Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
O-GlcNAcylation
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "O-GlcNAcylation" in MCE Product Catalog:
51
51 Cited Publications
Target:
Research Areas:
OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
Cat. No.: HY-N3677
CAS No.: 14351-29-2
Synonyms: ASN90
Target:
Research Areas:
Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase (OGA) enzyme inhibitor with an IC50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and α-synuclein, preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex). Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies (e.g., Alzheimer’s disease and Parkinson’s disease) .
Cat. No.: HY-149552
CAS No.: 67561-97-1
Ac4-5SGlcNAc is an O-GlcNAc transferase (OGT) inhibitor. Ac4-5SGlcNAc converts intracellularly to UDP-5SGlcNAc, which competes with native UDP-GlcNAc (HY-148596) to block OGT catalytic activity, reduces cellular UDP-GlcNAc pools, and limits global protein O-GlcNAcylation. Ac4-5SGlcNAc reduces OGA levels via feedback, alters lectin signal intensities and glycan-related band masses. Ac4-5SGlcNAc can be used for the research of breast cancer .
Cat. No.: HY-P4752
CAS No.: 2022974-40-7
Target:
Research Areas:
Cat. No.: HY-P3795
CAS No.: 361443-81-4
Target:
Research Areas:
Target:
Research Areas:
(Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
Cat. No.: HY-134902
CAS No.: 537039-67-1
Synonyms: UDP-α-6N3-glucose; 6-Azidoglucose-UDP
Research Areas:
UDP-6-azido-6-Deoxy-D-Glc (UDP-α-6N3-glucose; 6-Azidoglucose-UDP) is a UDP-sugar donor . UDP-6-azido-6-Deoxy-D-Glc is used for the selective labeling of 5-hmC in genomic DNA. UDP-6-azido-6-Deoxy-D-Glc enables glyco-diversification modification of saponin intermediates and click chemistry-based derivatization .
Cat. No.: HY-161953
Target:
Research Areas:
O-GlcNAcase-IN-2 (compound 81) is an orally effective, blood-brain barrier-permeable OGA inhibitor (IC50=4.93 nM). O-GlcNAcase-IN-2 can increase the O-GlcNAcylation level of proteins and phosphorylation of tau (p-Ser199, p-Thr205 and p-Ser396) in the OA-damaged SH-SY5Y cell model. O-GlcNAcase-IN-2 can also improve cognitive impairment in APP/PS1 mice and has potential anti-Alzheimer's disease (AD) effects .
Cat. No.: HY-119738R
CAS No.: 1681056-61-0
Target:
Research Areas:
OSMI-1 (Standard) is the analytical standard of OSMI-1 (HY-119738). This product is intended for research and analytical applications. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
Cat. No.: HY-P10572
Target:
Research Areas:
Cat. No.: HY-184176
Target:
Research Areas:
DBCO-PEG3-AP1867 is a bifunctional molecular building block that binds to FKBP12 F36V, and also a SPAAC-compatible reagent suitable for synthesizing O-GlcNAcylation-targeting chimeras (OGTACs) against c-Myc. DBCO-PEG3-AP1867 is applicable to cancer-related research .
Cat. No.: HY-134902A
Synonyms: UDP-α-6N3-glucose disodium; 6-Azidoglucose-UDP disodium
Research Areas:
UDP-6-azido-6-Deoxy-D-Glc disodium (UDP-α-6N3-glucose; 6-Azidoglucose-UDP disodium) is a UDP-sugar donor . UDP-6-azido-6-Deoxy-D-Glc disodium is used for the selective labeling of 5-hmC in genomic DNA. UDP-6-azido-6-Deoxy-D-Glc disodium enables glyco-diversification modification of saponin intermediates and click chemistry-based derivatization .
Cat. No.: HY-W699962
CAS No.: 137766-83-7
Target:
Research Areas:
Ac4GlcNAcF3 is a cell-permeable glycomimetic that can be recognized and utilized by OGT and is resistant to hydrolysis by OGA. GlcNAcF3, the active metabolite of Ac4GlcNAcF3, can be recognized by OGT as a substrate for peptide modification. Ac4GlcNAcF3 upregulates the level of cellular O-GlcNAc modification. Ac4GlcNAcF3 can be used in studies related to glycosylation regulation .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
