1 Result for "

P53R3

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "P53R3" in MCE Product Catalog:

Cat. No.: HY-122578
CAS No.: 922150-12-7
Purity:  99.93%
Target:  

MDM-2/p53

Research Areas:  

Cancer

P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53 R175H, p53 R248W and p53 R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53 M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research .
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