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Phytolacca americana

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By Targets:	Apoptosis (1) ATM/ATR (1) Biochemical Assay Reagents (1) CDK (1) Checkpoint Kinase (Chk) (1) E1/E2/E3 Enzyme (1) MDM-2/p53 (1) Mitosis (2) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (2)

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Biochemical Assay Reagents

Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-NP187

Phytolacca americana Lectin PWM	Biochemical Assay Reagents Mitosis
Phytolacca americana Lectin (PWM) is a lectin that specific for N-acetylglucosamine-containing saccharides. Phytolacca americana Lectin stimulates peripheral lymphocytes to undergo mitosis by binding to their cell surfaces. Phytolacca americana Lectin can be used as a probe to specifically bind to biological molecules. Phytolacca americana Lectin is a biomaterial or organic compound that can be used in life science research .

HY-N18168

Esculentoside L	Others	Cancer
Esculentoside L is a triterpene saponin present in the roots of Phytolacca americana. Esculentoside L increases the intracellular accumulation of calcein in multidrug-resistant human ovarian cancer cells. Esculentoside L exerts no significant cytotoxic activity against non-cancerous cells and hepatocytes. Esculentoside L can be used in studies related to multidrug-resistant human ovarian cancer .

HY-N18301

Americanin A	ATM/ATR Checkpoint Kinase (Chk) MDM-2/p53 E1/E2/E3 Enzyme CDK Mitosis Reactive Oxygen Species (ROS) Apoptosis	Cancer
Americanin A is a Neolignan. Americanin A can be isolated from the seeds of Phytolacca americana. Americanin A activates ATM and ATR, initiating the subsequent signal transduction cascades that include Chk1, Chk2, and tumor suppressor p53. Americanin A targets selectively Skp2 for degradation and thereby stabilizes p27. Americanin A suppresses the activity of Cyclin B1 and its partner cdc2 to prevent entry into Mitosis. Americanin A induces Apoptosis by producing excessive ROS. Americanin A has anti-cancer activity against colorectal cancer .

Cat. No.	Product Name	Type

HY-NP187

Phytolacca americana Lectin PWM	Biochemical Assay Reagents
Phytolacca americana Lectin (PWM) is a lectin that specific for N-acetylglucosamine-containing saccharides. Phytolacca americana Lectin stimulates peripheral lymphocytes to undergo mitosis by binding to their cell surfaces. Phytolacca americana Lectin can be used as a probe to specifically bind to biological molecules. Phytolacca americana Lectin is a biomaterial or organic compound that can be used in life science research .

Phytolacca americana Lectin

PWM

Biochemical Assay Reagents

Phytolacca americana Lectin (PWM) is a lectin that specific for N-acetylglucosamine-containing saccharides. Phytolacca americana Lectin stimulates peripheral lymphocytes to undergo mitosis by binding to their cell surfaces. Phytolacca americana Lectin can be used as a probe to specifically bind to biological molecules. Phytolacca americana Lectin is a biomaterial or organic compound that can be used in life science research .

Esculentoside L	Structural Classification Terpenoids Plants Pentacyclic Triterpenoids Phytolacca americana L. Phytolaccaceae Source Classification	Others
Esculentoside L is a triterpene saponin present in the roots of Phytolacca americana. Esculentoside L increases the intracellular accumulation of calcein in multidrug-resistant human ovarian cancer cells. Esculentoside L exerts no significant cytotoxic activity against non-cancerous cells and hepatocytes. Esculentoside L can be used in studies related to multidrug-resistant human ovarian cancer .

Americanin A	Structural Classification Monophenols Phenols Plants Phytolacca americana L. Phytolaccaceae Source Classification	ATM/ATR Checkpoint Kinase (Chk) MDM-2/p53 E1/E2/E3 Enzyme CDK Mitosis Reactive Oxygen Species (ROS) Apoptosis
Americanin A is a Neolignan. Americanin A can be isolated from the seeds of Phytolacca americana. Americanin A activates ATM and ATR, initiating the subsequent signal transduction cascades that include Chk1, Chk2, and tumor suppressor p53. Americanin A targets selectively Skp2 for degradation and thereby stabilizes p27. Americanin A suppresses the activity of Cyclin B1 and its partner cdc2 to prevent entry into Mitosis. Americanin A induces Apoptosis by producing excessive ROS. Americanin A has anti-cancer activity against colorectal cancer .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Phytolacca americana

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
Products