2489184-70-3
Chemical Structure
Mito-TP-2
- CAS No.: 2489184-70-3
- Formula:C44H48BrO7P
- Molecular Weight:799.73
InChIKey: ARKDMGOZSZHDCD-HYDWVTRASA-M
SMILES: C[C@@]12[C@@]34[C@@]5([C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5)[C@@H]([C@@]7([C@](O7)([H])[C@]3([H])O4)C(C)C)OC(CCCCC[P+](C8=CC=CC=C8)(C9=CC=CC=C9)C%10=CC=CC=C%10)=O.[Br-]
Biological Activity: Mito-TP-2 is a triptolide (HY-32735) derivative. Mito-TP-2 exhibits concentration-dependent cytotoxicity in cancer cells. Mito-TP-2 is selectively driven and accumulated into the mitochondria of tumor cells by mitochondrial transmembrane potential and exerts specific mitochondrial toxicity. Mito-TP-2 can be used for the research of liver cancer, breast cancer, and non-small cell lung cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mito-TP-2 | 96.82% | Mito-TP-2 is a triptolide (HY-32735) derivative. Mito-TP-2 exhibits concentration-dependent cytotoxicity in cancer cells. Mito-TP-2 is selectively driven and accumulated into the mitochondria of tumor cells by mitochondrial transmembrane potential and exerts specific mitochondrial toxicity. Mito-TP-2 can be used for the research of liver cancer, breast cancer, and non-small cell lung cancer. | ||||||||||||||||||||
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- [1]. Fan P, et al. Triptolide derivative and preparation method and application thereof. China, CN111518157A. 2020-08-11.
- [2]. Xing W, et al. Selective Antitumor Effect and Lower Toxicity of Mitochondrion-Targeting Derivatization of Triptolide. J Med Chem. 2024;67(2):1093-1114. [Content Brief]
- [3]. Zhang X, et al. Pro-drug approaches to overcome poor solubility and toxicity of triptolide. Phytochemistry Reviews. 2025 Aug 06;25:1565-1580.
Keywords
