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Penicillium sp.

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (4) Apoptosis (1) Bacterial (4) Biochemical Assay Reagents (2) Cathepsin (1) Cholinesterase (ChE) (1) Drug Intermediate (1) Endogenous Metabolite (4) Fungal (6) Glycosidase (1) HSV (1) Neurokinin Receptor (1) Opioid Receptor (2) Parasite (2) Phosphatase (1)
By Research Areas:	Cancer (4) Infection (10) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1759A

N-CBZ-Phe-Arg-AMC hydrochloride Z-FR-AMC hydrochloride	Cathepsin	Others
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) hydrochloride is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .

HY-120551

Fructigenine A	Others	Others
Fructigenine A (compound 4) is a active product that can be isolated from marine-derived Penicillium sp. .

HY-158721

Penicinoline Marinamide	Endogenous Metabolite Parasite	Infection Cancer
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

HY-N12761

Penpaxilloids A	Phosphatase Glycosidase	Metabolic Disease Inflammation/Immunology
Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity .

HY-P2840A

*Dextranase, Penicillium* sp.**	Biochemical Assay Reagents	Metabolic Disease
Dextranase, Penicillium sp. (EC 3.2.1.11) hydrolyzes-(1,6)-glucosidic linkages in dextran. Dextranase, Penicillium sp. (EC 3.2.1.11) has been used for hydrolyzing dextran at sugar mills in order to improve efficiency of sugar production.

HY-N12184

Peniciside	Others	Others
Peniciside is a triterpenoid glycoside derived from the fungus Penicillium sp.169 .

HY-E70104A

*α-Rhamnosidase, Penicillium* sp.**	Biochemical Assay Reagents	Metabolic Disease
α-Rhamnosidase, Penicillium sp. (EC 3.2.1.40) catalyzes the cleavage of the bond between terminal L (+)-rhamnose and the aglycone of rhamnose-containing glycosides.

HY-123474

PF-1163B	Fungal Antibiotic	Infection
PF-1163B is an antifungal antibiotic .

HY-N12266

12-Hydroxyalbrassitriol	Others	Others
12-Hydroxyalbrassitriol is a drimane sesquiterpenoid that can be isolated from Penicillium sp .

HY-W741556

Dehydrogriseofulvin	Antibiotic Fungal	Infection
Dehydrogriseofulvin can be isolated from Penicillium sp. Dehydrogriseofulvin inhibits Colletotrichum musae with MIC > 1 µg/scrip.

HY-N13086

Peniviridiol A	Others	Others
Peniviridiol A (compound4) is a viridin derivative that can be isolated from rhizosphere fungus Penicillium sp. SMU0102 .

HY-124301

Penicolinate A	Bacterial	Infection
Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities .

HY-N8498

GKK1032B	Apoptosis	Cancer
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .

HY-N16412

Citreomontanin Citreomontanine	Drug Intermediate	Others
Citreomontanin (Citreomontanine) (Compound 3), an α‑Pyrone polyketide, is an intermediate of Citreoviripyrone A. Citreomontanin can be isolated from the mycelium of endophytic Penicillium sp. in Catharanthus roseus. Citreoviripyrone A has a moderate inhibitory activity on HCT116 cells growth .

HY-P4107

Bilaid C	Opioid Receptor	Neurological Disease
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (K_i=210 nM, hMOPr) .

HY-118463

Benzomalvin A (-)-Benzomalvin A	Neurokinin Receptor	Neurological Disease
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively .

HY-P3044

Bilaid A1e	Opioid Receptor	Neurological Disease
Bilaid A1e (Compound 1e) is a tetrapeptide agonist of the µ-opioid receptor (K_i = 750 nM). Bilaid A1e can be isolated from an Australian estuarine isolate of Penicillium sp. Bilaid A1e can be used for pain research .

HY-123457

PF-1163A	Fungal	Infection
PF-1163A is an antifungal agent that inhibits Ergosterol (HY-N0181) synthesis (IC₅₀ = 12 ng/mL), which is found in a fermentation broth of Penicillium sp. PF-1163A also inhibits C-4 sterol methyl oxidase with an MIC value of 12.5 µg/mL .

HY-130757

Remisporine B	Endogenous Metabolite	Inflammation/Immunology
Remisporine B is a polyketide, that can be isolated from Penicillium sp. ZJ-SY2. Remisporine B exhibits immunosuppressive efficacy, that inhibits concanavalin A (HY-P2149)-induced T-cell proliferation and LPS (HY-D1056)- induced B-cell proliferations of mouse splenic lymphocytes with IC₅₀ of 30.1 µg/mL and 32.4 µg/mL .

HY-N10177

Peniterphenyl A	HSV	Infection
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits HSV-1/2 virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .

HY-135535

Sclerotioramine	Endogenous Metabolite Bacterial Fungal	Infection
Sclerotioramine (Compound 1), a red pigment, is an antioxidant compound. Sclerotioramine can be isolated from the endolichenic fungus Penicillium sp.-strain 1322P. Sclerotioramine has potent antibacterial activity with MICs of 3.125, 3.125 and 6.25 μg/mL for Bacillus subtilis, Bacillus megaterium and Shigella dysentery, respectively. Sclerotioramine also has significant antifungal activity against Pestalotiopsis theae, Cochliobolus miyabeanus and Exserohilum turcicum .

HY-N12165

1,3,5,6-Tetrahydroxy-8-methylxanthone	Others	Others
1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .

HY-117092

BE-31405	Antibiotic Fungal	Infection
BE-31405 is an antifungal antibiotic. BE-31405 can be isolated from the culture broth of the fungal strains such as Penicillium minioluteum F31405, Talaromyces siamensis FKA-61, and Phomopsis sp. FKA-62. BE-31405 exhibits potent growth inhibitory activity against pathogenic fungal strains including Candida albicans, Candida glabrata, and Cryptococcus neoformans. BE-31405 shows no cytotoxicity against mammalian cells .

HY-N12230

Penicolinate B	Bacterial Parasite Fungal	Infection Cancer
Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC₅₀: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC₅₀: 25.0 μg/mL), and activity against Candida albicans (IC₅₀: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors .

HY-184043

Pinazaphilone A	Others	Others
Pinazaphilone A is a type of polyketide compound derived from the mangrove endophytic fungus Penicillium sp .

HY-N16447

Territrem C	Cholinesterase (ChE)	Others
Territrem C is an acetylcholinesterase (AchE) inhibitor with an IC₅₀ value of 0.23 μM. Territrem C, which belongs to α-pyrone meroterpenoids, can be isolated and produced from the fungus Penicillium sp. SK5GW1L .

HY-N19220

Radiclonic acid	Bacterial Endogenous Metabolite Antibiotic	Infection Cancer
Radiclonic acid acts as an antibacterial agent, anticancer agent, and root growth promoter. Radiclonic acid is isolable from fungi of the genus Penicillium. Radiclonic acid exhibits antibacterial activity against MRSA with a MIC of 3.13 μg/mL. Radiclonic acid shows anticancer activity against esophageal cancer, bladder cancer, and liver cancer. Radiclonic acid promotes root growth in Chinese cabbage seedlings. Radiclonic acid is inactive against pancreatic cancer and cervical cancer. Radiclonic acid can be used in research related to Staphylococcus aureus infection, bladder cancer, esophageal cancer, and liver cancer .

N-CBZ-Phe-Arg-AMC hydrochloride Z-FR-AMC hydrochloride	Biochemical Assay Reagents
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) hydrochloride is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .

Cat. No.	Product Name	Target	Research Area

HY-P5941

Bilaid C1	Peptides	Others
Bilaid C1 is a tetrapeptide isolated from Penicillium sp .

HY-P4107

Bilaid C	Opioid Receptor	Neurological Disease
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (K_i=210 nM, hMOPr) .

HY-P3044

Bilaid A1e	Opioid Receptor	Neurological Disease
Bilaid A1e (Compound 1e) is a tetrapeptide agonist of the µ-opioid receptor (K_i = 750 nM). Bilaid A1e can be isolated from an Australian estuarine isolate of Penicillium sp. Bilaid A1e can be used for pain research .

Fructigenine A	Natural Products Microorganisms Source Classification	Others
Fructigenine A (compound 4) is a active product that can be isolated from marine-derived Penicillium sp. .

Penicinoline Marinamide	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Endogenous Metabolite Parasite
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

Penpaxilloids A	Terpenoids Marine natural products Diterpenoids Marine microorganism Source Classification	Phosphatase Glycosidase
Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity .

Peniciside	Triterpenes Microorganisms Terpenoids Source Classification	Others
Peniciside is a triterpenoid glycoside derived from the fungus Penicillium sp.169 .

PF-1163B	Microorganisms Ketones, Aldehydes, Acids Source Classification	Fungal Antibiotic
PF-1163B is an antifungal antibiotic .

12-Hydroxyalbrassitriol	Microorganisms Terpenoids Sesquiterpenes Source Classification	Others
12-Hydroxyalbrassitriol is a drimane sesquiterpenoid that can be isolated from Penicillium sp .

Peniviridiol A	Microorganisms Terpenoids Sesquiterpenes Source Classification	Others
Peniviridiol A (compound4) is a viridin derivative that can be isolated from rhizosphere fungus Penicillium sp. SMU0102 .

Penicolinate A	Infection Alkaloids Microorganisms Classification of Application Fields Pyridine Alkaloids Disease Research Fields Source Classification	Bacterial
Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities .

GKK1032B	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Cancer Source Classification	Apoptosis
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .

Citreomontanin Citreomontanine	Microorganisms Ketones, Aldehydes, Acids Source Classification	Drug Intermediate
Citreomontanin (Citreomontanine) (Compound 3), an α‑Pyrone polyketide, is an intermediate of Citreoviripyrone A. Citreomontanin can be isolated from the mycelium of endophytic Penicillium sp. in Catharanthus roseus. Citreoviripyrone A has a moderate inhibitory activity on HCT116 cells growth .

Benzomalvin A (-)-Benzomalvin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Quinoline Alkaloids Endogenous metabolite Source Classification	Neurokinin Receptor
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively .

Remisporine B	Microorganisms Xanthones Phenols Source Classification	Endogenous Metabolite
Remisporine B is a polyketide, that can be isolated from Penicillium sp. ZJ-SY2. Remisporine B exhibits immunosuppressive efficacy, that inhibits concanavalin A (HY-P2149)-induced T-cell proliferation and LPS (HY-D1056)- induced B-cell proliferations of mouse splenic lymphocytes with IC₅₀ of 30.1 µg/mL and 32.4 µg/mL .

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Penicillium sp.

Inhibitors & Agonists

Biochemical Assay Reagents

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NaturalProducts

Natural
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