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Ph+

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229

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134653
    5-Ph-IAA
    50+ Cited Publications

    		 Epigenetic Reader Domain Cancer
    5-Ph-IAA is a derivative of IAA. 5-Ph-IAA, a ligand, establishes the auxin-inducible degron 2 (AID2) system together with an OsTIR1 (F74G) mutant. AID2 induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, causing tumor suppression .
    5-Ph-IAA
  • HY-10403
    PH-797804
    5+ Cited Publications

    		 p38 MAPK Autophagy Inflammation/Immunology Cancer
    PH-797804 is a ATP-competitive, selective p38α/p38β inhibitor (IC50=26 nM and Ki=5.8 nM for p38α; Ki=40 nM for p38β) and does not inhibit JNK2.
    PH-797804
  • HY-B1610N
    Sodium Citrate Buffer, 0.1M, pH 4.0
    5+ Cited Publications

    		 Biochemical Assay Reagents Others
    Sodium Citrate Buffer, 0.1M, pH 4.0 is an acidic, aqueous buffer solution. Sodium Citrate Buffer, 0.1M, pH 4.0 resists pH fluctuations, chelates metal ions, and regulates the redox potential of the system. Sodium Citrate Buffer, 0.1M, pH 4.0 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .
    Sodium Citrate Buffer, 0.1M, pH 4.0
  • HY-Y1968A
    Sterile 10 mM Histidine, pH 5.5 buffer

    Sterile 10 mM His-HCl, pH 5.5 buffer

    		 Biochemical Assay Reagents Others
    Sterile 10 mM Histidine, pH 5.5 buffer is a sterile solution using 10 mM histidine as the solute with its pH adjusted to 5.5, possessing both buffering capacity and biocompatibility. Sterile 10 mM Histidine, pH 5.5 buffer is widely applied in laboratory research, pharmaceutical production, cosmetics and other fields .
    Sterile 10 mM Histidine, pH 5.5 buffer
  • HY-D1563
    pH Receptor Probe
    1 Publications Verification

    		 Fluorescent Dye Others
    pH Receptor Probe is a pH-sensitive cyanine derivative and a environmental sensitive fluorophore. pH Receptor Probe has a pH-sensitive maximal absorption at 644 nm and emission at 664 nm. pH Receptor Probe has been used as a pH sensor of lysosomal compartments .
    pH Receptor Probe
  • HY-130283
    Methyltetrazine-Ph-NHS ester

    		PROTAC Linkers Cancer
    Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-Ph-NHS ester
  • HY-148530
    YX-2-107

    		PROTACs CDK Cancer
    YX-2-107 is a PROTAC (IC50= 4.4 nM) that selectively degrades CDK6. YX-2-107 effectively inhibits RB phosphorylation and FOXM1 expression in vitro and inhibits the development of Ph + ALL in rats. YX-2-107 can be used in the study of Ph chromosome-positive (Ph +) acute lymphoblastic leukemia (ALL) .
    YX-2-107
  • HY-112798
    PH-002

    		Apolipoprotein Neurological Disease
    PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.
    PH-002
  • HY-160113
    Sodium phosphate buffer 0.02 M, pH 6.9

    		Biochemical Assay Reagents Others
    Sodium phosphate buffer 0.02 M, pH 6.9 is a commonly used aqueous biological buffer that maintains a stable pH value. Sodium phosphate buffer 0.02 M, pH 6.9 is often used in enzyme activity assays, such as α-amylase assays. Sodium phosphate buffer 0.02 M, pH 6.9 is prepared by mixing disodium hydrogen phosphate (Na2HPO4) (HY-B2243) and sodium dihydrogen phosphate (NaH2PO4) (HY-Y0308) to a total concentration of 0.02 M .
    Sodium phosphate buffer 0.02 M, pH 6.9
  • HY-10499
    PH-064
    2 Publications Verification

    BIM-46187

    		 Serotonin Transporter Akt Neurological Disease Inflammation/Immunology Cancer
    PH-064 (BIM-46187) is an orally active inhibitor of the heterotrimeric G-protein complex. PH-064 inhibits SERT activity and attenuates shear stress-induced Akt phosphorylation. PH-064 has potent anti-hyperalgesia activity. PH-064 inhibits G protein-coupled receptor-dependent tumorigenesis. PH-064 can be used in the study of pain (e.g., inflammatory pain, neuropathic pain), GPCR-dependent tumors, and inflammatory lung injury .
    PH-064
  • HY-126524
    N3-Ph-NHS ester

    		ADC Linker Cancer
    N3-Ph-NHS ester (compound 133) is an organic synthesis intermediate and ADC linker used for the synthesis of antibody-drug conjugate (ADC) molecules .
    N3-Ph-NHS ester
  • HY-141894
    5-Ph-IAA-AM
    2 Publications Verification

    		 Histone Acetyltransferase Metabolic Disease
    5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation .
    5-Ph-IAA-AM
  • HY-130107
    Ald-Ph-NHS ester

    		ADC Linker Cancer
    Ald-Ph-NHS ester is a nonclaevable linker for antibody-agent-conjugation (ADC).
    Ald-Ph-NHS ester
  • HY-130551
    Tetrazine-Ph-PEG5-NHS ester

    		PROTAC Linkers Cancer
    Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-PEG5-NHS ester
  • HY-179669C
    1M Tris-HCl Buffer, pH 7.6

    		Biochemical Assay Reagents Others
    1M Tris-HCl Buffer, pH 7.6 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.
    1M Tris-HCl Buffer, pH 7.6
  • HY-179669
    1M Tris-HCl Buffer, pH 6.8

    		Biochemical Assay Reagents Others
    1M Tris-HCl Buffer, pH 6.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.
    1M Tris-HCl Buffer, pH 6.8
  • HY-179669I
    1.5M Tris-HCl Buffer, pH 8.8

    		Biochemical Assay Reagents Others
    1M Tris-HCl Buffer, pH 8.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.
    1.5M Tris-HCl Buffer, pH 8.8
  • HY-160114A
    Potassium phosphate buffer (0.1 M, pH 7.5)

    		Biochemical Assay Reagents Others
    Potassium phosphate buffer (0.1 M, pH 7.5) is a potassium phosphate buffer with a concentration of 0.1 M and a pH of 7.5.
    Potassium phosphate buffer (0.1 M, pH 7.5)
  • HY-DY1071
    pH Receptor Probe (solution)

    		Fluorescent Dye Others
    pH Receptor Probe (solution) is a pH-sensitive cyanine derivative and a environmental sensitive fluorophore. pH Receptor Probe has a pH-sensitive maximal absorption at 644 nm and emission at 664 nm. pH Receptor Probe has been used as a pH sensor of lysosomal compartments .
    Solvent and concentration: DMSO: 10 mM
    pH Receptor Probe (solution)
  • HY-149669
    PH14

    		PI3K HDAC Apoptosis Cancer
    PH14 is a dual PI3K/HDAC inhibitor with IC50 values of 20.3 nM and 24.5 nM for PI3Kα and HDAC3, respectively. PH14 has antiproliferative activity and also induces apoptosis in Jeko-1 cells. PH14 can be used in cancer research, such as lymphoma .
    PH14
  • HY-160113E
    Sodium phosphate buffer 0.1M, pH 8.0

    		Biochemical Assay Reagents Others
    Sodium phosphate buffer 0.1M, pH 8.0 is an aqueous sodium phosphate buffer with a concentration of 0.1M and a pH value of 8.0. Sodium phosphate buffer 0.1M, pH 8.0 can be used for the preparation of hydrated micellar membranes, the construction of pH-sensitive nanocarriers, and the maintenance of stable environmental conditions for pH-cleavable PEG-Hz-PE micelles. Sodium phosphate buffer 0.1M, pH 8.0 can also serve as a universal solvent, reaction medium and eluent, and is widely applied in experimental processes such as antibody thiolation, nanoparticle purification and cross-linking reactions .
    Sodium phosphate buffer 0.1M, pH 8.0
  • HY-Y0682I
    0.5M Ethylenediaminetetraacetic acid Solution, pH 8.0

    0.5M EDTA Solution, pH 8.0

    		 Biochemical Assay Reagents Others
    0.5M Ethylenediaminetetraacetic acid Solution, pH 8.0 (0.5M EDTA Solution, pH 8.0) is a commonly used molecular biology reagent used for chelating magnesium ions, etc. This product is prepared using EDTA-Na2 and the pH value is adjusted to 8.0 with NaOH.
    0.5M Ethylenediaminetetraacetic acid Solution, pH 8.0
  • HY-B0246S3
    Carbamazepine-(Ph)d8

    CBZ-(Ph)d8; NSC 169864-(Ph)d8

    		 Isotope-Labeled Compounds Neurological Disease Cancer
    Carbamazepine-(Ph)d8 (CBZ-(Ph)d8; NSC 169864-(Ph)d8) is the deuterium labeled Carbamazepine-(Ph) (HY-B0246) .
    Carbamazepine-(Ph)d8
  • HY-124480
    Tetrazine-Ph-acid

    		PROTAC Linkers Cancer
    Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-acid
  • HY-179669A
    1M Tris-HCl Buffer, pH 7.0

    		Biochemical Assay Reagents Others
    1M Tris-HCl Buffer, pH 7.0 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.
    1M Tris-HCl Buffer, pH 7.0
  • HY-179669E
    1M Tris-HCl Buffer, pH 8.0

    		Biochemical Assay Reagents Others
    1M Tris-HCl Buffer, pH 8.0 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.
    1M Tris-HCl Buffer, pH 8.0
  • HY-126908
    Tetrazine-Ph-NHS ester

    		PROTAC Linkers Cancer
    Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-NHS ester
  • HY-153395
    PH-HG-005-5

    		Drug-Linker Conjugates for ADC Cancer
    PH-HG-005-5 (compound 16c) is a derivative of SN-38 (HY-13704) and can be used as Drug-Linker Conjugates for ADC. PH-HG-005-5 can conjugate to targeting peptides for ADCs synthesis .
    PH-HG-005-5
  • HY-151797
    Ph-HTBA

    		CaMK Neurological Disease
    Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders .
    Ph-HTBA
  • HY-141808
    AZD-CO-Ph-PEG4-Ph-CO-AZD

    		Beta-lactamase Cancer
    AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis .
    AZD-CO-Ph-PEG4-Ph-CO-AZD
  • HY-179669H
    1M Tris-HCl Buffer, pH 8.8

    		Biochemical Assay Reagents Others
    1M Tris-HCl Buffer, pH 8.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values indicated on the product are the pH values of the Tris-HCl buffer solution at 25°C.
    1M Tris-HCl Buffer, pH 8.8
  • HY-179669J
    1.5M Tris-HCl Buffer, pH 6.8

    		Biochemical Assay Reagents Others
    1M Tris-HCl Buffer, pH 6.8 is a buffer solution commonly used in various biochemical and molecular biological applications to maintain a stable pH environment. The pH value of Tris-HCl changes with temperature; generally, the pH decreases by 0.03 units for every degree Celsius increase in temperature. The pH values ??indicated on the product are the pH values ??of the Tris-HCl buffer solution at 25°C.
    1.5M Tris-HCl Buffer, pH 6.8
  • HY-160114
    Potassium phosphate buffer (0.1 M, pH 6.9)

    		Biochemical Assay Reagents Others
    Potassium phosphate buffer (0.1 M, pH 6.9) is a buffer.
    Potassium phosphate buffer (0.1 M, pH 6.9)
  • HY-179667
    PH calibration buffer, pH 4.01

    		Biochemical Assay Reagents Others
    PH calibration buffer (pH 4.01) is a pH calibration buffer with a pH value of 4.01.
    PH calibration buffer, pH 4.01
  • HY-130928
    Tetrazine-Ph-OPSS

    		ADC Linker Cancer
    Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-OPSS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-OPSS
  • HY-116497
    PH11

    		FAK Cancer
    PH11 is a novel focal adhesion kinase (FAK) inhibitor that rapidly induces apoptosis in TRAIL-resistant PANC-1 cells when combined with TRAIL, but has no effect on normal human fibroblasts. The study found that PH11 downregulates c-FLIP through inhibition of FAK and phosphatidylinositol-3-kinase (PI3K)/AKT pathways, thereby restoring the TRAIL apoptotic pathway, suggesting that this combination therapy may provide an attractive therapeutic strategy for the safe and effective treatment of pancreatic cancer. PH11 selectively inhibits c-FLIP expression by modulating upstream signaling pathways and may represent an innovative therapeutic strategy. Although further work is needed to fully elucidate the mechanism of PH11-induced TRAIL sensitization, we believe that our results will provide a new approach to target c-FLIP without the risk of interfering with caspase-8 processing, which could potentially lead to TRAIL resistance. This study also suggests a role for the FAK/AKT signaling pathway in regulating c-FLIP expression in TRAIL-induced apoptosis, and this understanding will provide important clues to control the resistance mechanism to optimize the potential of TRAIL-based pancreatic cancer treatment.
    PH11
  • HY-W576870
    Hydrouracil-3-Ph-COOH

    		Ligands for E3 Ligase Cancer
    Hydrouracil-3-Ph-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Hydrouracil-3-Ph-COOH can be linked to a target protein ligand via a linker to form a PROTAC.
    Hydrouracil-3-Ph-COOH
  • HY-W293394
    Boc-cyclohexane-piperazine-Ac-Ph

    		PROTAC Linkers Cancer
    Boc-cyclohexane-piperazine-Ac-Ph is a PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-cyclohexane-piperazine-Ac-Ph
  • HY-W761300
    1-(4-Pip-Ph)-DHP-dione

    		Ligands for E3 Ligase Others
    1-(4-Pip-Ph)-DHP-dione is an E3 ligase ligand. 1-(4-Pip-Ph)-DHP-dione can be used for synthesis of PROTAC HPK1 Degrader-2 (HY-162544) .
    1-(4-Pip-Ph)-DHP-dione
  • HY-180447
    Tz-Ph-PEG4-NH-DOTA

    		Radionuclide-Drug Conjugates (RDCs) Cancer
    Tz-Ph-PEG4-NH-DOTA (Compound 10) is a 1,2,4,5-tetrazine (Tz) derivative. Tz-Ph-PEG4-NH-DOTA can be used in PET imaging and tumor research .
    Tz-Ph-PEG4-NH-DOTA
  • HY-W190821
    Ph-PEG9-NH2

    		PROTAC Linkers Cancer
    Ph-PEG9-NH2 is a PROTAC linker that can be used in the synthesis of PROTACs.
    Ph-PEG9-NH2
  • HY-W592697
    Dihydrouracil-Ph-piperazine-Boc

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Dihydrouracil-Ph-piperazine-Boc is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
    Dihydrouracil-Ph-piperazine-Boc
  • HY-133044
    Boc-Pip-alkyne-Ph-COOH

    		PROTAC Linkers Cancer
    Boc-Pip-alkyne-Ph-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-Pip-alkyne-Ph-COOH can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 effectively induces degradation of androgen receptor (AR) protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM . Boc-Pip-alkyne-Ph-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-Pip-alkyne-Ph-COOH
  • HY-140626
    Ald-Ph-PEG4-Boc

    		PROTAC Linkers Cancer
    Ald-Ph-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Ald-Ph-PEG4-Boc
  • HY-140627
    Ald-Ph-PEG6-Boc

    		PROTAC Linkers Cancer
    Ald-Ph-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Ald-Ph-PEG6-Boc
  • HY-176362S
    4-F-Benzenesulfonate-pyrrole(2-F-Ph)-methylamine-d3

    		Isotope-Labeled Compounds Others
    4-F-Benzenesulfonate-pyrrole(2-F-Ph)-methylamine-d3 is the deuterium labeled 4-F-Benzenesulfonate-pyrrole(2-F-Ph)-methylamine.
    4-F-Benzenesulfonate-pyrrole(2-F-Ph)-methylamine-d3
  • HY-144121
    Ph-Ph+

    		Bacterial Fungal Apoptosis Infection Cancer
    Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities .
    Ph-Ph+
  • HY-133465
    Tetrazine-Ph-PEG4-Ph-aldehyde

    		PROTAC Linkers Cancer
    Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-PEG4-Ph-aldehyde
  • HY-133463
    Tetrazine-Ph-PEG5-Ph-tetrazine

    		PROTAC Linkers Cancer
    Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-Ph-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-PEG5-Ph-tetrazine
  • HY-120804
    PH-46A

    		Amyloid-β Inflammation/Immunology
    PH-46A is an indane dimer with anti-inflammatory activity. PH-46A can reduced histological damage and serum amyloid A (SAA) levels in colitis mice .
    PH-46A

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