HY-W048545
-
|
β-D-Glucopyranuronic acid, methyl ester, 2,3,4-triacetate
|
Drug Intermediate
|
Infection
|
|
2,3,4-Tri-O-acetyl-β-D-glucuronide methyl ester (β-D-Glucopyranuronic acid, methyl ester, 2,3,4-triacetate) is a synthetic intermediate in the synthesis of prodrug forms of the antitumor antibiotic Daunomycin (HY-13062A).
|
-
- HY-W014277
-
|
|
Environmental Pollutants
Drug Metabolite
|
Others
|
|
2,6-Diisopropylnaphthalene is a substituted naphthalene compound and metabolite precursor. 2,6-Diisopropylnaphthalene undergoes metabolism exclusively via oxidation of its isopropyl chain in Rattus norvegicus (rats), producing five major unconjugated urinary metabolites. 2,6-Diisopropylnaphthalene forms glucuronide conjugates of these metabolites, and a small amount of unchanged compound is excreted in urine .
|
-
- HY-157129
-
|
|
AMPK
|
Cardiovascular Disease
|
|
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy .
|
-
- HY-148379
-
|
|
Drug Intermediate
|
Others
|
|
Tetrahydrocortisone acetate is a intermediate product for production of tetrahydrocortisone 3-glucuronide .
|
-
- HY-148378
-
|
|
Drug Intermediate
|
Others
|
|
5β-Dihydrocortisone acetate can be used for the synthesis of tetrahydrocortisone 3-glucuronide .
|
-
- HY-N7176R
-
|
Kaempferol-3-Glucuronide (Standard); Kaempferol-3-O-Glucuronide (Standard)
|
Reference Standards
Interleukin Related
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Prosulfocarb (Standard) is the analytical standard of Prosulfocarb. This product is intended for research and analytical applications. Prosulfocarb is a herbicide with a rapidly growing use trend. Prosulfocarb is used in winter cereals to help address the problem of increasing biotic resistance of weeds to certain pesticides. Environmental and food effects of prosulfocarb have been observed, and its transfer pattern from target crops to non-target areas has been studied. The volatility effect of prosulfocarb is an important factor explaining the inefficiency of isolated area contamination and marginal protection against residue spread .
|
-
- HY-135591
-
-
- HY-W121884
-
-
- HY-W778608R
-
|
Quercetin 7-O-β-Glucuronide (Standard)
|
Drug Metabolite
Reference Standards
|
Inflammation/Immunology
|
|
Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .
|
-
- HY-125954
-
|
UDP-α-D-glucuronic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a glucuronic acid donor. Uridine diphosphate glucuronic acid transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid .
|
-
- HY-113249
-
-
- HY-158238S
-
-
- HY-135587
-
|
|
Drug Intermediate
|
Others
|
|
4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is used to synthesize Raloxifene 6-glucuronide .
|
-
- HY-50175A
-
-
- HY-50175
-
-
- HY-W309310
-
|
|
Histamine Receptor
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Etofesalamide is a nonsteroidal antiinflammatory agent. Etofesalamide has major phase II metabolites of glucoside and riboside conjugations (such as etofesalamide-2-glucuronide) in filamentous fungi. Etofesalamide can be used for allergic and autoimmune skin diseases like toacne, psoriasis and sensitization dermatitis research .
|
-
- HY-N0197
-
-
- HY-118724
-
|
NSC103055; Mandelonitrile beta-Glucuronide
|
Others
|
Others
|
|
Laetrile (NSC103055) is a natural product .
|
-
- HY-W750220
-
-
- HY-164340
-
|
|
Drug Metabolite
|
Cancer
|
|
Boc-NH-PAB(triacetyl-β-D-glucopyranuronate)-PNP (Compound 16) is a β-glucuronide-type linker precursor that couples with NeoDegrader P1 to synthesize the NeoDegrader P1-β-Glucuronide Linker Complex. Boc-NH-PAB(triacetyl-β-D-glucopyranuronate)-PNP and its derived linker-payload complexes can be used for the research of acute myeloid leukemia .
|
-
- HY-W777199
-
|
|
Drug Metabolite
|
Others
|
|
Tianeptine metabolite MC5 sodium salt is a major active metabolite of tianeptine. Tianeptine and MC5 metabolite are eliminated with bile as glucuronide and glutamine conjugates .
|
-
- HY-N0197R
-
-
- HY-W345885
-
|
|
β-glucuronidase
|
Metabolic Disease
|
Saccharic acid is a competitive and potent inhibitor of β-glucuronidase. Saccharic acid inhibits glucuronide synthesis. Saccharic acid as an efficient iron chelate to enhance photo-Fenton
degradation of organic contaminants .
|
-
- HY-117871
-
|
C.I. 37530
|
β-glucuronidase
|
Metabolic Disease
|
|
Naphthol AS-OL (C.I. 37530) is a glucuronide taht can be used as a substrate of β-glucuronidase. Naphthol AS-OL can be used to detect β-glucuronidase activity .
|
-
- HY-D1707
-
|
|
Fluorescent Dye
|
Others
|
|
FDGlcU can be used as a fluorescent probe for non-invasively image with a high level of fluorescent activity. FDGlcU is non-fluorescent when the fluorescein is conjugated with two mono-glucuronides (Ex/Em=480/514 nm) .
|
-
- HY-E70101B
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
α-Glucuronidase, Cellvibrio japonicus (EC 3.2.1.139), is a glycosidase that hydrolyzes O- and S-glycosides. Its two substrates are α-D-glucuronide and water, and its two products are an alcohol and D-glucuronic acid.
|
-
- HY-182255
-
|
|
Endogenous Metabolite
|
Others
|
|
ED-594 is the glucuronide form of NB-506. ED-594 is one of the major metabolites of NB-506 in rat bile, mouse liver microsomes, rat liver microsomes and human liver microsomes .
|
-
- HY-W008125S
-
|
Methyl acetobromo-α-D-glucuronate-13C6 methyl ester
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
Drug Intermediate
|
Cardiovascular Disease
|
|
Acetobromo-a-D-glucuronic acid- 13C6 methyl ester (Methyl acetobromo-α-D-glucuronate- 13C6 methyl ester) is 13C labeled Acetobromo-α-D-glucuronic acid methyl ester, 98% (HY-W008125). Acetobromo-α-D-glucuronic acid methyl ester, 98% is an intermediate. Acetobromo-α-D-glucuronic acid methyl ester, 98% can be used to synthesize HMR1098-S-Glucuronide Methyl Ester. HMR1098 is a novel KATP blocker that is metabolized to S-glucuronide in rat and dog bile. Acetobromo-α-D-glucuronic acid methyl ester, 98% can be used in the research of sudden cardiac death .
|
-
- HY-113095
-
γ-CEHC
1 Publications Verification
|
Drug Metabolite
Endogenous Metabolite
|
Others
|
|
γ-CEHC is a γ-tocopherol (HY-N7148) metabolite. γ-CEHC is mainly excreted into the urine rather than into the bile. γ-CEHC is present in conjugated form in human urine, mainly as glucuronide .
|
-
- HY-113972A
-
|
|
Drug Isomer
|
Inflammation/Immunology
|
|
(E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides .
|
-
- HY-E70973
-
|
|
Biochemical Assay Reagents
|
Others
|
|
β-Glucuronidase/Arylsulfatase, Helix pomatia is an enzyme that can be isolated from Helix pomatia with sulfatase activity. β-Glucuronidase/Arylsulfatase, Helix pomatia exhibits broad-spectrum specificity for hydrolyzing a variety of β-glucuronide and sulfate conjugate .
|
-
- HY-E70101A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
α-Glucuronidase, Opitutus terrae PB90-1 (EC 3.2.1.139), is a glycosidase that hydrolyzes O- and S-glycosides. Its two substrates are α-D-glucuronide and water, and its two products are an alcohol and D-glucuronic acid.
|
-
- HY-186048
-
|
|
Drug-Linker Conjugates for ADC
|
Infection
|
|
MC-VC-PAB-Daptomycin (Compound 54) is the linker-payload of an antibody-drug conjugate (ADC). β-Glucuronide-dPBD-PEG6-NH2 is composed of Daptomycin (HY-13631), a lipopeptide antibiotic, and the linker .
|
-
- HY-B0947
-
|
|
P-glycoprotein
Bacterial
|
Infection
|
|
Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG) .
|
-
- HY-119621
-
|
|
β-glucuronidase
DNA/RNA Synthesis
Apoptosis
|
Cancer
|
|
Aceglatone, an antineoplastic agent, is a β-glucuronidase inhibitor. Aceglatone is a compound that inhibits colon carcinogenesis and prevents the induction of colon cancer by inhibiting the hydrolysis of glucuronides. Aceglatone reduces cell proliferation, induces apoptosis and inhibits DNA synthesis in human colon cancer cells .
|
-
- HY-116802
-
|
|
Drug Derivative
Herbicide
|
Others
|
|
Bromobutide is an active ingredient in herbicides that kill weeds. Bromobutide has the highest control effect on Scirpus juncoides and Monochloa vaginalis, but has no inhibitory effect on weed seed germination. The main metabolites of bromobutide in rats are alcohol or phenol glucuronides, which enter the enterohepatic circulation .
|
-
- HY-137869
-
|
5-Bromo-6-chloro-3-indolyl β-D-Glucuronide cyclohexylammonium
|
Biochemical Assay Reagents
|
Others
|
|
Magenta-β-D-GlcA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W097018
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Iomeprol intermediate-1 (compound 5) is an iodinated polysaccharide compound used in the synthesis of contrast agents. The amino group of Iomeprol intermediate-1 can be coupled to the carboxyl group of the D-glucuronide subunit of non-animal stable hyaluronic acid (NASHA), providing a water-soluble, radiopaque moiety .
|
-
- HY-178293
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
N-Succinimidyl 3-maleimidopropionate (Compound MC1) is a Glucuronide-Gemcitabine conjugate. N-Succinimidyl 3-maleimidopropionate can be used to synthesize ADCs (such as cAc10ec-MC1). N-Succinimidyl 3-maleimidopropionate can be used in Hodgkin's lymphoma research .
|
-
- HY-B0947S1
-
|
|
P-glycoprotein
Bacterial
|
Infection
|
|
Sulfanitran- 13C6 is the 13C labeled Sulfanitran. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG).
|
-
- HY-B0947S
-
|
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
Sulfanitran-d4 is the deuterium labeled Sulfanitran. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG) .
|
-
- HY-B0947R
-
|
|
P-glycoprotein
Bacterial
Reference Standards
|
Infection
|
|
Sulfanitran (Standard) is the analytical standard of Sulfanitran. This product is intended for research and analytical applications. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG) .
|
-
- HY-W097018R
-
|
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
|
Iomeprol intermediate-1 (Standard) is the analytical standard of Iomeprol intermediate-1. This product is intended for research and analytical applications. Iomeprol intermediate-1 (compound 5) is an iodinated polysaccharide compound used in the synthesis of contrast agents. The amino group of Iomeprol intermediate-1 can be coupled to the carboxyl group of the D-glucuronide subunit of non-animal stable hyaluronic acid (NASHA), providing a water-soluble, radiopaque moiety .
|
-
- HY-158109
-
|
|
Antibody-Drug Conjugates (ADCs)
CD2
Topoisomerase
|
Cancer
|
|
M3554 is an anti-GD2 antibody-drug conjugate (ADC) based on the humanized anti-GD2 antibody. M3554 consists of the humanized monoclonal antibody hu14.18 (K322A) (HY-P991040) linked to a topoisomerase 1 inhibitor Exatecan (HY-13631) via a cleavable β-glucuronide linker. M3554 can be used for the study of neuroblastoma, osteosarcoma or glioma .
|
-
- HY-N6612
-
-
- HY-N6612A
-
|
|
Endogenous Metabolite
Toll-like Receptor (TLR)
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
D-Glucuronic acid sodium salt monohydrate is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid sodium salt monohydrate activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid sodium salt monohydrate and its derivative glucurono-lactone can serve as liver detoxifiers, and its derivatives also possess anti-tumor activity .
|
-
- HY-125954A
-
|
UDP-α-D-glucuronic acid ammonium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Uridine diphosphate glucuronic acid ammonium (UDP-α-D-glucuronic acid ammonium) is a glucuronic acid donor. Uridine diphosphate glucuronic acid ammonium transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid ammonium serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid .
|
-
- HY-115004
-
|
|
FAAH
|
Neurological Disease
|
|
MM-433593 is a potent and selective inhibitor of fatty acid amide hydrolase-1 (FAAH-1) that is orally administered to inhibit pain, inflammation, and related disorders. Pharmacokinetic studies of MM-433593 in macaques revealed a biphasic elimination profile with a rapid distribution phase and a slower elimination phase, with a systemic clearance of 8-11 mL/min/kg. MM-433593 exhibits moderate oral bioavailability (14-21%) and its metabolism primarily involves oxidation of the methyl group on the indole ring, resulting in a variety of sulfate, glucuronide, or glutathione-conjugated metabolites .
|
-
- HY-N6612R
-
|
|
Reference Standards
Endogenous Metabolite
Toll-like Receptor (TLR)
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
D-Glucuronic acid (Standard) is the analytical standard of D-Glucuronic acid. This product is intended for research and analytical applications. D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .
|
-
- HY-B0890R
-
|
McN-2783-21-98 (Standard)
|
PGE synthase
Reference Standards
|
Neurological Disease
Inflammation/Immunology
|
|
Zomepirac sodium salt (Standard) is the analytical standard of Zomepirac sodium salt (HY-B0890). This product is intended for research and analytical applications. Zomepirac sodium salt (McN-2783-21-98) is an orally active prostaglandin synthetase inhibitor. Zomepirac sodium salt blocks prostaglandin synthesis and inhibits Collagen (HY-P72147)- or Epinephrine (HY-B0447)-induced platelet aggregation. Zomepirac sodium salt can be used for the research of postoperative pain and osteoarthritis .
|
-
- HY-B0890A
-
|
McN-2783-21-98 free acid
|
PGE synthase
|
Neurological Disease
Inflammation/Immunology
|
|
Zomepirac (McN-2783-21-98 free acid) is an orally active prostaglandin synthetase inhibitor. Zomepirac blocks prostaglandin synthesis and inhibits Collagen (HY-P72147)- or Epinephrine (HY-B0447)-induced platelet aggregation. Zomepirac can be used for the research of postoperative pain and osteoarthritis .
|
-
- HY-B0890
-
|
McN-2783-21-98
|
PGE synthase
|
Neurological Disease
Inflammation/Immunology
|
|
Zomepirac sodium salt (McN-2783-21-98) is an orally active prostaglandin synthetase inhibitor. Zomepirac sodium salt blocks prostaglandin synthesis and inhibits Collagen (HY-P72147)- or Epinephrine (HY-B0447)-induced platelet aggregation. Zomepirac sodium salt can be used for the research of postoperative pain and osteoarthritis .
|
-
- HY-125954S
-
|
UDP-α-D-glucuronic acid-13C,15N2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Uridine diphosphate glucuronic acid- 13C, 15N2 (UDP-α-D-glucuronic acid- 13C, 15N2) is the 13C- and 15N-labeled Uridine diphosphate glucuronic acid (HY-125954). Uridine diphosphate glucuronic acid ammonium (UDP-α-D-glucuronic acid ammonium) is a glucuronic acid donor. Uridine diphosphate glucuronic acid ammonium transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid ammonium serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid .
|
-
- HY-41982
-
|
D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone
|
Environmental Pollutants
Endogenous Metabolite
Drug Derivative
|
Cardiovascular Disease
Metabolic Disease
|
|
D-Glucuronic acid lactone (D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone) is an endogenous metabolite and a glucuronic acid derivative. D-Glucuronic acid lactone serves as a starting reagent for the synthesis of 2,3,4-tris (tert-butyldimethylsilyl) glucuronic acid trichloroethyl ester, which is used to prepare 1-O-acyl glucuronic acids for the anti-inflammatory agent mL-3000 (HY-B1452), synthesize optically active glucuronic acids, and produce long-chain alkyl glucuronides. D-Glucuronic acid lactone shows potential for use in studies of reversible cerebral vasoconstriction syndrome (RCVS) .
|
-
- HY-N11424
-
|
|
Drug Metabolite
Glycosyltransferase
|
Metabolic Disease
|
|
Bilirubin diglucuronide is a bilirubin glycoside conjugate with a 1-O-acyl β-D-glucuronide structure. Bilirubin diglucuronide is the major conjugated bilirubin (HY-N0323) and predominant pigment excreted in the bile of adult humans, rats, dogs and cats. Bilirubin diglucuronide is mainly synthesized via UDP-glucuronosyltransferase-mediated transfer of glucuronic acid from UDP-glucuronic acid to bilirubin monoglucuronide, or via enzymatic disproportionation of two moles of bilirubin monoglucuronide (predominantly producing the IXα configuration). In addition, Bilirubin diglucuronide can also be synthesized from bilirubin or its monoglucuronide in a UDP-glucuronic acid-dependent manner. Pretreatment with phenobarbital significantly enhances the formation process of Bilirubin diglucuronide .
|
-
- HY-177434
-
|
Precem-TcT; M 9140
|
Antibody-Drug Conjugates (ADCs)
Transmembrane Glycoprotein
Topoisomerase
|
Cancer
|
|
Precemtabart tocentecan (Precem-TcT; M 9140) is an anti-CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) antibody-drug conjugate (ADC). Precemtabart tocentecan consists of a tumor-specific anti-CEACAM5 monoclonal antibody Precemtabart (HY-P990940), a highly hydrophilic and stable cleavable β-glucuronide linker, and a topoisomerase 1 inhibitor payload Exatecan (HY-13631), and the drug-linker conjugate for ADC is Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179). Precemtabart tocentecan inhibits the growth of CEACAM5-positive cancer cells. Precemtabart tocentecan exhibits significant antitumor activity in CEACAM5-expressing xenograft models. Precemtabart tocentecan can be used for the study of CEACAM5-expressing advanced solid tumors, especially mCRC .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D0935A
-
|
MUG
|
Fluorescent Dyes
|
|
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .
|
-
- HY-177434
-
|
Precem-TcT; M 9140
|
Fluorescent Dyes
|
|
Precemtabart tocentecan (Precem-TcT; M 9140) is an anti-CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) antibody-drug conjugate (ADC). Precemtabart tocentecan consists of a tumor-specific anti-CEACAM5 monoclonal antibody Precemtabart (HY-P990940), a highly hydrophilic and stable cleavable β-glucuronide linker, and a topoisomerase 1 inhibitor payload Exatecan (HY-13631), and the drug-linker conjugate for ADC is Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179). Precemtabart tocentecan inhibits the growth of CEACAM5-positive cancer cells. Precemtabart tocentecan exhibits significant antitumor activity in CEACAM5-expressing xenograft models. Precemtabart tocentecan can be used for the study of CEACAM5-expressing advanced solid tumors, especially mCRC .
|
-
- HY-158109
-
|
|
Fluorescent Dyes
|
|
M3554 is an anti-GD2 antibody-drug conjugate (ADC) based on the humanized anti-GD2 antibody. M3554 consists of the humanized monoclonal antibody hu14.18 (K322A) (HY-P991040) linked to a topoisomerase 1 inhibitor Exatecan (HY-13631) via a cleavable β-glucuronide linker. M3554 can be used for the study of neuroblastoma, osteosarcoma or glioma .
|
-
- HY-D1707
-
|
|
Fluorescent Dyes
|
|
FDGlcU can be used as a fluorescent probe for non-invasively image with a high level of fluorescent activity. FDGlcU is non-fluorescent when the fluorescein is conjugated with two mono-glucuronides (Ex/Em=480/514 nm) .
|
-
- HY-D1460
-
|
|
Fluorescent Dyes
|
|
Fluorescein Di-β-D-Glucuronide is an orally active fluorescent probe substrate and an indicator of β-glucuronidase (βG) activity in intestinal bacteria. Fluorescein Di-β-D-Glucuronide can be used for non-invasive time-lapse optical imaging of βG activity in intestinal bacteria in nude mice. Fluorescein Di-β-D-Glucuronide supports the quantitative analysis of bacterial βG enzyme activity and inhibition .
|
-
- HY-W750220
-
| Cat. No. |
Product Name |
Type |
-
- HY-137959
-
|
|
Biochemical Assay Reagents
|
|
Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions .
|
-
- HY-125954A
-
|
UDP-α-D-glucuronic acid ammonium
|
Biochemical Assay Reagents
|
|
Uridine diphosphate glucuronic acid ammonium (UDP-α-D-glucuronic acid ammonium) is a glucuronic acid donor. Uridine diphosphate glucuronic acid ammonium transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid ammonium serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid .
|
-
- HY-D0935
-
|
|
Biochemical Assay Reagents
|
|
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .
|
-
- HY-137869
-
|
5-Bromo-6-chloro-3-indolyl β-D-Glucuronide cyclohexylammonium
|
Biochemical Assay Reagents
|
|
Magenta-β-D-GlcA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W699225
-
-
- HY-137833
-
|
Naphthol AS-BI β-D-Glucuronide
|
Biochemical Assay Reagents
|
|
Naphthol AS-BI β-D-Glucuronide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W039885
-
-
- HY-137781
-
|
Phenyl-Beta-D-Glucuronide
|
Biochemical Assay Reagents
|
|
Phenyl-β-D-glucuronide (Phenyl-Beta-D-Glucuronide) is a biochemical assay reagent.
|
-
- HY-W699926
-
|
(R)-Naproxen-β-D-Glucuronide
|
Biochemical Assay Reagents
|
|
(R)-Naproxen acyl-β-D-glucuronide ((R)-Naproxen-β-D-glucuronide) is a compound metabolite with anti-inflammatory activity. (R)-Naproxen acyl-β-D-glucuronide can serve as a sensitive fluorescent substrate for proglutamyl peptidase 1, which produces a blue reaction after cleavage.
|
-
- HY-W854392
-
|
|
Biochemical Assay Reagents
|
|
3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) is a chromogenic substrate with biological activity for enzyme activity detection. 3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) can be used to evaluate biological reactions associated with glycosidases. 3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) shows a wide range of application potentials in compound discovery and biomedical research.
|
-
- HY-137426
-
-
- HY-W338768
-
-
- HY-W354066
-
|
|
Biochemical Assay Reagents
|
|
Biochanin A-7-O-β-D-glucuronide is a glucuronidated derivative of phytoestrogen, which has the ability to study the metabolic activity of phytoestrogen in the ecosystem. Biochanin A-7-O-β-D-glucuronide plays an important role in ecological research. Biochanin A-7-O-β-D-glucuronide is used to explore the interaction between plants and the environment.
|
-
- HY-W567866
-
-
- HY-W742736
-
-
- HY-137783
-
-
- HY-W787458
-
-
- HY-W416222
-
|
|
Biochemical Assay Reagents
|
|
Methyl β-D-glucuronide sodium is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-W700451
-
-
- HY-W145619
-
|
|
Biochemical Assay Reagents
|
|
4-Nitrophenyl α-D-Glucuronide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W708061
-
|
|
Biochemical Assay Reagents
|
|
Benoxaprofen glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
|
-
- HY-162817
-
|
|
Biochemical Assay Reagents
|
|
N′-Nitrosonornicotine N-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W399188
-
-
- HY-W354925
-
|
|
Biochemical Assay Reagents
|
|
Lumiracoxib acyl-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W740133
-
|
|
Biochemical Assay Reagents
|
|
Rhein 8-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W740685
-
|
|
Biochemical Assay Reagents
|
|
Deferasirox acyl-β-D-glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
|
-
- HY-W328438
-
|
|
Biochemical Assay Reagents
|
|
Mefenamic acyl-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W700345
-
|
|
Biochemical Assay Reagents
|
|
Desmethyl ranolazine β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-Glycan recognition and the role of glycans in biological systems. This field is closely related to basic research, biomedicine and biotechnology.
|
-
- HY-W340093
-
|
|
Biochemical Assay Reagents
|
|
Probenecid acyl β-D-glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
|
-
- HY-137194
-
|
|
Biochemical Assay Reagents
|
|
Ethynyl estradiol 3-bD-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-Glycan recognition and the role of glycans in biological systems. This field is closely related to basic research, biomedicine and biotechnology.
|
-
- HY-W778538
-
|
ADG
|
Biochemical Assay Reagents
|
|
Alphadolone 21-β-D-glucuronide (ADG) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W416264
-
|
|
Biochemical Assay Reagents
|
|
2-Aminophenyl β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W587441
-
|
|
Biochemical Assay Reagents
|
|
Chloramphenicol 3-O-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W780205
-
|
|
Biochemical Assay Reagents
|
|
(Rac)-Hesperetin 3'-O-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W740051
-
|
|
Biochemical Assay Reagents
|
|
13-cis Retinoyl β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W791535
-
|
|
Biochemical Assay Reagents
|
|
4-Hydroxy propofol 1-O-β-D-glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
|
-
- HY-W700218
-
|
|
Biochemical Assay Reagents
|
|
4-Hydroxy propofol 4-O-β-D-Glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
|
-
- HY-W561088
-
-
- HY-W039893
-
-
- HY-W145687
-
|
Diosgenin-3-O-Β-D-Glucuronide
|
Biochemical Assay Reagents
|
|
Diosgenin-3-O-β-D-sodium glucuronide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W568899
-
-
- HY-W039888
-
-
- HY-W777241
-
|
|
Biochemical Assay Reagents
|
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Dexamethasone β-D-glucuronide (sodium) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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- HY-167818
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Biochemical Assay Reagents
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Bazedoxifene bis-β-D-glucuronide is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
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- HY-W777656
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Biochemical Assay Reagents
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Varenicline crbamoyl β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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- HY-W777292
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Biochemical Assay Reagents
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Ethynyl estradiol 17-β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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- HY-N0197
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-
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- HY-13930
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-
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- HY-N6612
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-
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- HY-N2481
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- HY-N1463
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Luteolin 7-Glucuronide
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Structural Classification
Flavonoids
other families
Classification of Application Fields
Flavones
Other Diseases
Phenols
Polyphenols
Plants
Disease Research Fields
Source Classification
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MMP
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Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .
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-
-
- HY-W040047
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-
-
- HY-N1454
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-
-
- HY-41982
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-
-
- HY-113093
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-
-
- HY-N7176
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-
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- HY-N2376
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-
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- HY-113083
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-
-
- HY-N6612R
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-
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- HY-113157
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-
-
- HY-W353102
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-
-
- HY-129987
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-
-
- HY-N4099
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-
-
- HY-125954
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UDP-α-D-glucuronic acid
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Human Gut Microbiota Metabolites
Microorganisms
Endogenous metabolite
Source Classification
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Endogenous Metabolite
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Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a glucuronic acid donor. Uridine diphosphate glucuronic acid transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid .
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-
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- HY-W345885
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-
-
- HY-126848
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- HY-N6879
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- HY-N11424
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Structural Classification
Natural Products
Endogenous metabolite
Source Classification
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Drug Metabolite
Glycosyltransferase
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Bilirubin diglucuronide is a bilirubin glycoside conjugate with a 1-O-acyl β-D-glucuronide structure. Bilirubin diglucuronide is the major conjugated bilirubin (HY-N0323) and predominant pigment excreted in the bile of adult humans, rats, dogs and cats. Bilirubin diglucuronide is mainly synthesized via UDP-glucuronosyltransferase-mediated transfer of glucuronic acid from UDP-glucuronic acid to bilirubin monoglucuronide, or via enzymatic disproportionation of two moles of bilirubin monoglucuronide (predominantly producing the IXα configuration). In addition, Bilirubin diglucuronide can also be synthesized from bilirubin or its monoglucuronide in a UDP-glucuronic acid-dependent manner. Pretreatment with phenobarbital significantly enhances the formation process of Bilirubin diglucuronide .
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- HY-N7390
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- HY-N1439
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- HY-125954A
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- HY-W778608
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- HY-W416250
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- HY-N6851
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- HY-N0197R
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- HY-113095
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- HY-N11429
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- HY-N12394
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- HY-N9970
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-
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- HY-118774
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- HY-N10647
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- HY-126423
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- HY-N1454R
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- HY-N11026
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- HY-113245
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- HY-N7035
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- HY-N10799
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- HY-N6612A
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- HY-N1463R
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Luteolin 7-Glucuronide (Standard)
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Structural Classification
Flavonoids
other families
Flavones
Phenols
Polyphenols
Plants
Source Classification
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Reference Standards
MMP
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Luteolin 7-O-glucuronide (Standard) is the analytical standard of Luteolin 7-O-glucuronide. This product is intended for research and analytical applications. Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .
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- HY-N2481R
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Oroxyloside (Standard); Oroxylin A-7-O-β-D-Glucuronide (Standard)
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Monophenols
Flavonoids
Flavones
Labiatae
Phenols
Plants
Medicago truncatula Gaertn.
Source Classification
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Reference Standards
Prolyl Endopeptidase (PREP)
Drug Metabolite
JNK
PPAR
NF-κB
Interleukin Related
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Oroxylin A-7-O-glucuronide (Standard) is the analytical standard of Oroxylin A-7-O-glucuronide (HY-N2481). This product is intended for research and analytical applications. Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .
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- HY-N13388
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-
-
- HY-N15706
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Flavonoids
Astragalus laxmannii Jacq.
Flavones
Labiatae
Plants
Source Classification
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LDLR
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Luteolin-7-O-β-D-glucuronide methyl ester is a flavonoid with antioxidative activity. Luteolin-7-O-β-D-glucuronide methyl ester exhibits potent antioxidative activity with an IC50 of 3.05 μg/mL in the NBT superoxide scavenging assay. Luteolin-7-O-β-D-glucuronide methyl ester inhibits LDL oxidation induced by Cu 2+ with the IC50 value is 71.13 μg/mL .
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-
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- HY-N17672
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- HY-111812
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- HY-113105
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- HY-N12469
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- HY-113169
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- HY-N12028
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- HY-167859
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- HY-135956
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- HY-N8841
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- HY-113083R
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- HY-N2376R
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- HY-118774R
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- HY-N4099R
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- HY-N6879R
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- HY-N12025
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- HY-N8578
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- HY-13930R
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- HY-N12588
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- HY-N12793
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-
- HY-N8029
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- HY-N12299
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-
- HY-126194
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-
- HY-N7176R
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Kaempferol-3-Glucuronide (Standard); Kaempferol-3-O-Glucuronide (Standard)
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Flavonols
Structural Classification
Flavonoids
Microorganisms
other families
Phenols
Polyphenols
Plants
Source Classification
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Reference Standards
Interleukin Related
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Prosulfocarb (Standard) is the analytical standard of Prosulfocarb. This product is intended for research and analytical applications. Prosulfocarb is a herbicide with a rapidly growing use trend. Prosulfocarb is used in winter cereals to help address the problem of increasing biotic resistance of weeds to certain pesticides. Environmental and food effects of prosulfocarb have been observed, and its transfer pattern from target crops to non-target areas has been studied. The volatility effect of prosulfocarb is an important factor explaining the inefficiency of isolated area contamination and marginal protection against residue spread .
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- HY-W778608R
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Quercetin 7-O-β-Glucuronide (Standard)
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Flavonols
Flavonoids
Pedaliaceae
Plants
Uncarina grandidieri (Baill.) Ihlenf. & Straka
Source Classification
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Drug Metabolite
Reference Standards
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Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .
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- HY-N18207
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- HY-N13065
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- HY-180680
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- HY-180679
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- HY-N18372
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-
- HY-N17334
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- HY-N19800
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|
Structural Classification
Flavonols
Flavonoids
Endogenous metabolite
Source Classification
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Drug Metabolite
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Anhydroicaritin-3,7-di-O-glucuronide is a diglucuronide metabolite of icaritin. Anhydroicaritin-3,7-di-O-glucuronide is also a conjugated metabolite derived from prenylated flavonoids of the genus *Epimedium* in rats. In an in vitro microsomal system, Anhydroicaritin-3,7-di-O-glucuronide is mainly catalyzed by UGT1A1 and UGT1A8. Anhydroicaritin-3,7-di-O-glucuronide is generated via sequential glucuronidation at the 3-OH and 7-OH sites of icaritin, or via further conversion from monoglucuronides of icaritin .
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- HY-N16924
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- HY-W749337
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- HY-W777236
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- HY-W709715
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- HY-N17775
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- HY-113249
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- HY-118724
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-
| Cat. No. |
Product Name |
Chemical Structure |
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- HY-151027S
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Androsterone glucuronide-d4 is the deuterium labeled Androsterone glucuronide .
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- HY-113093S
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Ethyl glucuronide-d5 is the deuterium labeled Ethyl glucuronide (HY-113093) . Ethyl glucuronide is an endogenous metabolite. Ethyl glucuronide is the metabolite of ethanol. Ethyl glucuronide is a biomarker for ethanol exposure that accumulates in hair and reflects the alcohol intake over a time period. Ethyl glucuronide is the agonist for TLR4 .
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- HY-132723AS
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17β-Estradiol-3-β-D-glucuronide-d3 (sodium) is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide .
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- HY-132723S
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17β-Estradiol-3-β-D-glucuronide-d3 is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide .
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- HY-126373S1
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SN-38 glucuronide- 13C6 is the 13C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
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- HY-135391S
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Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity . Ezetimibe is a potent cholesterol absorption inhibitor .
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- HY-136307S
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Tizoxanide-d4 glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum .
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- HY-G0020S1
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Nicotine N-β-D-glucuronide-d3 (Nicotine N-glucuronide-d3) is a deuterium labeled compound.
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- HY-W701013
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Propofol beta-D-glucuronide-d17 is deuterium labeled Propofol beta-D-glucuronide .
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- HY-137083S
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Trifluoperazine N-glucuronide-d3 is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .
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- HY-125954S
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Uridine diphosphate glucuronic acid- 13C, 15N2 (UDP-α-D-glucuronic acid- 13C, 15N2) is the 13C- and 15N-labeled Uridine diphosphate glucuronic acid (HY-125954). Uridine diphosphate glucuronic acid ammonium (UDP-α-D-glucuronic acid ammonium) is a glucuronic acid donor. Uridine diphosphate glucuronic acid ammonium transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid ammonium serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid .
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- HY-141914S
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Cortisol-21-glucuronide-d4 (sodium) is the deuterium labeled Cortisol-21-glucuronide .
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- HY-W040047S
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Pregnanediol 3-glucuronide is the main end-metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is a metabolite of Progesterone formed by hydroxylation and glucuronidation in the liver, with high hydrophilicity and easy excretion through urine. Pregnanediol 3-glucuronide excretion rate of ≥ 9 μmol/24 h can serve as biochemical evidence of ovulation. Pregnanediol 3-glucuronide reflects the quality of the luteal phase, and a level of < 7 μmol/24 h may indicate anovulation or luteal insufficiency. Pregnanediol 3-glucuronide holds significant importance in monitoring female reproductive health, assessing pregnancy, and diagnosing endocrine disorders.
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- HY-143915S
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Amitriptyline-N-glucuronide-d3 is the deuterium labeled Amitriptyline-N-glucuronide .
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- HY-137522S
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Zidovudine O-β-D-glucuronide-d3 sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .
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- HY-142266S
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Retigabine N-β-D-glucuronide-d4 is the deuterium labeled Retigabine N-β-D-glucuronide .
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- HY-W746747
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(R)-Nicotine-d3 N-β-D-Glucuronide is the deuterium labeled (R)-Nicotine N-β-D-Glucuronide.
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- HY-143957S
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Fenretinide glucuronide-d4 is the deuterium labeled Fenretinide glucuronide .
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- HY-154762S
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Acetaminophen glucuronide-d4 is deuterated labeled Acetaminophen glucuronide.
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- HY-125370S
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Phenylephrine glucuronide-d3 is deuterium labeled Phenylephrine glucuronide.
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- HY-144247S
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Edaravone glucuronide-d5 (sodium) is the deuterium labeled Edaravone glucuronide sodium .
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- HY-143927S
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Belinostat glucuronide-d5 is the deuterium labeled Belinostat glucuronide .
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- HY-143911S
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Acetaminophen glucuronide-d3 is the deuterium labeled Acetaminophen glucuronide .
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- HY-144201S
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Serotonin glucuronide-d4 is the deuterium labeled Serotonin glucuronide .
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- HY-151706S
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Temazepam glucuronide-d5 is a deuterium labeled Temazepam glucuronide .
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- HY-137301S
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Mycophenolic acid glucuronide-d3 is the deuterium labeled Mycophenolic acid glucuronide .
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- HY-W767389
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Androsterone glucuronide-d5 is the deuterium labeled Androsterone glucuronide (HY-113104).
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- HY-143929S
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Bazedoxifene-5-glucuronide-d4 is the deuterium labeled Bazedoxifene-5-glucuronide .
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- HY-W016034S
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Acetaminophen glucuronide-d3 sodium salt is the deuterium labeled Acetaminophen glucuronide sodium salt.
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- HY-135582S
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Raloxifene 4'-glucuronide-d4 is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
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- HY-144166S
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Silodosin glucuronide-d4 (lithium) is the deuterium labeled Silodosin glucuronide lithium .
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- HY-132618S
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N-Acetyltyramine Glucuronide-d3 is the deuterium labeled N-Acetyltyramine Glucuronide .
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- HY-135582S1
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Raloxifene 4'-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
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- HY-135581S1
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Raloxifene 6-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
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- HY-W726630
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Tizoxanide-d4 glucuronide disodium is the deuterium labeled Tizoxanide glucuronide disodium.
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- HY-W766163
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7-Hydroxy coumarin glucuronide-d5 sodium is the deuterium labeled 7-Hydroxy coumarin glucuronide sodium (HY-120201). 7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin .
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- HY-113018S
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Ibuprofen acyl-β-D-glucuronide-d3 is the deuterium labeled Ibuprofen acyl-β-D-glucuronide .
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- HY-113104S
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Androsterone glucuronide-d4 (sodium) (ADT-G-d4 sodium) is the deuterium labeled Androsterone glucuronide sodium .
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- HY-W653919
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SN-38 glucuronide-d3 is deuterium labeled SN-38 glucuronide. SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
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- HY-150159S
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Cotinine-d3 N-β-D-Glucuronide is the deuterium labeled Cotinine N-β-D-Glucuronide (HY-W588194). Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function .
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- HY-W588194S
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(±)-Cotinine-N-β-Glucuronide-d3 is deuterated labeled (±)-Cotinine-N-β-Glucuronide.
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- HY-143953S
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Estrone ?-D-Glucuronide-d4 (lithium) is the deuterium labeled Estrone ?-D-Glucuronide .
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- HY-W008917S1
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Estrone β-D-glucuronide-d4 (sodium) is deuterium labeled Estrone beta-D-glucuronide sodium salt.
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- HY-118774S
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Propofol-d17 β-D-glucuronide is the deuterium labeled Propofol β-D-glucuronide .
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- HY-142598S
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Serotonin-d4 β-D-glucuronide is the deuterium labeled Serotonin β-D-glucuronide .
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- HY-132480S
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Ciclopirox-d11 β-D-Glucuronide is the deuterium labeled Ciclopirox β-D-Glucuronide .
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- HY-W777677
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Bisphenol b-D-glucuronide A-d6 is the deuterium labeled Bisphenol A-β-D-glucuronide (HY-W585982). Bisphenol A-β-D-glucuronide is an inactive metabolite of the plasticizer Bisphenol A (HY-18260) .
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- HY-W769286
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Valproic acid β-D-glucuronide-d15 is the deuterium labeled Valproic acid β-D-glucuronide (HY-W400496). Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .
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- HY-167814S
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Deferiprone-d3 3-O-Beta-D-Glucuronide Sodium Salt is the deuterium labeled Deferiprone O-β-D-glucuronide (HY-160078). Deferiprone O-β-D-glucuronide is a novel orally active iron chelator. Deferiprone O-β-D-glucuronide shows the capability of reducing the iron burden in patients with β-thalassemia .
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- HY-141903S
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Taurocholic acid-3-o-glucuronide-d4 is the deuterium labeled Taurocholic acid-3-o-glucuronide .
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- HY-W766293
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1-Hydroxypyrene β-D-glucuronide-d9 is the deuterium labeled 1-Hydroxypyrene β-D-glucuronide (HY-W699225). 1-Hydroxypyrene β-D-glucuronide is a biochemical reagent.
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- HY-W756134
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Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d5 sodium is the deuterium labeled Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium. Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium is a metabolite of Chenodeoxycholic Acid (HY-76847) .
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- HY-W766332
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7-Hydroxy coumarin glucuronide sodium- 13C6 is the 13C-labeled 7-Hydroxy coumarin glucuronide sodium (HY-120201). 7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin .
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- HY-W752886
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Estradiol 3-d3 (β-D-Glucuronide) sodium is the deuterium labeled Estradiol 3-(β-D-Glucuronide) sodium (HY-N7755). Estradiol 3-(β-D-Glucuronide) sodium is the glucuronic acid derivative of estradiol (HY-B0141). Estradiol 3-(β-D-Glucuronide) sodium is radiolabeled for use in tumor imaging and biodistribution studies .
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- HY-122813S1
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Dabigatran acyl-β-D-glucuronide-d3 (TFA) is the deuterium labeled Dabigatran Acyl-β-D-Glucuronide trifluoroacetate .
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- HY-W700378
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Valproic acid β-D-glucuronide-d6-1 is the deuterium labeled Valproic acid β-D-glucuronide (HY-W400496). Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .
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- HY-W744370
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Raloxifene 6-β-D-glucuronide-d4 lithium is the deuterium labeled Raloxifene 6-β-D-glucuronide lithium.
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- HY-142581S
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1-Naphthol β-D-glucuronide-d7 (sodium) is the deuterium labeled 1-Naphthol β-D-glucuronide sodium .
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- HY-141945S
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Taurochenodeoxycholic acid-3-o-glucuronide-d4 (disodium) is the deuterium labeled Taurochenodeoxycholic acid-3-o-glucuronide .
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- HY-154772S
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trans-3’-Hydroxycotinine-O-β-glucuronide-d3 is deuterated labeled trans-3’-Hydroxycotinine-O-β-glucuronide.
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- HY-W585982S
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Bisphenol A β-D-Glucuronide- 13C12 is the 13C labeled isotope of Bisphenol A β-D-Glucuronide (HY-W585982). Bisphenol A-β-D-glucuronide is an inactive metabolite of the plasticizer Bisphenol A (HY-18260) .
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- HY-142119S
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5-Hydroxy tryptophol β-D-glucuronide-d4 is the deuterium labeled 5-Hydroxy tryptophol β-D-glucuronide .
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- HY-137912S1
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Resveratrol-3-O-beta-D-glucuronide- 13C6 is deuterium labeled trans-Resveratrol-3-O-β-D-Glucuronide.
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- HY-120201S
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7-Hydroxy Coumarin-d5 β-D-glucuronide (sodium) is the deuterium labeled 7-Hydroxy Coumarin β-D-glucuronide sodium .
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- HY-W699866
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Gemfibrozil 1-O-β-glucuronide-d6 is the deuterium labeled Gemfibrozil 1-O-β-glucuronide (HY-129993). Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM .
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- HY-150985S
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2,2'-Dichloro bisphenol a mono-D-glucuronide-d12 is the deuterium labeled 2,2'-Dichloro bisphenol a mono-D-glucuronide .
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- HY-142279S
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17β-Estradiol 17-acetate 3-β-D-glucuronide-d3 is the deuterium labeled 17β-Estradiol 17-acetate 3-β-D-glucuronide .
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- HY-169528S
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Telmisartan-d3 Acyl-Beta-D-glucuronide is the deuterium labeled WAY-329341 (HY-169528).
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- HY-118634S
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trans-Resveratrol-4'-O-D-Glucuronide-d4 (R-4G-d4) is deuterium labeled trans-Resveratrol-4'-O-D-Glucuronide.
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- HY-154774S
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Tetrahydro-11-deoxy-Cortisol-d5-21-O-β-Glucuronide is deuterated labeled Tetrahydro-11-deoxy-Cortisol.
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- HY-167927S
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Mycophenolic Acid-d3 Acyl-Beta-D-glucuronide is the deuterium labeled Mefuparib (HY-167927). Mefuparib (CVL218) is a poly ADP-ribose polymerase (PARP) inhibitor used in cancer research that exhibits potent brain penetration due to its high protein binding.
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- HY-167926S
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Mycophenolic Acid-d3 beta-D-Glucuronide is the deuterium labeled 3-Bromo-4,5-dihydroxybenzoic acid methyl ester (HY-167926). 3-Bromo-4,5-dihydroxybenzoic acid methyl ester is a marine-derived natural product known for its biological activity, specifically showcasing antioxidant properties and potential therapeutic applications against oxidative stress-related diseases.
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- HY-W767542
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Dihydro Isoferulic Acid-d3 3-O-b-D-Glucuronide is the deuterium labeled (2S,3S,4S,5R,6S)-6-(5-(2-Carboxyethyl)-2-methoxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid (HY-W703563).
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- HY-158238S
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Silodosin glucoronide-d4 is deuterium labeled Silodosin glucoronide .
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- HY-W008125S
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Acetobromo-a-D-glucuronic acid- 13C6 methyl ester (Methyl acetobromo-α-D-glucuronate- 13C6 methyl ester) is 13C labeled Acetobromo-α-D-glucuronic acid methyl ester, 98% (HY-W008125). Acetobromo-α-D-glucuronic acid methyl ester, 98% is an intermediate. Acetobromo-α-D-glucuronic acid methyl ester, 98% can be used to synthesize HMR1098-S-Glucuronide Methyl Ester. HMR1098 is a novel KATP blocker that is metabolized to S-glucuronide in rat and dog bile. Acetobromo-α-D-glucuronic acid methyl ester, 98% can be used in the research of sudden cardiac death .
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- HY-B0947S1
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Sulfanitran- 13C6 is the 13C labeled Sulfanitran. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG).
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- HY-B0947S
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Sulfanitran-d4 is the deuterium labeled Sulfanitran. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG) .
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- HY-W803819S
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Propranolol glucuronide-d6 is the deuterium labeled Propranolol glucuronide.
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- HY-W701234
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Propofol Glucuronide-d17 Methyl Ester is the deuterium labeled Propofol Glucuronide Methyl Ester.
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- HY-W701833S
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Ambrisentan acyl-β-D-glucuronide-d10 is the deuterium labeled Ambrisentan acyl-β-D-glucuronide.
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- HY-137522AS1
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Zidovudine Glucuronide- 13C6 (3'-Azido-3'-deoxythymidine β-D-glucuronide- 13C6) is 13C labeled Zidovudine O-β-D-glucuronide. Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .
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- HY-142258S
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Diosmetin 3-O-β-D-glucuronide-d3 is the deuterium labeled Diosmetin 3-O-β-D-glucuronide .
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- HY-122813S3
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Dabigatran acyl-β-D-glucuronide- 13C6 is the 13C-labeled Dabigatran acyl-β-D-glucuronide.
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- HY-W768439
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Diosmetin 7-O-β-D-Glucuronide-d3 Sodium Salt is the deuterium labeled Diosmetin 7-O-β-D-Glucuronide Sodium Salt.
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- HY-W770285
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Bisphenol A bis-(β-D-glucuronide)- 13C12 sodium is the 13C-labeled Bisphenol A bis-(β-D-glucuronide).
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- HY-W705647
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rac Erythro Dihydrobupropion Beta-D-Glucuronide-d9 is the deuterium labeled rac Erythro Dihydrobupropion Beta-D-Glucuronide.
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- HY-W740902
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(E,Z)-Tamoxifen-N-β-D-glucuronide-d5 is the deuterium labeled (E,Z)-Tamoxifen-N-β-D-glucuronide.
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- HY-W765751
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trans-3'-Hydroxy Cotinine-d3 N-b-D-Glucuronide is the deuterium labeled trans-3'-Hydroxy Cotinine N-b-D-Glucuronide.
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- HY-W759947
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24-Nor ursodeoxycholic acid-d5 acyl-b-D-glucuronide is the deuterium labeled 24-Nor ursodeoxycholic acid-d5 acyl-b-D-glucuronide (HY-W759947) .
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- HY-W767663
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17b-Hydroxy Exemestane-d3 17-O-b-D-Glucuronide is the deuterium labeled 17b-Hydroxy Exemestane 17-O-b-D-Glucuronide.
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| Cat. No. |
Product Name |
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Classification |
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- HY-137522
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3'-Azido-3'-deoxythymidine β-D-Glucuronide sodium
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Azide
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Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .
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