3 Results for "

HMC-1 human mast cells

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "HMC-1 human mast cells" in MCE Product Catalog:

Terreic acid
Terreic acid
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Cat. No.: HY-110013
CAS No.: 121-40-4
Category:  

Quinones Microorganisms Benzene Quinones

Target:  

Btk Antibiotic

Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM .
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2′,3′-Dihydroxypuberulin
2′,3′-Dihydroxypuberulin
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Cat. No.: HY-N19733
CAS No.: 79147-77-6
Category:  

Asteraceae Coumarins Pterocaulon balansae Chodat Phenylpropanoids Plants

Target:  

Fc Receptor (FcR)

2′,3′-Dihydroxypuberulin is a naturally derived inhibitor of the FcεRI β-chain with FcεRI expression inhibitory activity in mast cells. 2′,3′-Dihydroxypuberulin suppresses the mRNA level of the FcεRI β-chain, blocks the assembly of the FcεRI tetramer, and reduces the cell surface expression level of FcεRI. 2′,3′-Dihydroxypuberulin can be used in studies related to type I allergic diseases .
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Butrin
Butrin
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Cat. No.: HY-N17821
CAS No.: 492-13-7
Category:  

Flavonoids Leguminosae Flavones Plants Butea monosperma Kuntze

Target:  

Sirtuin Aurora Kinase Akt GSK-3 β-catenin TGF-β Receptor Apoptosis Reactive Oxygen Species (ROS) Wnt NF-κB TNF Receptor Interleukin Related IKK

Butrin is a compound found in Butea monosperma flowers. Butrin reduces expression of SIRT1, AURKB, cyclin D1, pAKT, GSK-3β, β-catenin, and TGF-3β expression, enhances apoptosis and ROS production in cancer cells. Butrin downregulates Wnt and NF-κB signaling, mitigates oxidative stress, reduces proinflammatory cytokine (TNF-α, IL-6 and IL-8) production and suppresses neuroinflammation. Butrin inhibits IKK enzyme activity. Butrin can be used for the researches of colorectal cancer, Alzheimer’s disease, and rheumatoid arthritis .
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