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Cat. No.: HY-N19733

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2′,3′-Dihydroxypuberulin

2′,3′-Dihydroxypuberulin is a naturally derived inhibitor of the FcεRI β-chain with FcεRI expression inhibitory activity in mast cells. 2′,3′-Dihydroxypuberulin suppresses the mRNA level of the FcεRI β-chain, blocks the assembly of the FcεRI tetramer, and reduces the cell surface expression level of FcεRI. 2′,3′-Dihydroxypuberulin can be used in studies related to type I allergic diseases.

For research use only. We do not sell to patients.

CAS No.: 79147-77-6
Formula: C₁₆H₂₀O₇
Molecular Weight:324.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

2′,3′-Dihydroxypuberulin Chemical Structure

CAS No.: 79147-77-6

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

2′,3′-Dihydroxypuberulin (compound 1) (30 μg/mL; 72 h) inhibits FcεRI surface expression on HMC-1 human mast cells by 49.0%, and its absolute configuration does not affect this activity^[2].
2′,3′-Dihydroxypuberulin (50-100 μM; 36 h) significantly down-regulates FcεRI β-chain mRNA expression without altering α-chain or γ-chain mRNA levels in HMC-1 human mast cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[2]

Cell Line:

human mast cell line HMC-1
Concentration:

50, 100 μM
Incubation Time:

36 h
Result:

Suppressed FcεRI β-chain mRNA expression to ~85% of vehicle control levels, while α-chain and γ-chain mRNA levels remained near 95-98% of vehicle control (100 μM).
Suppressed FcεRI β-chain mRNA expression to ~60% of vehicle control, while α-chain and γ-chain mRNA levels remained near 90-95% of vehicle control (50 μM).

Chemical Information

CAS No. 79147-77-6
Molecular Weight 324.33
Formula C₁₆H₂₀O₇
SMILES

COC1=C2C(C=CC(O2)=O)=CC(OC)=C1OCC(O)C(C)(O)C
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Magalhães AF, et al. Coumarins from Pterocaulon balansae and P. lanatum. Phytochemistry, 1981, 20(6):1369-1371.

[2]. Tamura S, et al. Inhibitor for FcεRI expression on mast cell from Verbasucum thapsus L. Bioorganic & medicinal chemistry letters. 2018 Nov 01;28(20):3342-3345. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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