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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

Immortalized Mouse Kupffer Cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glycosidase (1) Mitochondrial Metabolism (1) Mitophagy (1) NF-κB (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1)

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N15415

Zaluzanin C	Reactive Oxygen Species (ROS) NF-κB Mitochondrial Metabolism Mitophagy Glycosidase	Infection Metabolic Disease Inflammation/Immunology Cancer
Zaluzanin C is a sesquiterpene lactone and antifungal agent. Zaluzanin C is isolated from the leaves of Vernonia arborea. Zaluzanin C inhibits mtROS-mediated NF-κB activity, as well as LPS- and TNF-α-induced mtROS production. Zaluzanin C alleviates mtROS-mediated mitochondrial dysfunction, enhances Mitophagy, and increases the mRNA levels of fatty acid oxidation genes and mitochondrial biogenesis factors. Zaluzanin C inhibits the formation of advanced glycation end products and α-glucosidase activity. Zaluzanin C improves intracellular lipid accumulation. Zaluzanin C exhibits anti-inflammatory, antioxidant, antifungal, anticancer and pro-osteogenic activities. Zaluzanin C can be used in studies related to non-alcoholic fatty liver disease and obesity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15415

Zaluzanin C	Structural Classification Strobocalyx arborea (Buch.-Ham.) Sch. Bip. Terpenoids Sesquiterpenes Plants Compositae Source Classification	Reactive Oxygen Species (ROS) NF-κB Mitochondrial Metabolism Mitophagy Glycosidase
Zaluzanin C is a sesquiterpene lactone and antifungal agent. Zaluzanin C is isolated from the leaves of Vernonia arborea. Zaluzanin C inhibits mtROS-mediated NF-κB activity, as well as LPS- and TNF-α-induced mtROS production. Zaluzanin C alleviates mtROS-mediated mitochondrial dysfunction, enhances Mitophagy, and increases the mRNA levels of fatty acid oxidation genes and mitochondrial biogenesis factors. Zaluzanin C inhibits the formation of advanced glycation end products and α-glucosidase activity. Zaluzanin C improves intracellular lipid accumulation. Zaluzanin C exhibits anti-inflammatory, antioxidant, antifungal, anticancer and pro-osteogenic activities. Zaluzanin C can be used in studies related to non-alcoholic fatty liver disease and obesity .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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