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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
O6-methylguanine
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "O6-methylguanine" in MCE Product Catalog:
1
1 Cited Publications
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1
Category:
Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics
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1
1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
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1
1 Cited Publications
Cat. No.: HY-P1108A
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Cat. No.: HY-P10272
CAS No.: 1628323-80-7
Synonyms: PTG-300
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Cat. No.: HY-119390
CAS No.: 1869921-96-9
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AA-CW236 is a MGMT (O6-methylguanine DNA methyltransferase) inhibitor. AA-CW236 targets MGMT active site Cys145 for covalent modification .
Cat. No.: HY-P10143
CAS No.: 99828-55-4
Synonyms: Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt
Cat. No.: HY-A0248AS
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Cat. No.: HY-P10563
CAS No.: 2580150-96-3
Synonyms: BHV-1100
Cat. No.: HY-P3066
CAS No.: 77453-01-1
Synonyms: d(CH2)5Tyr(Et)VAVP
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Cat. No.: HY-175299
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Hedgehog IN-11 is an orally active Hedgehog inhibitor. Hedgehog IN-11 downregulates the expression of O6-methylguanine-DNA methyltransferase (MGMT) to impair the Temozolomide (TMZ) (HY-17364) resistance by inhibiting the Hedgehog pathway. Hedgehog IN-11 shows improved inhibition of cell migration and invasion, and induced cell apoptosis in TMZ-resistant GBM cell lines. Hedgehog IN-11 is predicted by computer simulation to have good blood-brain barrier penetration. Hedgehog IN-11 can be used for the study of glioblastoma (GBM) .
Cat. No.: HY-P10828
CAS No.: 1260620-30-1
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Cat. No.: HY-115690
CAS No.: 2269482-26-8
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K-TMZ is a derivative of methyl ketone, which exhibits antitumor efficacy against O 6 -methylguanine DNA methyltransferase (MGMT) deficient cell. K-TMZ can be used for research of glioblastoma .
Cat. No.: HY-13786
CAS No.: 793035-88-8
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O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, O6BTG-C8-αGlu can completely inhibit MGMT in HeLaS3 cells. Even when applied chronically at high doses (up to 20 μM), it does not exhibit cytotoxicity. O6BTG-C8-αGlu is suitable for research on MGMT-related cancer diseases .
Cat. No.: HY-P4756
CAS No.: 282725-67-1
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Cat. No.: HY-P2592
CAS No.: 113714-78-6
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Cat. No.: HY-125628
CAS No.: 179733-11-0
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Cat. No.: HY-P70306
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MGMT; O-6-methylguanine-DNA-Alkyltransferase; O-6-methylguanine-DNA Methyltransferase; O6-methylguanine-DNA Methyltransferase; Methylated-DNA--Protein-Cysteine Methyltransferase; methylguanine-DNA Methyltransferase; 6-O-methylguanine-DNA Methyltransferase
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
