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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
Influenza A virus PB2 protein
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "Influenza A virus PB2 protein" in MCE Product Catalog:
Cat. No.: HY-N12110
CAS No.: 10371-86-5
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Cat. No.: HY-175559
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TTHP 512 is an influenza A virus (IAV) inhibitor. TTHP 512 demonstrates significant antiviral activity with an IC50 value of 1.46 μM. TTHP 512 inhibits the expression of viral nucleoprotein (NP) and PB2 protein, thereby disrupting the viral replication process. TTHP 512 is promising for research of influenza A virus .
Cat. No.: HY-181691
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JAK2-IN-20 is an orally active dual inhibitor targeting JAK2 kinase (IC50=49.17 nM) and influenza A virus PB2 protein (IC50=3.337 μM, Kd=2.82 μM). JAK2-IN-20 effectively blocks the JAK/STAT signaling pathway by reducing the phosphorylation levels of STAT1 and STAT3, thereby inhibiting viral replication and downregulating the expression of viral NP and PB2 proteins. In addition, JAK2-IN-20 significantly inhibits the mRNA expression of key inflammatory cytokines such as IL-6, TNF-α and IFN-β in inflammation and influenza infection models. JAK2-IN-20 serves as an important tool molecule for the study of influenza A virus infection and related pathologies .
Cat. No.: HY-189357
CAS No.: 3123220-86-7
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PB2-IN-4 is a potent and orally effective PB2 inhibitor with an IC50 of 82 nM. PB2-IN-4 inhibits viral RNA polymerase activity and gene expression by binding to the PB2 protein, and alleviates the host inflammatory response. PB2-IN-4 can be used for research on influenza A virus .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
