3109617-69-5
Chemical Structure
PARP1-IN-55
- CAS No.: 3109617-69-5
- Formula:C25H35NO5
- Molecular Weight:429.55
InChIKey: GKBPYWOOKNFBCC-YWGGKRRHSA-N
SMILES: O=C1C(CNCC2=CC(OC)=C(OC)C(OC)=C2)[C@@]3([H])C[C@@]4([H])C(CCC[C@]4(C)C[C@@]3([H])O1)=C
Biological Activity: PARP1-IN-55 is a potent and selective PARP1 inhibitor with an IC50 value of 0.019 μM. PARP1-IN-55 exhibits anti-proliferative selective activity against MCF-7 breast cancer cells (IC50 = 3.6 μM). PARP1-IN-55 inhibits the PARP1-mediated DNA damage repair pathway, induces ROS accumulation, disrupts mitochondrial membrane potential, induced apoptosis and suppresses cancer cell migration, invasion, and colony formation. PARP1-IN-55 can be used for the study of breast cancer[1].
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PARP1-IN-55 | PARP1-IN-55 is a potent and selective PARP1 inhibitor with an IC50 value of 0.019 μM. PARP1-IN-55 exhibits anti-proliferative selective activity against MCF-7 breast cancer cells (IC50 = 3.6 μM). PARP1-IN-55 inhibits the PARP1-mediated DNA damage repair pathway, induces ROS accumulation, disrupts mitochondrial membrane potential, induced apoptosis and suppresses cancer cell migration, invasion, and colony formation. PARP1-IN-55 can be used for the study of breast cancer. | |||||||||||||||||||||
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