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Isoforms Recommended:	Kinesin-14

Results for "

HSET/KIFC1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Kinesin (3)
By Research Areas:	Cancer (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12241

AZ82 3 Publications Verification	Kinesin	Cancer
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a K_i of 43 nM and an IC₅₀ of 300 nM for KIFC1.

HY-N11128

Solidagonic acid	Kinesin	Cancer
Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds *HSET/KIFC1, restores growth in HSET-overproducing* fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma .

HY-180304

CCT369834	Kinesin	Cancer
CCT369834 is an ATP-competitive HSET inhibitor with an IC₅₀ of 39 nM. CCT369834 is a trans-cyclooctene-tagged probe. CCT369834 and HSET specifically co-localize on mitotic spindles. CCT369834 can be used for the research of cancer .

Solidagonic acid	Structural Classification Terpenoids Diterpenoids Plants Compositae Petalostemun purpureum Source Classification	Kinesin
Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds *HSET/KIFC1, restores growth in HSET-overproducing* fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701380

	KIFC1 Protein, Human KIFC1; Kinesin-like protein KIFC1; Kinesin-like protein 2; Kinesin-related protein HSET	Human	E. coli
	KIFC1 Protein, a minus end-directed microtubule-dependent motor, is crucial for bipolar spindle formation. It also participates in early endocytic vesicle movement, indicating a role in intracellular transport. Additionally, KIFC1 regulates cilium formation and structure, interacting with NUBP1, NUBP2, and PPP1R42, suggesting potential involvement in processes related to nucleotide binding and protein dephosphorylation. KIFC1 Protein, Human is the recombinant human-derived KIFC1 protein, expressed by E. coli , with tag free.

HY-P701381

	KIFC1 Protein, Human (His) KIFC1; Kinesin-like protein KIFC1; Kinesin-like protein 2; Kinesin-related protein HSET	Human	E. coli
	KIFC1 Protein, a minus end-directed microtubule-dependent motor, is crucial for bipolar spindle formation. It also participates in early endocytic vesicle movement, indicating a role in intracellular transport. Additionally, KIFC1 regulates cilium formation and structure, interacting with NUBP1, NUBP2, and PPP1R42, suggesting potential involvement in processes related to nucleotide binding and protein dephosphorylation. KIFC1 Protein, Human (His) is the recombinant human-derived KIFC1 protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2) ICC/IF (2) IP (2) IHC-F (2) WB (2) FC (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

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HY-P83397

	KIFC1 Antibody (YA3142) HSET; KNSL2	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human
	KIFC1 Antibody (YA3142) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KIFC1.

HY-P83397A

	KIFC1 Antibody (YA3142)(PBS only) HSET; KNSL2	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human
	KIFC1 Antibody (YA3142) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KIFC1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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