1 Result for "

HT22 immortalized mouse hippocampal neuronal cells

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "HT22 immortalized mouse hippocampal neuronal cells" in MCE Product Catalog:

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Cat. No.: HY-W009300
CAS No.: 3131-23-5
Synonyms: 4-OHE1
4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .
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