Oct4

By Targets:	Oct3/4 (9) Apoptosis (2) c-Myc (1) E1/E2/E3 Enzyme (1) Fungal (1) Histone Demethylase (2) Interleukin Related (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Microtubule/Tubulin (1) NF-κB (1) Notch (1) Proteasome (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (2) STAT (2) TET Protein (1)
By Research Areas:	Cancer (9) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Targets Recommended: Oct3/4

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12303

OAC1 1 Publications Verification	Oct3/4 TET Protein	Cancer
OAC1 is a potent *Oct4* activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time .

HY-12884

OAC2 1 Publications Verification	Oct3/4	Others
OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.

HY-18772

O4I2	Oct3/4	Others
O4I2 is a potent *Oct3/4* inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1 .

HY-155528

O4I4	Others	Others
O4I4 (compound 23) is a OCT4-inducing compound with metabolical stability. O4I4 extends lifespan in Caenorhabditis elegans and Drosophila. O4I4 can be used for regenerative medicine and rejuvenation research .

HY-119672

Oct4 inducer-1	Oct3/4	Others
Oct4 inducer-1 (compound OAC-3) is a potent *Oct4* activator. Oct4 inducer-1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. Oct4 inducer-1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time .

HY-116940

Sm4 1 Publications Verification	Oct3/4 Notch STAT	Cancer
Sm4 is a selective and orally active SOX18 inhibitor. Sm4 inhibits SOX18-DNA binding (IC₅₀ = 97.5 μM); Sm4 disrupts the SOX18-RBPJ protein-protein interaction (IC₅₀ = 42.3 μM). Sm4 blocks SOX18 DNA binding, disrupts multiple SOX18 protein-protein interactions with RBPJ, DDX1, DDX17, ILF3, SOX7 and STAT1, modulates SOX18 chromatin binding dynamics. Sm4 exerts anti‑angiogenic and anti‑lymphangiogenic effects, reduces tumor vascular density, triggers vascular defects in zebrafish, prolongs survival in mouse metastatic cancer models. Sm4 can be used for the research of breast cancer .

HY-154951

Oct4 inducer-2	Oct3/4	Others
Oct4 inducer-2 is an *OCT4* inducer, which can maintain the formation of hiPSCs by promoting the expression of endogenous OCT4, which can be used in anti-aging research .

HY-RS10907

POU5F1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
POU5F1 Human Pre-designed siRNA Set A contains three designed siRNAs for POU5F1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

POU5F1 Human Pre-designed siRNA Set A POU5F1 Human Pre-designed siRNA Set A

HY-N15201

Betavulgarin	STAT	Cancer
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44 ⁺/CD24 ⁻ subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling .

HY-RS10908

Pou5f1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pou5f1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pou5f1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pou5f1 Mouse Pre-designed siRNA Set A Pou5f1 Mouse Pre-designed siRNA Set A

HY-165606

SB-T-1214	Oct3/4 c-Myc Apoptosis	Cancer
SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133 ⁺/CD44 ⁺ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers .

HY-129108

9-cis-UAB30 (9Z)-UAB-30	Oct3/4 Microtubule/Tubulin E1/E2/E3 Enzyme Proteasome	Neurological Disease Cancer
9-cis-UAB30 is a rexinoid agonist. 9-cis-UAB30 significantly decreases the proliferation, viability, and motility of both patient-derived xenografts (PDXs). 9-cis-UAB30 induced cell-cycle arrest as demonstrated by the significant increase in the percentage of cells in G1 and a decrease in the percentage of cells in S phase by downregulating SKP2 and/or 20S proteasome activity, which leads to increased p27kip1 protein stability. 9-cis-UAB30 downregulates the abundance of stem cell marker mRNAs (Oct4, Nanog, Sox2, nestin) and upregulates the abundance of differentiation marker mRNAs (β3-tubulin, NSE, HOXC9, GAP43). 9-cis-UAB30 has no adverse effects on the central nervous system and cardiovascular system at the tested dose. 9-cis-UAB30 can be used for the study of neuroblastoma, cutaneous T-cell lymphomas, and breast cancer .

HY-119666

Rooperol	Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Oct3/4	Inflammation/Immunology Cancer
Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as *Oct4, Nanog, and Sox2*, ultimately exerting its anticancer effects ^[4].

HY-179339

LSD1-IN-46	Histone Demethylase	Cancer
LSD1-IN-46 is a potent and orally active Lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 0.082 μM. LSD1-IN-46 interrupts the β-catenin-mediated transcriptional program, thereby suppressing the stemness of gastric cancer cells. LSD1-IN-46 exhibits strong anti-tumor activity. LSD1-IN-46 can be used for the research of gastric cancer .

HY-W777329

(4E)-4-Octenedioic acid-13C2 (E)-Oct-4-ene-1,8-dioic acid-¹³C₂	Isotope-Labeled Compounds	Others
(4E)-4-Octenedioic acid- ¹³C₂ ((E)-Oct-4-ene-1,8-dioic acid- ¹³C₂) is the ¹³C-labeled (4E)-4-Octenedioic acid (HY-W151203).

HY-N19791

6-Methoxymellein	NF-κB Fungal Interleukin Related	Infection Cancer
6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44 ⁺/CD24 ⁻ breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot .

HY-15313B

CBB1007 hydrochloride	Histone Demethylase	Metabolic Disease Cancer
CBB1007 hydrochloride is a reversible and selective LSD1 inhibitor with an IC₅₀ of 5.27 µM for human LSD1. CBB1007 hydrochloride significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me. CBB1007 hydrochloride shows selectivity for LSD1 over LSD2 or JARID1A, and induces differentiation-related genes in pluripotent cells. CBB1007 hydrochloride is studied in non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma .

Cat. No.	Product Name

HY-L039

Reprogramming Compound Library	3,086 compounds
Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells. MCE Reprogramming Compound Library contains a unique collection of 3,086 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Reprogramming Compound Library

3,086 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 3,086 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Cat. No.	Product Name

HY-K6019

Stem Cell Cryopreservation Medium
90%) and stable expression of pluripotency markers such as OCT4 and NANOG, providing consistent and reliable cell sources for subsequent expansion and differentiation. This product is suitable for long-term, stable storage of PSCs and downstream applications.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15201

Betavulgarin	Structural Classification Flavonoids Beta vulgaris Linn. Plants Isoflavones Chenopodiaceae Source Classification	STAT
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44 ⁺/CD24 ⁻ subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling .

HY-N19791

6-Methoxymellein	Structural Classification Monophenols Coumarins Phenols Phenylpropanoids Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants Source Classification	NF-κB Fungal Interleukin Related
6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44 ⁺/CD24 ⁻ breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot .

Cat. No.	Product Name	Chemical Structure

HY-W777329

(4E)-4-Octenedioic acid-13C2
(4E)-4-Octenedioic acid- ¹³C₂ ((E)-Oct-4-ene-1,8-dioic acid- ¹³C₂) is the ¹³C-labeled (4E)-4-Octenedioic acid (HY-W151203).

Host:	Mouse (6) Rabbit (2)
Reactivity:	Human (7) Mouse (3)
Application:	IHC-P (4) ICC/IF (6) IP (2) WB (6) ChIP (1) FC (4) ELISA (5)
Isotype:	IgG,Kappa (1) IgG (2) IgG1 (5)
Conjugation:	Non-conjugated (8)
Clonality:	Polyclonal (1) Monoclonal (3) Monoclonal Antibody (2) Recombinant (1)
Modification:	Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84463

	Oct-4 Antibody (YA4160) Oct3; Oct4; OTF3; OTF4; OTF-3; Oct-3; Oct-4	IHC-P, FC, ELISA	Human
	Oct-4 Antibody (YA4160) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Oct-4.

HY-P84463A

	Oct-4 Antibody (YA4160)(PBS only) Oct3; Oct4; OTF3; OTF4; OTF-3; Oct-3; Oct-4	IHC-P, FC, ELISA	Human
	Oct-4 Antibody (YA4160) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Oct-4.

HY-P84462

	Oct-4 Antibody (YA4159) Oct3; Oct4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; MGC22487; POU5F1	WB, ICC/IF, FC, ELISA	Human
	Oct-4 Antibody (YA4159) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Oct-4.

HY-P84462A

	Oct-4 Antibody (YA4159)(PBS only) Oct3; Oct4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; MGC22487; POU5F1	WB, ICC/IF, FC, ELISA	Human
	Oct-4 Antibody (YA4159) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Oct-4.

HY-P80440

	Oct-4 Antibody (YA837) MGC22487; Oct 3; Oct 4; Oct-3; Oct-4; Oct3; Oct4; Octamer binding protein 3; Octamer binding protein 4; Octamer binding transcription factor 3; Octamer-binding protein 3; Octamer-binding protein 4; Octamer-binding transcription factor 3; OTF 3; OTF 4; OTF	WB, ICC/IF	Human, Mouse
	Oct-4 Antibody (YA837) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Oct-4.

HY-P87771

	Oct-4 Antibody (YA7456)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse
	Oct-4 Antibody (YA7456) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to 45934.

HY-P85304

	Oct-3/4 Antibody (YA4996) POU5F1; Oct3; Oct4; OTF3; POU domain; class 5, transcription factor 1; Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3	WB, ICC/IF
	Oct-3/4 Antibody (YA4996) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Oct-3/4.

HY-P80770

	Oct-4 Antibody MGC22487; Oct 3; Oct 4; Oct-3; Oct-4; Oct3; Oct4; Octamer binding protein 3; Octamer binding protein 4; Octamer binding transcription factor 3; Octamer-binding protein 3; Octamer-binding protein 4; Octamer-binding transcription factor 3; OTF 3; OTF 4; OTF	WB, IHC-P, ICC/IF, IP, ChIP	Human, Mouse
	Oct-4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Oct-4.

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Cat. No.	Product Name		Classification

HY-RS10907

POU5F1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
POU5F1 Human Pre-designed siRNA Set A contains three designed siRNAs for POU5F1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10908

Pou5f1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pou5f1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pou5f1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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