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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
NMDAR Agonist
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "NMDAR Agonist" in MCE Product Catalog:
3
Target:
1
Category:
Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids
Target:
1
1 Cited Publications
Synonyms: Dimethylglycine; DMG; N-Methylsarcosine
1
1 Cited Publications
Cat. No.: HY-W001158
CAS No.: 2491-06-7
Synonyms: Dimethylglycine hydrochloride; DMG hydrochloride; N-Methylsarcosine hydrochloride
Research Areas:
1
1 Cited Publications
Synonyms: Dimethylglycine (Standard); DMG (Standard); N-Methylsarcosine (Standard)
Cat. No.: HY-W001158S
CAS No.: 347840-03-3
Synonyms: Dimethylglycine-d6 hydrochloride; DMG-d6 hydrochloride; N-Methylsarcosine-d6 hydrochloride
Target:
Research Areas:
GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD). GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity .
Cat. No.: HY-100808S
CAS No.: 1414348-52-9
Synonyms: (R)-Serine-d3
Target:
Research Areas:
DQP-997-74 (compound 2i) is a selective negative allosteric modulator of N-methyl-d-aspartate receptor (NMDAR), specifically targeting GluN2C/D (IC50: 0.069 μM and 0.035 μM), with blood-brain barrier penetrability. Where DQP refers to dihydroquinoline-pyrazoline. DQP-997-74 acts synergistically with the agonist glutamate to exhibit time-dependent enhanced potency in inhibiting hypersynchronous activity driven by high-frequency excitatory synaptic transmission. DQP-997-74 reduces the number of epileptogenesis in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 can be used for research on NMDAR-related neurological diseases .
Cat. No.: HY-148250
CAS No.: 3085030-47-0
Target:
Research Areas:
TP-050, a chemical probe, is a potent, orally active and selective NMDAR agonist with an EC50 value of 0.51 μM and 9.6 μM for GluN2A and GluN2D, respecticely. TP-050 can cross the blood-brain barrier (BBB). TP-050 induces hippocampal long-term (LPT) potentiation enhancemen and enhances neuronal signal transmission .
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Homoquinolinic acid is a non endogenous agonist of NMDAR2 receptor .
Cat. No.: HY-100808R
CAS No.: 312-84-5
Synonyms: (R)-Serine (Standard)
Cat. No.: HY-P7060
CAS No.: 117928-93-5
Synonyms: TPPT
Target:
Research Areas:
Cat. No.: HY-W001158S1
CAS No.: 1219795-14-8
Synonyms: Dimethylglycine-d3 hydrochloride; DMG-d3 hydrochloride; N-Methylsarcosine-d3 hydrochloride
Cat. No.: HY-184490
CAS No.: 3118558-91-8
Target:
Research Areas:
BPR1M492 is a brain-penetrant μ-opioid receptor (MOR) agonist an in vitro EC50 of 0.93 nM in the cAMP inhibition assay and 0.004 nM in the FLIPR Ca 2+ assay without a clear signaling bias between cAMP and β-arrestin-2 pathway. BPR1M492 is a cAMP-biased nociceptin-orphanin FQ opioid peptide agonist. BPR1M492 is a weak cAMP-biased δ/κ-opioid receptor agonist. BPR1M492 demonstrates potent in vivo antinociception and can be used for pain research .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
