137766-83-7
Chemical Structure
Ac4GlcNAcF3
- CAS No.: 137766-83-7
- Formula:C16H20F3NO10
- Molecular Weight:443.33
IUPAC Name: (3R,4R,5S,6R)-6-(acetoxymethyl)-3-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2,4,5-triyl triacetate
InChIKey: XSSGVGGOUZKLAR-GNMOMJPPSA-N
SMILES: O(C(C)=O)[C@@H]1[C@@H](NC(C(F)(F)F)=O)C(OC(C)=O)O[C@H](COC(C)=O)[C@H]1OC(C)=O
Biological Activity: Ac4GlcNAcF3 is a cell-permeable glycomimetic that can be recognized and utilized by OGT and is resistant to hydrolysis by OGA. GlcNAcF3, the active metabolite of Ac4GlcNAcF3, can be recognized by OGT as a substrate for peptide modification. Ac4GlcNAcF3 upregulates the level of cellular O-GlcNAc modification. Ac4GlcNAcF3 can be used in studies related to glycosylation regulation[1].
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Ac4GlcNAcF3 | Ac4GlcNAcF3 is a cell-permeable glycomimetic that can be recognized and utilized by OGT and is resistant to hydrolysis by OGA. GlcNAcF3, the active metabolite of Ac4GlcNAcF3, can be recognized by OGT as a substrate for peptide modification. Ac4GlcNAcF3 upregulates the level of cellular O-GlcNAc modification. Ac4GlcNAcF3 can be used in studies related to glycosylation regulation. | |||||||||||||||||||||
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Keywords
