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Cat. No.: HY-N20722

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Pulsatiloside C

Name: Pulsatiloside C
Brand: MedChemExpress
SKU: HY-N20722
Availability: PreOrder

(Synonyms: Cussonoside A)

Pulsatiloside C (Cussonoside A) is an orally active triterpenoid saponin. Pulsatiloside C can be isolated from the roots of Pulsatilla campanella and the stem bark of Cussonia barteri. Pulsatiloside C exhibits sedative activity. Pulsatiloside C reduces locomotor activity in male Swiss albino mice. Pulsatiloside C shows no molluscicidal activity against Biomphalaria glabrata.

For research use only. We do not sell to patients.

CAS No.: 57539-70-5
Formula: C₄₈H₇₈O₁₈
Molecular Weight:943.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pulsatiloside C Chemical Structure

CAS No.: 57539-70-5

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Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	50 μM Compound: 18	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay	[PMID: 31301930]
RAW264.7	IC₅₀	50 μM Compound: 21	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess reagent-based assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess reagent-based assay	[PMID: 30808589]

In Vivo

Pulsatiloside C (1 mg/kg; p.o.; single dose) produces time-dependent sedative activity in male Swiss albino mice by decreasing motility^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino (male, 25-30 g)^[3]
Dosage:

1 mg/kg
Administration:

p.o.; single dose
Result:

Decreased mouse motility with time-dependent effects that increased with time.

Chemical Information

CAS No. 57539-70-5
Molecular Weight 943.13
Formula C₄₈H₇₈O₁₈
SMILES

C(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)(=O)[C@]45[C@](C=6[C@@](C)(CC4)[C@@]7(C)[C@](CC6)([C@]8(C)[C@@](CC7)([C@@](CO)(C)[C@@H](O)CC8)[H])[H])(CC(C)(C)CC5)[H]
Synonyms

Cussonoside A
Structure Classification
- Terpenoids
- Pentacyclic Triterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li X C, et al. Triterpenoid saponins from Pulsatilla campanella[J]. Phytochemistry, 1990, 29(2): 595-599.

[2]. Dubois MA, et al. Cussonosides A and B, two triterpene-saponins from Cussonia barteri. Planta Med. 1986 Apr;(2):80-3. PMID: 3725939.

[3]. Igbe I, et al. Harnessing the medicinal properties of Cussonia barteri Seem.(Araliaceae) in drug development. A review[J]. Herba Polonica, 2018, 64(3).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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