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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

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L-02 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Apoptosis (4) Atg8/LC3 (1) Autophagy (1) Bcl-2 Family (1) Caspase (1) DNA/RNA Synthesis (1) Drug Derivative (2) FXR (1) Interleukin Related (1) JNK (1) NF-κB (1) NO Synthase (1) p62 (1) PARP (1) PD-1/PD-L1 (1) Reactive Oxygen Species (ROS) (7) Reference Standards (1) TNF Receptor (1) Virus Protease (3) Wnt (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (1) Metabolic Disease (4)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-N3431

Kaempferol-7-O-rhamnoside	AMPK PD-1/PD-L1 FXR Reactive Oxygen Species (ROS)	Cardiovascular Disease
Kaempferol-7-O-rhamnoside is a PD-1/PD-L1 inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure .

HY-N1778

3,4-Dimethoxycinnamic acid 1 Publications Verification O-Methylferulic acid	Reactive Oxygen Species (ROS) Virus Protease	Infection Cancer
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N4124

Poricoic acid B	NO Synthase TNF Receptor Interleukin Related	Metabolic Disease Inflammation/Immunology
Poricoic acid B is a triterpenoid compound that can be isolated from Poria cocos. Poricoic acid B inhibits intracellular lipid accumulation and reduces the levels of hepatocyte injury markers. Poricoic acid B inhibits the production of NO, TNF-α, IL-1β and IL-6, thereby exerting anti-inflammatory activity. Poricoic acid B can be used in the research of metabolic dysfunction-associated fatty liver disease and inflammatory diseases ^[3].

HY-N1778A

(E)-3,4-Dimethoxycinnamic acid 1 Publications Verification (E)-O-Methylferulic acid	Reactive Oxygen Species (ROS) Virus Protease	Infection Cancer
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N3765

Diosbulbin D	Apoptosis	Metabolic Disease
Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells .

HY-N16513

Muurol-4-ene-3,8-dione	Others	Metabolic Disease
Muurol-4-ene-3,8-dione (Compound 2), a sesquiterpene, is one of the main hepatotoxic components in Eupatorium adenophorum. Muurol-4-ene-3,8-dione has an inhibitory effect on the growth of both the normal human hepatocyte cell L02 and the human hepatocellular carcinoma cell HepG2 with IC₅₀ values of 87.52 and 104.48 μM .

HY-W777084

(E)-3,4-Dimethoxycinnamic acid-13C3 (E)-O-Methylferulic acid-¹³C₃	Reactive Oxygen Species (ROS)	Cancer
(E)-3,4-Dimethoxycinnamic acid- ¹³C₃ ((E)-O-Methylferulic acid- ¹³C₃) is the ¹³C-labeled (E)-3,4-Dimethoxycinnamic acid (HY-N1778A). (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-P3148

Astin B	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species (ROS) JNK Bcl-2 Family Caspase	Metabolic Disease
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

HY-N1778AR

(E)-3,4-Dimethoxycinnamic acid (Standard) (E)-O-Methylferulic acid (Standard)	Reference Standards Reactive Oxygen Species (ROS) Virus Protease	Infection Cancer
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-182053

Antiproliferative agent-76	Apoptosis Drug Derivative NF-κB Wnt	Cancer
Antiproliferative agent-76 (Compound II-2) is an 8-sulfonamidoquinoline derivative and a selective anticancer agent. Antiproliferative agent-76 blocks the NF-κB and WNT signaling pathways. Antiproliferative agent-76 promotes cancer cell Apoptosis. Antiproliferative agent-76 exhibits anticancer activity against colorectal cancer and leukemia .

HY-183716

Mito-TP-2	Drug Derivative	Cancer
Mito-TP-2 is a triptolide (HY-32735) derivative. Mito-TP-2 exhibits concentration-dependent cytotoxicity in cancer cells. Mito-TP-2 is selectively driven and accumulated into the mitochondria of tumor cells by mitochondrial transmembrane potential and exerts specific mitochondrial toxicity. Mito-TP-2 can be used for the research of liver cancer, breast cancer, and non-small cell lung cancer .

HY-181459

PARP1-IN-55	PARP DNA/RNA Synthesis Reactive Oxygen Species (ROS) Apoptosis	Cancer
PARP1-IN-55 is a potent and selective PARP1 inhibitor with an IC₅₀ value of 0.019 μM. PARP1-IN-55 exhibits anti-proliferative selective activity against MCF-7 breast cancer cells (IC₅₀ = 3.6 μM). PARP1-IN-55 inhibits the PARP1-mediated DNA damage repair pathway, induces ROS accumulation, disrupts mitochondrial membrane potential, induced apoptosis and suppresses cancer cell migration, invasion, and colony formation. PARP1-IN-55 can be used for the study of breast cancer .

Cat. No.	Nombre del producto	Target	Research Area

HY-P3148

Astin B	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species (ROS) JNK Bcl-2 Family Caspase	Metabolic Disease
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-N3431

Kaempferol-7-O-rhamnoside	Flavonols Flavonoids other families Classification of Application Fields Phenols Polyphenols Metabolic Disease Chimonanthus nitens Oliv. Plants Disease Research Fields Source Classification Calycanthaceae	AMPK PD-1/PD-L1 FXR Reactive Oxygen Species (ROS)
Kaempferol-7-O-rhamnoside is a PD-1/PD-L1 inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure .

HY-N1778

3,4-Dimethoxycinnamic acid 1 Publications Verification O-Methylferulic acid	Infection Securidaca inappendiculata Hassk. Classification of Application Fields Simple Phenylpropanols Polygalaceae Phenylpropanoids Plants Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Virus Protease
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N4124

Poricoic acid B	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Source Classification Cancer	NO Synthase TNF Receptor Interleukin Related
Poricoic acid B is a triterpenoid compound that can be isolated from Poria cocos. Poricoic acid B inhibits intracellular lipid accumulation and reduces the levels of hepatocyte injury markers. Poricoic acid B inhibits the production of NO, TNF-α, IL-1β and IL-6, thereby exerting anti-inflammatory activity. Poricoic acid B can be used in the research of metabolic dysfunction-associated fatty liver disease and inflammatory diseases ^[3].

HY-N1778A

(E)-3,4-Dimethoxycinnamic acid 1 Publications Verification (E)-O-Methylferulic acid	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Virus Protease
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N16513

Muurol-4-ene-3,8-dione	Structural Classification Pongamia pinnata (L.) Pierre Terpenoids Sesquiterpenes Plants Compositae Source Classification	Others
Muurol-4-ene-3,8-dione (Compound 2), a sesquiterpene, is one of the main hepatotoxic components in Eupatorium adenophorum. Muurol-4-ene-3,8-dione has an inhibitory effect on the growth of both the normal human hepatocyte cell L02 and the human hepatocellular carcinoma cell HepG2 with IC₅₀ values of 87.52 and 104.48 μM .

HY-P3148

Astin B	Alkaloids Other Alkaloids Plants Compositae Erythrina latissima E. Mey. Source Classification	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species (ROS) JNK Bcl-2 Family Caspase
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

HY-N1778AR

(E)-3,4-Dimethoxycinnamic acid (Standard) (E)-O-Methylferulic acid (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Plants Source Classification	Reference Standards Reactive Oxygen Species (ROS) Virus Protease
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

Cat. No.	Nombre del producto	Chemical Structure

HY-W777084

(E)-3,4-Dimethoxycinnamic acid-13C3
(E)-3,4-Dimethoxycinnamic acid- ¹³C₃ ((E)-O-Methylferulic acid- ¹³C₃) is the ¹³C-labeled (E)-3,4-Dimethoxycinnamic acid (HY-N1778A). (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

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L-02 cells

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Isotope-Labeled Compounds

Natural
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