IκB kinase β

Pathways Recommended:	NF-κB

By Targets:	IKK (10) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (2) Apoptosis (2) Bcr-Abl (1) COX (1) ERK (2) Ferroptosis (2) GSK-3 (1) Isotope-Labeled Compounds (1) JNK (2) MEK (2) NF-κB (6) NOD-like Receptor (NLR) (2) p38 MAPK (2) Reactive Oxygen Species (ROS) (2) Reference Standards (2) Src (2) STAT (2) TNF Receptor (2) VEGFR (2) β-catenin (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (9) Metabolic Disease (2) Neurological Disease (3)

Targets Recommended: IKK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0788A

LY2409881 trihydrochloride 4 Publications Verification	IKK Apoptosis	Cancer
LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

HY-N0442

5-O-Methylvisammioside 4'-O-β-D-Glucosyl-5-O-methylvisamminol	NF-κB p38 MAPK JNK Src TNF Receptor NOD-like Receptor (NLR) Amyloid-β MEK ERK Ferroptosis VEGFR Anaplastic lymphoma kinase (ALK) Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the *ROS/NF-κB/NLRP3* pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and *NF-κB* nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting Src kinase and the *NF-κB* pathway .

HY-105661

IMD-0560	IKK	Cancer
IMD-0560 is a novel *IκB kinase* β** inhibitor.

HY-136741

BOT-64 2 Publications Verification	IKK	Inflammation/Immunology
BOT-64 is an *inhibitory κB (IκB) kinase* β (IKKβ) inhibitor with an IC₅₀** of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription .

HY-B0788

LY2409881	IKK	Cancer
LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

HY-P10966A

Tat-IKIP (46-60) TFA	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60) (HY-P10966). Tat-IKIP (46-60) is a *IκB kinase* (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB** targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

HY-107592

ACHP	IKK STAT Apoptosis	Inflammation/Immunology Cancer
ACHP (compound 4j) is a selective and orally active IκB kinase inhibitor with IC₅₀ values of 8.5 nM and 250 nM for IKKβ and IKKα, respectively. ACHP can effectively inhibit the STAT3 signaling pathway and induce cancer cell cycle arrest and apoptosis. ACHP shows anti-inflammatory activity in a mouse ear edema model. ACHP can be used in anti-inflammatory and anti-cancer (such as multiple myeloma and leukemia) studies .

HY-139833

Anti-inflammatory agent 6	NF-κB IKK	Inflammation/Immunology
Anti-inflammatory agent 6 blocks the phosphorylation of *I kappa b kinase* α/β (IKKα/β), IκBα, and nuclear factor kB p65 (NF-κB p65)** which is a key controller of inflammation, thereby showing anti-inflammatory potential.

HY-12383S

Pelubiprofen-13C,d3	Isotope-Labeled Compounds COX	Neurological Disease Inflammation/Immunology
Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

HY-114730

CGA-JK3	IKK	Inflammation/Immunology
CGA-JK3 is CGA-JK3 is an ATP-competitive inhibitor of IKKβ-catalyzed kinase activity. CGA-JK3 inhibits IκBα phosphorylation in LPS (HY-D1056) - induced RAW 264.7 cells .

HY-P10966

Tat-IKIP (46-60)	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) is a *IκB kinase* (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB** targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

HY-N0442R

5-O-Methylvisammioside (Standard) 4'-O-β-D-Glucosyl-5-O-methylvisamminol (Standard)	Reference Standards p38 MAPK Reactive Oxygen Species (ROS) TNF Receptor MEK ERK VEGFR Src Amyloid-β Anaplastic lymphoma kinase (ALK) NF-κB NOD-like Receptor (NLR) JNK Ferroptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) (Standard) is the analytical standard of 5-O-Methylvisammioside. This product is intended for research and analytical applications. 5-O-Methylvisammioside is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the *ROS/NF-κB/NLRP3* pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and *NF-κB* nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting Src kinase and the *NF-κB* pathway.

HY-105661R

IMD-0560 (Standard)	Reference Standards IKK	Cancer
IMD-0560 (Standard) is the analytical standard of IMD-0560 (HY-105661). This product is intended for research and analytical applications. IMD-0560 is a novel IκB kinase β inhibitor.

HY-12292G

IM-12	NF-κB STAT GSK-3 β-catenin Bcr-Abl	Cancer
IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the *NF-κB* and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of *β-catenin* by inhibiting *GSK3β, while also blocking the tyrosine kinase* activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

Cat. No.	Product Name	Type

HY-12292G

IM-12	Fluorescent Dyes
IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the *NF-κB* and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of *β-catenin* by inhibiting *GSK3β, while also blocking the tyrosine kinase* activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

IM-12

Fluorescent Dyes

IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the NF-κB and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of β-catenin by inhibiting GSK3β, while also blocking the tyrosine kinase activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

Cat. No.	Product Name	Type

HY-12292G

IM-12	Biochemical Assay Reagents
IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the *NF-κB* and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of *β-catenin* by inhibiting *GSK3β, while also blocking the tyrosine kinase* activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

IM-12

Biochemical Assay Reagents

IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the NF-κB and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of β-catenin by inhibiting GSK3β, while also blocking the tyrosine kinase activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

Cat. No.	Product Name	Target	Research Area

HY-P10966A

Tat-IKIP (46-60) TFA	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60) (HY-P10966). Tat-IKIP (46-60) is a *IκB kinase* (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB** targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

HY-P10966

Tat-IKIP (46-60)	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) is a *IκB kinase* (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB** targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0442

5-O-Methylvisammioside 4'-O-β-D-Glucosyl-5-O-methylvisamminol	Structural Classification Ophryosporus axilliflorus Hieron. Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Umbelliferae Plants Disease Research Fields Source Classification	NF-κB p38 MAPK JNK Src TNF Receptor NOD-like Receptor (NLR) Amyloid-β MEK ERK Ferroptosis VEGFR Anaplastic lymphoma kinase (ALK) Reactive Oxygen Species (ROS)
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the *ROS/NF-κB/NLRP3* pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and *NF-κB* nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting Src kinase and the *NF-κB* pathway .

HY-N0442R

5-O-Methylvisammioside (Standard) 4'-O-β-D-Glucosyl-5-O-methylvisamminol (Standard)	Structural Classification Ophryosporus axilliflorus Hieron. Ketones, Aldehydes, Acids Umbelliferae Plants Source Classification	Reference Standards p38 MAPK Reactive Oxygen Species (ROS) TNF Receptor MEK ERK VEGFR Src Amyloid-β Anaplastic lymphoma kinase (ALK) NF-κB NOD-like Receptor (NLR) JNK Ferroptosis
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) (Standard) is the analytical standard of 5-O-Methylvisammioside. This product is intended for research and analytical applications. 5-O-Methylvisammioside is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the *ROS/NF-κB/NLRP3* pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and *NF-κB* nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting Src kinase and the *NF-κB* pathway.

Cat. No.	Product Name	Chemical Structure

HY-12383S

Pelubiprofen-13C,d3
Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

Pelubiprofen-13C,d3

Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

Targets Recommended: IKK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12292G

IM-12	NF-κB STAT GSK-3 β-catenin Bcr-Abl	Cancer
IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the *NF-κB* and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of *β-catenin* by inhibiting *GSK3β, while also blocking the tyrosine kinase* activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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IκB kinase β

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Isotope-Labeled Compounds

GMP Molecules

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