793035-88-8
Chemical Structure
O6BTG-C8-αGlu
- CAS No.: 793035-88-8
- Formula:C24H34BrN5O7S
- Molecular Weight:616.53
IUPAC Name: (2S,3R,4S,5S,6R)-2-((8-(2-amino-6-((4-bromothiophen-2-yl)methoxy)-9H-purin-9-yl)octyl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: WAAZBVOGWRQLMB-GBHDBEGYSA-N
SMILES: BrC1=CSC(COC2=C3C(N(C=N3)CCCCCCCCO[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=NC(N)=N2)=C1
Biological Activity: O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, O6BTG-C8-αGlu can completely inhibit MGMT in HeLaS3 cells. Even when applied chronically at high doses (up to 20 μM), it does not exhibit cytotoxicity. O6BTG-C8-αGlu is suitable for research on MGMT-related cancer diseases[1].
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O6BTG-C8-αGlu | O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, O6BTG-C8-αGlu can completely inhibit MGMT in HeLaS3 cells. Even when applied chronically at high doses (up to 20 μM), it does not exhibit cytotoxicity. O6BTG-C8-αGlu is suitable for research on MGMT-related cancer diseases. | |||||||||||||||||||||
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Keywords
