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Results for "

Hederagenin

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

13

Natural
Products

Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-N0256
    Hederagenin
    5+ Cited Publications

    		 COX NF-κB E1/E2/E3 Enzyme Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin can also bind to SKP2, with KD = 67.9 μM. Hederagenin also has preventive potential against alcoholic liver injury .
    Hederagenin
  • HY-N0256R
    Hederagenin (Standard)

    		Reference Standards COX NF-κB Cancer
    Hederagenin (Standard) is the analytical standard of Hederagenin. This product is intended for research and analytical applications. Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .
    Hederagenin (Standard)
  • HY-N2190
    Hederagenin 28-O-beta-D-glucopyranosyl ester

    		Others Cardiovascular Disease Inflammation/Immunology
    Hederagenin 28-O-beta-D-glucopyranosyl ester, a triterpenoid saponin isolated from Ilex cornuta, exhibits protective effects against H2O2-induced myocardial cell injury .
    Hederagenin 28-O-beta-D-glucopyranosyl ester
  • HY-N12017
    3-O-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin28-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester

    		Others Infection Cancer
    3-O-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin28-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester is a hederagenin-type saponin with antitumor and anti-inflammatory properties .
    3-O-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin28-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester
  • HY-144366
    P-gp inhibitor 3

    		P-glycoprotein Cancer
    P-gp inhibitor 3 is an effective P-glycoprotein (P-gp) inhibitor. P-gp inhibitor 3 inhibits the efflux function of P-gp by activating P-gp ATPase. P-gp inhibitor 3 has relatively stronger multidrug resistance (MDR) reversal ability and enhances the anti-tumor activity of Paclitaxel .
    P-gp inhibitor 3
  • HY-113327R
    1,3,7-Trimethyluric acid (Standard)

    		Drug Metabolite Reference Standards Endogenous Metabolite Cancer
    Hederagenin (Standard) is the analytical standard of Hederagenin. This product is intended for research and analytical applications. Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .
    1,3,7-Trimethyluric acid (Standard)
  • HY-N8116
    Leonloside D

    		Others Others
    Leonloside D is a Hederagenin-derived saponin, composed of a molecule of Hederagenin and 1-3 molecules of rhamnose, glucose, or arabinose .
    Leonloside D
  • HY-N17985
    Kalopanaxsaponin H

    		Others Metabolic Disease Inflammation/Immunology
    Kalopanaxsaponin H is an hederagenin glycoside (saponin) with no hypoglycemic activity upon intraperitoneal injection. Kalopanaxsaponin H can be metabolized by human intestinal bacteria into Kalopanaxsaponin I, Kalopanaxsaponin A, hederagenin 3-O-α-L-arabinopyranoside and hederagenin, among which Kalopanaxsaponin I and hederagenin are the main metabolites. Kalopanaxsaponin H is isolated from the stem bark of Kalopanax pictus and is used in diabetes-related research .
    Kalopanaxsaponin H
  • HY-N18022
    Septemloside D

    		Others Others
    Septemloside D (Compound 5) is a hederagenin triterpene saponin found in Kalopanacis Cortex .
    Septemloside D
  • HY-N18269
    3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester

    		Fungal Infection
    3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester is an anti-fungal triterpene saponin. 3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester can be isolated from the aerial parts of Clematis tangutica. 3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester exhibits antifungal activity against fungal strains (P. avellaneum, C. glabrata, S. cerevisiae, T. beigelii), with the strongest activity against S. cerevisiae .
    3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester
  • HY-N17877
    Loniceroside A

    		Drug Derivative Others
    Loniceroside A is a triterpenoid saponin found in the aerial parts of Lonicera japonica .
    Loniceroside A
  • HY-N19880
    Oleanoglycotoxin A

    		Drug Derivative Infection
    Oleanoglycotoxin A is a saponin present in the berries of Phytolacca dodecandra, with antifertility and molluscicidal activities. Oleanoglycotoxin A prevents pregnancy, reduces the number of embryos, inhibits implantation, terminates established pregnancy, and kills Biomphalaria glabrata. Oleanoglycotoxin A can be used in studies related to schistosomiasis .
    Oleanoglycotoxin A
  • HY-N18021
    3-O-[α-L-Arabinopyranosyl]-30-norolean-12,20(29)-dien-28-oic acid

    		Others Others
    3-O-[α-L-Arabinopyranosyl]-30-norolean-12,20(29)-dien-28-oic acid (Compound 1) is a triterpenoid glucoside found in Stauntonia brachyanthera Hand-Mazz .
    3-O-[α-L-Arabinopyranosyl]-30-norolean-12,20(29)-dien-28-oic acid
  • HY-N19715
    Asperosaponin H1

    		Drug Derivative Metabolic Disease Inflammation/Immunology Endocrinology
    Asperosaponin H1 is a triterpenoid saponin (octasaccharide saponin) found in the roots of Dipsacus asperoides C.Y. Cheng et T.M. Ai. Asperosaponin H1 can be used for research on liver and kidney diseases .
    Asperosaponin H1

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