365542-77-4

Sm4 Chemical Structure
365542-77-4

Chemical Structure

Sm4

  • CAS No.: 365542-77-4
  • Formula:C19H16O3
  • Molecular Weight:292.33

IUPAC Name: 2-hydroxy-6-(2-(naphthalen-2-yl)ethyl)benzoic acid

InChIKey: GGVFBUYNEPBFQT-UHFFFAOYSA-N

SMILES: O=C(C1=C(C=CC=C1O)CCC2=CC=C3C=CC=CC3=C2)O

Biological Activity: Sm4 is a selective and orally active SOX18 inhibitor. Sm4 inhibits SOX18-DNA binding (IC50 = 97.5 μM); Sm4 disrupts the SOX18-RBPJ protein-protein interaction (IC50 = 42.3 μM). Sm4 blocks SOX18 DNA binding, disrupts multiple SOX18 protein-protein interactions with RBPJ, DDX1, DDX17, ILF3, SOX7 and STAT1, modulates SOX18 chromatin binding dynamics. Sm4 exerts anti‑angiogenic and anti‑lymphangiogenic effects, reduces tumor vascular density, triggers vascular defects in zebrafish, prolongs survival in mouse metastatic cancer models. Sm4 can be used for the research of breast cancer[1][2].

Cat. No. Product Name Purity Description Pricing
HY-116940 		Sm4 99.01% Sm4 is a selective and orally active SOX18 inhibitor. Sm4 inhibits SOX18-DNA binding (IC50 = 97.5 μM); Sm4 disrupts the SOX18-RBPJ protein-protein interaction (IC50 = 42.3 μM). Sm4 blocks SOX18 DNA binding, disrupts multiple SOX18 protein-protein interactions with RBPJ, DDX1, DDX17, ILF3, SOX7 and STAT1, modulates SOX18 chromatin binding dynamics. Sm4 exerts anti‑angiogenic and anti‑lymphangiogenic effects, reduces tumor vascular density, triggers vascular defects in zebrafish, prolongs survival in mouse metastatic cancer models. Sm4 can be used for the research of breast cancer.
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