N,N-Dimethylglycine-d₆ hydrochloride (Synonyms: Dimethylglycine-d6 hydrochloride; DMG-d6 hydrochloride; N-Methylsarcosine-d6 hydrochloride)

Cat. No.: HY-W001158S Pureza: 99.46%: Ficha de datos
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N,N-Dimethylglycine-d₆ (Dimethylglycine-d₆) hydrochloride is the deuterium labeled N,N-Dimethylglycine hydrochloride (HY-W001158). N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects.

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N,N-Dimethylglycine-d<sub>6</sub> hydrochloride

N,N-Dimethylglycine-d₆ hydrochloride Estructura química

No. CAS : 347840-03-3

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Other Forms of N,N-Dimethylglycine-d₆ hydrochloride:

N,N-Dimethylglycine hydrochloride In-stock
N,N-Dimethylglycine In-stock
N,N-Dimethylglycine-d₃ hydrochloride Obtener un presupuesto

Recomendaciones destacadas

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•Related Proteins:

Ver todos los productos específicos de isoformas Endogenous Metabolite:

Ver todas las isoformas

Human Endogenous Metabolite Microbial Metabolite

Ver todos los productos específicos de isoformas iGluR:

Ver todas las isoformas

AMPA Receptor NMDA Receptor Kainate Receptor

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Descripciòn

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

145.62

Fòrmula

C₄H₄D₆ClNO₂

No. CAS

347840-03-3

Unlabeled CAS

2491-06-7

Appearance

Solid

Color

White to off-white

SMILES

OC(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])=O.Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : ≥ 10 mg/mL (68.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.8672 mL	34.3359 mL	68.6719 mL
5 mM	1.3734 mL	6.8672 mL	13.7344 mL
10 mM	0.6867 mL	3.4336 mL	6.8672 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.46%

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Ficha de datos (276 KB) SDS (393 KB)

COA (251 KB) HNMR (639 KB) RP-HPLC (563 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Hsieh CP, et al. N, N-dimethylglycine Protects Behavioral Disturbances and Synaptic Deficits Induced by Repeated Ketamine Exposure in Mice. Neuroscience. 2021 Sep 15;472:128-137. [Content Brief]

[3]. Bai K, et al. Dimethylglycine sodium salt protects against oxidative damage and mitochondrial dysfunction in the small intestines of mice. Int J Mol Med. 2019 May;43(5):2199-2211. [Content Brief]

[4]. Bai K, et al. Assessment of Free Radical Scavenging Activity of Dimethylglycine Sodium Salt and Its Role in Providing Protection against Lipopolysaccharide-Induced Oxidative Stress in Mice. PLoS One. 2016 May 12;11(5):e0155393. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.8672 mL	34.3359 mL	68.6719 mL	171.6797 mL
	5 mM	1.3734 mL	6.8672 mL	13.7344 mL	34.3359 mL
	10 mM	0.6867 mL	3.4336 mL	6.8672 mL	17.1680 mL
	15 mM	0.4578 mL	2.2891 mL	4.5781 mL	11.4453 mL
	20 mM	0.3434 mL	1.7168 mL	3.4336 mL	8.5840 mL
	25 mM	0.2747 mL	1.3734 mL	2.7469 mL	6.8672 mL
	30 mM	0.2289 mL	1.1445 mL	2.2891 mL	5.7227 mL
	40 mM	0.1717 mL	0.8584 mL	1.7168 mL	4.2920 mL
	50 mM	0.1373 mL	0.6867 mL	1.3734 mL	3.4336 mL
	60 mM	0.1145 mL	0.5723 mL	1.1445 mL	2.8613 mL

N,N-Dimethylglycine-d₆ hydrochloride Related Classifications

Neurological Disease Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N-Dimethylglycine-d₆347840-03-3Dimethylglycine-d6DMG-d6N-Methylsarcosine-d6Isotope-Labeled CompoundsEndogenous MetaboliteiGluRAmino Acid DerivativesIonotropic glutamate receptorsInhibitorinhibitorinhibit

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N,N-Dimethylglycine-d6 hydrochloride (Synonyms: Dimethylglycine-d6 hydrochloride; DMG-d6 hydrochloride; N-Methylsarcosine-d6 hydrochloride)

Other Forms of N,N-Dimethylglycine-d6 hydrochloride:

N,N-Dimethylglycine-d6 hydrochloride Related Antibodies

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Endogenous Metabolite:

Ver todos los productos específicos de isoformas iGluR:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

N,N-Dimethylglycine-d6 hydrochloride Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

N,N-Dimethylglycine-d6 hydrochloride Related Classifications